Implementation of type 1 diabetes genetic risk screening in children in diverse communities: the Virginia PrIMeD project von Guertin, Kristin A, Repaske, David R, Taylor, Julia F, Williams, Eli S, Onengut-Gumuscu, Suna, Chen, Wei-Min, Boggs, Sarah R, Yu, Liping, Allen, Luke, Botteon, Lacey, Daniel, Louis, Keating, Katherine G, Labergerie, Mika K, Lienhart, Tyler S, Gonzalez-Mejia, Jorge A, Starnowski, Matt J, Rich, Stephen S

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Identification and Validation of an Anthracycline/ Cyclophosphamide-Based Chemotherapy Response Assay in Breast Cancer von MULLIGAN, Jude M, HILL, Laura A, QUINN, Jennifer E, LINDOR, Noralane M, MULLAN, Paul B, JAMES, Colin R, WALKER, Steven M, KERR, Peter, JAMES, Jacqueline, DAVISON, Timothy S, PROUTSKI, Vitali, SALTO-TELLEZ, Manuel, DEHARO, Steve, JOHNSTON, Patrick G, COUCH, Fergus J, HARKIN, D. Paul, KENNEDY, Richard D, IRWIN, Gareth, BOYLE, David, KEATING, Katherine E, RAJI, Olaide Y, MCDYER, Fionnuala A, O'BRIEN, Eamonn, BYLESJO, Max

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Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling von Foster, Joseph M, Oumie, Assa, Togneri, Fiona S, Vasques, Fabiana Ramos, Hau, Debra, Taylor, Morag, Tinkler-Hundal, Emma, Southward, Katie, Medlow, Paul, McGreeghan-Crosby, Keith, Halfpenny, Iris, McMullan, Dominic J, Quirke, Phil, Keating, Katherine E, Griffiths, Mike, Spink, Karen G, Brew, Fiona

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A NGS-Targeted Autism/ID Panel Reveals Compound Heterozygous GNB5 Variants in a Novel Patient von Malerba, Natascia, Towner, Shelley, Keating, Katherine, Squeo, Gabriella Maria, Wilson, William, Merla, Giuseppe

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ATM associates with and phosphorylates p53: mapping the region of interaction von Khanna, Kum Kum, Keating, Katherine E, Kozlov, Sergei, Scott, Shaun, Gatei, Magtouf, Hobson, Karen, Taya, Yoichi, Gabrielli, Brian, Chan, Doug, Lees-Miller, Susan P, Lavin, Martin F

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Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue von Huang, Shuguang, Reitze, Nicholas J, Ewing, Amy L, McCreary, Suzanne, Uihlein, Arlette H, Brower, Stacey L, Wang, Dakun, Wang, Tianhua, Gabrin, Michael J, Keating, Katherine E, Mulligan, Jude, Wilson, Claire, Davison, Timothy, McKenzie, Stuart, Tsao, Ming-Sound, Shepherd, Frances A, Plamadeala, Victoria

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UNINTENDED CONSEQUENCES OF FETAL PERSONHOOD STATUTES: EXAMPLES FROM TAX, TRUSTS, AND ESTATES von Crawford, Bridget J, Borders, Alexis C, Keating, Katherine

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Use of molecular NGS vs single gene testing differs by clinical setting and physician’s specialty in mNSCLC management von Keating, Katherine Elizabeth, Hewitt, Rachael Victoria, Ramos Cirillo, Priscila Daniele Daniele, Smart, Dave, Abrunhosa Amaral, Inês, Sandberg, Tessa Paulien, Slifko, Bethany Michelle, Alarcon Ruiz, Jose Luis, Keeling, Derry Mae, Kennedy, Chloe Laura, Moore, Wendy, Clark, Jordan, Munksted, Susanne, McLeod, Howard L.

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Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein von KEATING, Katherine E, GUEVEN, Nuri, WATTERS, Dianne, RODEMANN, H. Peter, LAVIN, Martin F

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Pseudodeficiency of alpha-iduronidase is a common finding identified from newborn screening in the state of Illinois von Keating, Katherine G., Whiteaker, Lauren, Corkery, Jill, Charrow, Joel, Burton, Barbara

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Epidermal Growth Factor Sensitizes Cells to Ionizing Radiation by Down-regulating Protein Mutated in Ataxia-Telangiectasia von Gueven, Nuri, Keating, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H., Lavin, Martin F.

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ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro von Kozlov, Sergei, Gueven, Nuri, Keating, Katherine, Ramsay, Jonathan, Lavin, Martin F.

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Abstract MIP-055: IDENTIFICATION OF A MOLECULAR SUBTYPE OF HIGH GRADE SEROUS OVARIAN CANCER REPRESENTING MAPK PATHWAY ACTIVATION AND PLATINUM RESISTANCE von El-Helali, Aya, McCabe, Nuala, Gourley, Charlie, McCavigan, Andrena, Michie, Caroline O., Price, Bethanie, McGivern, Niamh, Churchman, Michael, El-Helai, Aya, O'Brien, Eamonn J., Hill, Laura, Davison, Timothy S, Williams, Alistair, McCluggage, W Glenn, Keating, Katherine E, Harkin, Denis P, Kennedy, Richard

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Abstract 626: Cross-site reproducibility and orthogonal validation of copy number and somatic mutation calls of OncoScan® FFPE Assay Kit in solid tumors von Foster, Joseph M., Oumie, Assa, Togneri, Fiona S., Taylor, Morag, Alyas, Sofia, Wojtowicz, Paula, Wood, Henry, Tinkler-Hundal, Emma, Southward, Katie, McMullan, Dominic, Quirke, Phil, Keating, Katherine E., Griffiths, Mike, Spink, Karen G., Brew, Fiona, Fung, Eric, Schmidt, Jeanette

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Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling von Snijders Blok, Lot, Madsen, Erik, Juusola, Jane, Gilissen, Christian, Baralle, Diana, Reijnders, Margot R.F, Venselaar, Hanka, Helsmoorte, Céline, Cho, Megan T, Hoischen, Alexander, Vissers, Lisenka E.L.M, Koemans, Tom S, Wissink-Lindhout, Willemijn, Eichler, Evan E, Romano, Corrado, Van Esch, Hilde, Stumpel, Connie, Vreeburg, Maaike, Smeets, Eric, Obemdorff, Karin, van Bon, Bregje W.M, Shaw, Marie, Gecz, Jozef, Haan, Eric, Bienek, Melanie, Jensen, Corinna, Loeys, Bart L, Van Dijck, Anke, Innes, A. Micheil, Racher, Hilary, Vermeer, Sascha, Di Donato, Nataliya, Rump, Andreas, Tatton-Brown, Katrina, Parker, Michael J, Henderson, Alex, Lynch, Sally A, Fryer, Alan, Ross, Alison, Vasudevan, Pradeep, Kini, Usha, Newbury-Ecob, Ruth, Chandler, Kate, Male, Alison, the DDD Study, Dijkstra, Sybe, Schieving, Jolanda, Giltay, Jacques, van Gassen, Koen L.I, Schuurs-Hoeijmakers, Janneke, Tan, Perciliz L, Pediaditakis, Igor, Haas, Stefan A, Retterer, Kyle, Reed, Patrick, Monaghan, Kristin G, Haverfield, Eden, Natowicz, Marvin, Myers, Angela, Kruer, Michael C, Stein, Quinn, Strauss, Kevin A, Brigatti, Karlla W, Keating, Katherine, Burton, Barbara K, Kim, Katherine H, Charrow, Joel, Norman, Jennifer, Foster-Barber, Audrey, Kline, Antonie D, Kimball, Amy, Zackai, Elaine, Harr, Margaret, Fox, Joyce, McLaughlin, Julie, Lindstrom, Kristin, Haude, Katrina M, van Roozendaal, Kees, Brunner, Han, Chung, Wendy K, Kooy, R. Frank, Pfundt, Rolph, Kalscheuer, Vera, Mehta, Sarju G, Katsanis, Nicholas, Kleefstra, Tjitske

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Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling von Snijders Blok, Lot, Madsen, Erik, Juusola, Jane, Gilissen, Christian, Baralle, Diana, Reijnders, Margot R F, Venselaar, Hanka, Helsmoortel, Céline, Cho, Megan T, Hoischen, Alexander, Vissers, Lisenka E L M, Koemans, Tom S, Wissink-Lindhout, Willemijn, Eichler, Evan E, Romano, Corrado, Van Esch, Hilde, Stumpel, Connie, Vreeburg, Maaike, Smeets, Eric, Oberndorff, Karin, Van Bon, Bregje W M, Shaw, Marie, Gecz, Jozef, Haan, Eric, Bienek, Melanie, Jensen, Corinna, Loeys, Bart L, Van Dijck, Anke, Innes, A. Micheil, Racher, Hilary, Vermeer, Sascha, Di Donato, Nataliya, Rump, Andreas, Tatton-Brown, Katrina, Parker, Michael J, Henderson, Alex, Lynch, Sally A, Fryer, Alan, Ross, Alison, Vasudevan, Pradeep, Kini, Usha, Newbury-Ecob, Ruth, Chandler, Kate, Male, Alison, Dijkstra, Sybe, Schieving, Jolanda, Giltay, Jacques, Van gassen, Koen L I, Schuurs-Hoeijmakers, Janneke, Tan, Perciliz L, Pediaditakis, Igor, Haas, Stefan A, Retterer, Kyle, Reed, Patrick, Monaghan, Kristin G, Haverfield, Eden, Natowicz, Marvin, Myers, Angela, Kruer, Michael C, Stein, Quinn, Strauss, Kevin A, Brigatti, Karlla W, Keating, Katherine, Burton, Barbara K, Kim, Katherine H, Charrow, Joel, Norman, Jennifer, Foster-Barber, Audrey, Kline, Antonie D, Kimball, Amy, Zackai, Elaine, Harr, Margaret, Fox, Joyce, McLaughlin, Julie, Lindstrom, Kristin, Haude, Katrina M, Van Roozendaal, Kees, Brunner, Han, Chung, Wendy K, Kooy, R. Frank, Pfundt, Rolph, Kalscheuer, Vera, Mehta, Sarju G, Katsanis, Nicholas, Kleefstra, Tjitske

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Performance of a prognostic genomic signature for early-stage NSCLC in matched fresh frozen and RNA-stabilized tissue von Huang, Shuguang, Ewing, Amy L, Reitze, Nicholas J, Uihlein, Arlette H, Wang, Dakun, Gabrin, Michael J, Keating, Katherine E., Mulligan, Jude, Wilson, Claire, Davison, Timothy, McKenzie, Stuart, Tsao, Ming-Sound, Shepherd, Frances A., Brower, Stacey L

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Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab von Gourley, Charlie, McCavigan, Andrena, Perren, Timothy, Paul, James, Michie, Caroline Ogilvie, Churchman, Michael, Williams, Alistair, McCluggage, W. Glenn, Parmar, Mahesh, Kaplan, Richard S., Hill, Laura A., Halfpenny, Iris A, O'Brien, Eamonn J., Raji, Olaide, Deharo, Steve, Davison, Timothy, Johnston, Patrick, Keating, Katherine E., Harkin, D. Paul, Kennedy, Richard D.

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ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation von Kozlov, Sergei, Gueven, Nuri, Keating, Katherine, Ramsay, Jonathan, Lavin, Martin F

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Abstract 4820: Identification of a metagene representing SRC activation which is predictive of response to Dasatinib von McCabe, Nuala, Wikstrom, Katarina, Delaney, Thomas, Walker, Steven M., Goffard, Nicolas, Deharo, Steve, Hill, Laura, McDyer, Fionnuala, Keating, Katherine, Harkin, Dennis P., Gourley, Charlie, Kennedy, Richard D.

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