Development and Application of a Recyclable High-Load Magnetic Co/C Hybrid ROMP-Derived Benzenesulfonyl Chloride Reagent and Utility of Corresponding Analogues von Faisal, Saqib, Zang, Qin, Maity, Pradip K, Brandhofer, Agnes, Kearney, Patrick C, Reiser, Oliver, Grass, Robert N, Stoianova, Diana, Hanson, Paul R

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Discovery of XL413, a potent and selective CDC7 inhibitor von Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.

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Rothemund and Adler-Longo reactions revisited: synthesis of tetraphenylporphyrins under equilibrium conditions von Lindsey, Jonathan S, Schreiman, Irwin C, Hsu, Henry C, Kearney, Patrick C, Marguerettaz, Anne M

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The design, synthesis, and biological evaluation of PIM kinase inhibitors von Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei

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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors von Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen

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Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position von Kearney, Patrick C, Zhang, Haiyun, Zhong, Wenge, Dougherty, Dennis A, Lester, Henry A

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Solid-Phase Synthesis of 2-Aminothiazoles von Kearney, Patrick C, Fernandez, Monica, Flygare, John A

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A Selective Receptor for Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt Bridges That Are Highly Exposed to Water von Ngola, Sarah M, Kearney, Patrick C, Mecozzi, Sandro, Russell, Keith, Dougherty, Dennis A

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Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena von Kearney, Patrick C, Mizoue, Laura S, Kumpf, Robert A, Forman, Jonathan E, McCurdy, Alison, Dougherty, Dennis A

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Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells von Nowak, Mark W., Kearney, Patrick C., Sampson, Jeffrey R., Saks, Margaret E., Labarca, Cesar G., Silverman, Scott K., Zhong, Wenge, Thorson, Jon, Abelson, John N., Davidson, Norman, Schultz, Peter G., Dougherty, Dennis A., Lester, Henry A.

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Development and Application of a Recyclable High Load Magnetic Co/C Hybrid ROMP-derived Benzene Sulfonyl Chloride Reagent and Utility of Corresponding Analogs von Faisal, Saqib, Zang, Qin, Maity, Pradip K., Brandhofer, Agnes, Kearney, Patrick C., Reiser, Oliver, Grass, Robert N., Stoianova, Diana, Hanson, Paul R.

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Abstract 4938: DP-9024, an investigational small molecule modulator of the integrated stress response kinase GCN2, synergizes with asparaginase therapy in leukemic tumors von Al-Ani, Gada, Elliott, Kristin M., Groer, Qi, Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 1639: DP-9149, an investigational small molecule modulator of the Integrated Stress Response kinase GCN2, pre-clinically causes solid tumor growth inhibition as a single a... von Al-Ani, Gada, Groer, Qi, Elliott, Kristin M., Rudeen, Aaron J., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 1640: DP-9024, an investigational small molecule modulator of the Integrated Stress Response kinase PERK, causes B-cell cancer growth inhibition as single agent and in com... von Al-Ani, Gada, Groer, Qi, Rudeen, Aaron J., Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Abstract 1613: Dimerization-induced activation of the integrated stress response kinase PERK by an investigational small molecule modulator, DP-9024 von Al-Ani, Gada, Rudeen, Aaron J., Groer, Qi, Elliott, Kristin M., Kearney, Patrick C., Zwicker, Jeffery D., Ahn, Yu Mi, Bulfer, Stacie L., Heiniger, Cale L., Hood, Molly M., Javid, Salim, Large, Joshua W., Petty, Max D., Stoltz, Kristen L., Bourdonnec, Bertrand Le, Smith, Bryan D., Flynn, Daniel L.

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Erratum to “Discovery of XL413, a potent and selective CDC7 inhibitor” [Bioorg. Med. Chem. Lett. 22 (2012) 3727–3731] von Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.

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Molecular recognition: multipoint contacts with new sizes and shapes von Lindsey, Jonathan S, Kearney, Patrick C, Duff, Robert J, Tjivikua, P. Tjama, Rebek, Julius

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An Engineered Tetrahymena tRNAGln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression von Saks, M E, Sampson, J R, Nowak, M W, Kearney, P C, Du, F, Abelson, J N, Lester, H A, Dougherty, D A

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Solid-phase synthesis of disubstituted guanidines von Kearney, Patrick C., Fernandez, Monica, Flygare, John A.

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Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists von Kearney, P C, Nowak, M W, Zhong, W, Silverman, S K, Lester, H A, Dougherty, D A

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