Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients von Coppieters, Ken T, Dotta, Francesco, Amirian, Natalie, Campbell, Peter D, Kay, Thomas W H, Atkinson, Mark A, Roep, Bart O, von Herrath, Matthias G

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Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes von Pathiraja, Vimukthi, Kuehlich, Janine P, Campbell, Peter D, Krishnamurthy, Balasubramanian, Loudovaris, Thomas, Coates, P Toby H, Brodnicki, Thomas C, O'Connell, Philip J, Kedzierska, Katherine, Rodda, Christine, Bergman, Philip, Hill, Erin, Purcell, Anthony W, Dudek, Nadine L, Thomas, Helen E, Kay, Thomas W H, Mannering, Stuart I

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Development of a standardized MRI protocol for pancreas assessment in humans von Virostko, John, Craddock, Richard C., Williams, Jonathan M., Triolo, Taylor M., Hilmes, Melissa A., Kang, Hakmook, Du, Liping, Wright, Jordan J., Kinney, Mara, Maki, Jeffrey H., Medved, Milica, Waibel, Michaela, Kay, Thomas W. H., Thomas, Helen E., Greeley, Siri Atma W., Steck, Andrea K., Moore, Daniel J., Powers, Alvin C.

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Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes von Waibel, Michaela, Wentworth, John M, So, Michelle, Couper, Jennifer J, Cameron, Fergus J, MacIsaac, Richard J, Atlas, Gabby, Gorelik, Alexandra, Litwak, Sara, Sanz-Villanueva, Laura, Trivedi, Prerak, Ahmed, Simi, Martin, Francis J, Doyle, Madeleine E, Harbison, Jessica E, Hall, Candice, Krishnamurthy, Balasubramanian, Colman, Peter G, Harrison, Leonard C, Thomas, Helen E, Kay, Thomas W H

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T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities von Wiede, Florian, Brodnicki, Thomas C, Goh, Pei Kee, Leong, Yew A, Jones, Gareth W, Yu, Di, Baxter, Alan G, Jones, Simon A, Kay, Thomas W H, Tiganis, Tony

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Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine von Pöysti, Sakari, Silojärvi, Satu, Brodnicki, Thomas C, Catterall, Tara, Liu, Xin, Mackin, Leanne, Luster, Andrew D, Kay, Thomas W H, Christen, Urs, Thomas, Helen E, Hänninen, Arno

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Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation von Bhattacharyya, Sandip, Zhao, Yuxing, Kay, Thomas W.H, Muglia, Louis J

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Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice von HONG SHENG QUAH, MIRANDA-HERNANDEZ, Socorro, GRAHAM, Kate L, KHOO, Aimee, HARDING, Ashley, FYNCH, Stacey, ELKERBOUT, Lorraine, BRODNICKI, Thomas C, BAXTER, Alan G, KAY, Thomas W. H, THOMAS, Helen E

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Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans von Simeonovic, Charmaine J, Popp, Sarah K, Starrs, Lora M, Brown, Debra J, Ziolkowski, Andrew F, Ludwig, Barbara, Bornstein, Stefan R, Wilson, J Dennis, Pugliese, Alberto, Kay, Thomas W H, Thomas, Helen E, Loudovaris, Thomas, Choong, Fui Jiun, Freeman, Craig, Parish, Christopher R

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Understanding and preventing type 1 diabetes through the unique working model of TrialNet von Battaglia, Manuela, Anderson, Mark S., Buckner, Jane H., Geyer, Susan M., Gottlieb, Peter A., Kay, Thomas W. H., Lernmark, Åke, Muller, Sarah, Pugliese, Alberto, Roep, Bart O., Greenbaum, Carla J., Peakman, Mark

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Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes von Virostko, John, Wright, Jordan J, Williams, Jonathan M, Hilmes, Melissa A, Triolo, Taylor M, Broncucia, Hali, Du, Liping, Kang, Hakmook, Nallaparaju, Shreya, Valencia, Leah Galvez, Reyes, Demetra, Hammel, Brenna, Russell, William E, Philipson, Louis H, Waibel, Michaela, Kay, Thomas W H, Thomas, Helen E, Greeley, Siri Atma W, Steck, Andrea K, Powers, Alvin C, Moore, Daniel J

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Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice von Akazawa, Satoru, Mackin, Leanne, Jhala, Gaurang, Fynch, Stacey, Catterall, Tara, Selck, Claudia, Graham, Kate L., Krishnamurthy, Balasubramanian, Pappas, Evan G., Kwong, Chun-Ting J., Sutherland, Andrew P. R., Kay, Thomas W. H., Brodnicki, Thomas C., Thomas, Helen E.

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Monitoring immunomodulation strategies in type 1 diabetes von Krishnamurthy, Balasubramanian, Lacorcia, Matthew, Kay, Thomas W H, Thomas, Helen E, Mannering, Stuart I

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Proinsulin C-peptide is an autoantigen in people with type 1 diabetes von So, Michelle, Elso, Colleen M., Tresoldi, Eleonora, Pakusch, Miha, Pathiraja, Vimukthi, Wentworth, John M., Harrison, Leonard C., Krishnamurthy, Balasubramanian, Thomas, Helen E., Rodda, Christine, Cameron, Fergus J., McMahon, Jacinta, Kay, Thomas W. H., Mannering, Stuart I.

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Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP von Krishnamurthy, Balasubramanian, Dudek, Nadine L, McKenzie, Mark D, Purcell, Anthony W, Brooks, Andrew G, Gellert, Shane, Colman, Peter G, Harrison, Leonard C, Lew, Andrew M, Thomas, Helen E, Kay, Thomas W H

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Do all patients require ureteroscopy prior to nephroureterectomy? von Bultitude, Matthew, Nair, Rajesh, Thomas, Kay

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Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity von Galic, Sandra, Sachithanandan, Nirupa, Kay, Thomas W, Steinberg, Gregory R

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Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax von MCKENZIE, Mark D, JAMIESON, Emma, JANSEN, Elisa S, SCOTT, Clare L, HUANG, David C. S, BOUILLET, Philippe, ALLISON, Janette, KAY, Thomas W. H, STRASSER, Andreas, THOMAS, Helen E

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IL-17F induces inflammation, dysfunction and cell death in mouse islets von Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E., Sutherland, Andrew P. R.

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Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes von Selck, Claudia, Jhala, Gaurang, De George, David J, Kwong, Chun-Ting J, Christensen, Marie K, Pappas, Evan G, Liu, Xin, Ge, Tingting, Trivedi, Prerak, Kallies, Axel, Thomas, Helen E, Kay, Thomas W H, Krishnamurthy, Balasubramanian

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