Advances and considerations in AD tau-targeted immunotherapy von Bittar, Alice, Bhatt, Nemil, Kayed, Rakez

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RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction von Montalbano, Mauro, McAllen, Salome, Puangmalai, Nicha, Sengupta, Urmi, Bhatt, Nemil, Johnson, Omar D., Kharas, Michael G., Kayed, Rakez

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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis von Nguyen, Phuong H, Ramamoorthy, Ayyalusamy, Sahoo, Bikash R, Zheng, Jie, Faller, Peter, Straub, John E, Dominguez, Laura, Shea, Joan-Emma, Dokholyan, Nikolay V, De Simone, Alfonso, Ma, Buyong, Nussinov, Ruth, Najafi, Saeed, Ngo, Son Tung, Loquet, Antoine, Chiricotto, Mara, Ganguly, Pritam, McCarty, James, Li, Mai Suan, Hall, Carol, Wang, Yiming, Miller, Yifat, Melchionna, Simone, Habenstein, Birgit, Timr, Stepan, Chen, Jiaxing, Hnath, Brianna, Strodel, Birgit, Kayed, Rakez, Lesné, Sylvain, Wei, Guanghong, Sterpone, Fabio, Doig, Andrew J, Derreumaux, Philippe

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Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective von Derry, Paul J., Hegde, Muralidhar L., Jackson, George R., Kayed, Rakez, Tour, James M., Tsai, Ah-Lim, Kent, Thomas A.

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Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons von Ruan, Zhi, Pathak, Dhruba, Venkatesan Kalavai, Srinidhi, Yoshii-Kitahara, Asuka, Muraoka, Satoshi, Bhatt, Nemil, Takamatsu-Yukawa, Kayo, Hu, Jianqiao, Wang, Yuzhi, Hersh, Samuel, Ericsson, Maria, Gorantla, Santhi, Gendelman, Howard E, Kayed, Rakez, Ikezu, Seiko, Luebke, Jennifer I, Ikezu, Tsuneya

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Aβ/tau oligomer interplay at human synapses supports shifting therapeutic targets for Alzheimer’s disease von Marcatti, Michela, Fracassi, Anna, Montalbano, Mauro, Natarajan, Chandramouli, Krishnan, Balaji, Kayed, Rakez, Taglialatela, Giulio

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice von Lasagna-Reeves, Cristian A, Castillo-Carranza, Diana L, Sengupta, Urmi, Clos, Audra L, Jackson, George R, Kayed, Rakez

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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases von Abud, Edsel M., Ramirez, Ricardo N., Martinez, Eric S., Healy, Luke M., Nguyen, Cecilia H.H., Newman, Sean A., Yeromin, Andriy V., Scarfone, Vanessa M., Marsh, Samuel E., Fimbres, Cristhian, Caraway, Chad A., Fote, Gianna M., Madany, Abdullah M., Agrawal, Anshu, Kayed, Rakez, Gylys, Karen H., Cahalan, Michael D., Cummings, Brian J., Antel, Jack P., Mortazavi, Ali, Carson, Monica J., Poon, Wayne W., Blurton-Jones, Mathew

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Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein von Sengupta, Urmi, Puangmalai, Nicha, Bhatt, Nemil, Garcia, Stephanie, Zhao, Yingxin, Kayed, Rakez

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease von Lasagna‐Reeves, Cristian A., Castillo‐Carranza, Diana L., Sengupta, Urmi, Sarmiento, Jose, Troncoso, Juan, Jackson, George R., Kayed, Rakez

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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons von Wu, Jessica W., Herman, Mathieu, Liu, Li, Simoes, Sabrina, Acker, Christopher M., Figueroa, Helen, Steinberg, Joshua I., Margittai, Martin, Kayed, Rakez, Zurzolo, Chiara, Di Paolo, Gilbert, Duff, Karen E.

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Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies von Puangmalai, Nicha, Bhatt, Nemil, Montalbano, Mauro, Sengupta, Urmi, Gaikwad, Sagar, Ventura, Frank, McAllen, Salome, Ellsworth, Anna, Garcia, Stephanie, Kayed, Rakez

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TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia von Montalbano, Mauro, McAllen, Salome, Cascio, Filippa Lo, Sengupta, Urmi, Garcia, Stephanie, Bhatt, Nemil, Ellsworth, Anna, Heidelman, Eric A., Johnson, Omar D., Doskocil, Samantha, Kayed, Rakez

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Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding von Moreira, Guilherme G., Cantrelle, François-Xavier, Quezada, Andrea, Carvalho, Filipa S., Cristóvão, Joana S., Sengupta, Urmi, Puangmalai, Nicha, Carapeto, Ana P., Rodrigues, Mário S., Cardoso, Isabel, Fritz, Güenter, Herrera, Federico, Kayed, Rakez, Landrieu, Isabelle, Gomes, Cláudio M.

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Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives von Lo Cascio, Filippa, Puangmalai, Nicha, Ellsworth, Anna, Bucchieri, Fabio, Pace, Andrea, Palumbo Piccionello, Antonio, Kayed, Rakez

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Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease von Troncone, Luca, PhD, Luciani, Marco, MD, Coggins, Matthew, MD, Wilker, Elissa H., ScD, Ho, Cheng-Ying, MD, PhD, Codispoti, Kari Elise, MD, Frosch, Matthew P., MD, PhD, Kayed, Rakez, PhD, del Monte, Federica, MD, PhD

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P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease von Farmer, Kathleen M, Ghag, Gaurav, Puangmalai, Nicha, Montalbano, Mauro, Bhatt, Nemil, Kayed, Rakez

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Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies von Bittar, Alice, Sengupta, Urmi, Kayed, Rakez

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Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases von Sengupta, Urmi, Kayed, Rakez

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Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies von Comerota, Michele M., Tumurbaatar, Batbayar, Krishnan, Balaji, Kayed, Rakez, Taglialatela, Giulio

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