Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double‐Blind, Placebo‐Controlled Single‐Ascen... von Tabuchi, Hiroko, Katsurabara, Toshinori, Mori, Masahiko, Aoyama, Muneo, Obara, Takashi, Yasuda, Nobuyuki, Kawano, Tetsu, Imai, Toshio, Ieiri, Ichiro, Kumagai, Yuji

Volltext

Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX3CL1/CX3CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis von Luong, Vu H., Utsunomiya, Akira, Chino, Takenao, Doanh, Le H., Matsushita, Takashi, Obara, Takashi, Kuboi, Yoshikazu, Ishii, Naoto, Machinaga, Akihito, Ogasawara, Hideaki, Ikeda, Wataru, Kawano, Tetsu, Imai, Toshio, Oyama, Noritaka, Hasegawa, Minoru

Volltext

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis von Tanaka, Yoshiya, Takeuchi, Tsutomu, Umehara, Hisanori, Nanki, Toshihiro, Yasuda, Nobuyuki, Tago, Fumitoshi, Kawakubo, Makoto, Kitahara, Yasumi, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio

Volltext

Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease von Nishimura, Miyuki, Kuboi, Yoshikazu, Muramoto, Kenzo, Kawano, Tetsu, Imai, Toshio

Volltext

A phase 2 study of E6011, an anti-Fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to biological disease-modifying antirheumatic drugs von Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio

Volltext

The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury von Mawatari, Seiichi, Moriuchi, Akihiro, Ohba, Fuminori, Kawano, Tetsu, Oda, Kohei, Takikawa, Yasuhiro, Takikawa, Hajime, Ido, Akio, Tsubouchi, Hirohito

Volltext

Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis von Kaneko, Yoshikatsu, Harada, Michishige, Kawano, Tetsu, Yamashita, Masakatsu, Shibata, Youichi, Gejyo, Fumitake, Nakayama, Toshinori, Taniguchi, Masaru

Volltext

Differential tumor surveillance by natural killer (NK) and NKT cells von Smyth, M J, Thia, K Y, Street, S E, Cretney, E, Trapani, J A, Taniguchi, M, Kawano, T, Pelikan, S B, Crowe, N Y, Godfrey, D I

Volltext

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells von Kawano, Tetsu, Cui, Junqing, Koezuka, Yasuhiko, Toura, Isao, Kaneko, Yoshikatsu, Sato, Hiroshi, Kondo, Eisuke, Harada, Michishige, Koseki, Haruhiko, Nakayama, Toshinori, Tanaka, Yujiro, Taniguchi, Masaru

Volltext

Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis von Kitagawa, Yoshihiro, MD, Kikuchi, Shojiro, MD, PhD, Arita, Yoshihisa, MS, Nishimura, Miyuki, Mizuno, Keiko, Ogasawara, Hideaki, Kawano, Tetsu, MD, PhD, Ochiai, Toshiya, MD, PhD, Otsuji, Eigo, MD, PhD, Imai, Toshio, PhD

Volltext

Involvement of decidual Vα14 NKT cells in abortion von Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, Kondo, Eisuke, Sekiya, Souei, Sekikawa, Kenji, Harada, Michishige, Yamashita, Masakatsu, Nakayama, Toshinori, Taniguchi, Masaru

Volltext

Efficacy and Safety of E6011, an Anti‐Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomize... von Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio

Volltext

Phase 1 study on the safety and efficacy of E6011, antifractalkine antibody, in patients with Crohn's disease von Matsuoka, Katsuyoshi, Naganuma, Makoto, Hibi, Toshifumi, Tsubouchi, Hirohito, Oketani, Kiyoshi, Katsurabara, Toshinori, Hojo, Seiichiro, Takenaka, Osamu, Kawano, Tetsu, Imai, Toshio, Kanai, Takanori

Volltext

Serum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112) von Motoi, Sotaro, Uesugi, Mai, Obara, Takashi, Moriya, Katsuhiro, Arita, Yoshihisa, Ogasawara, Hideaki, Soejima, Motohiro, Imai, Toshio, Kawano, Tetsu

Volltext

Long-term safety and efficacy of E6011, an anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to methotrexate von Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio

Volltext

Long-term evaluation of E6011, an anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to biological disease-modifying antirheumatic... von Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio

Volltext

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothr... von Motoi, Sotaro, Toyoda, Hiroko, Obara, Takashi, Ohta, Etsuko, Arita, Yoshihisa, Negishi, Kana, Moriya, Katsuhiro, Kuboi, Yoshikazu, Soejima, Motohiro, Imai, Toshio, Ido, Akio, Tsubouchi, Hirohito, Kawano, Tetsu

Volltext

Histological characteristics of primary biliary cholangitis with an incomplete response to ursodeoxycholic acid von Harada, Kenichi, Kakuda, Yuko, Tanaka, Atsushi, Abe, Masanori, Namisaki, Tadashi, Shimoda, Shinji, Zeniya, Mikio, Ido, Akio, Yoshiji, Hitoshi, Ohira, Hiromasa, Umeda, Atsushi, Kamiya, Yuki, Higashine, Yukari, Hojo, Seiichiro, Imai, Toshio, Kawano, Tetsu, Tsubouchi, Hirohito, Nakanuma, Yasuni

Volltext

FRI155 - Histological characteristics of primary biliary cholangitis with an incomplete response to ursodeoxycholic acid von Harada, Kenichi, Kakuda, Yuko, Tanaka, Atsushi, Abe, Masanori, Namisaki, Tadashi, Shimoda, Shinji, Zeniya, Mikio, Ido, Akio, Yoshiji, Hitoshi, Ohira, Hiromasa, Umeda, Atsushi, Kamiya, Yuki, Higashine, Yukari, Hojo, Seiichiro, Imai, Toshio, Kawano, Tetsu, Tsubouchi, Hirohito, Nakanuma, Yasuni

Volltext

A novel recognition motif of human NKT antigen receptor for a glycolipid ligand von Kawano, Tetsu, Tanaka, Yujiro, Shimizu, Eiko, Kaneko, Yoshikatsu, Kamata, Noriaki, Sato, Hiroshi, Osada, Hisao, Sekiya, Soei, Nakayama, Toshinori, Taniguchi, Masaru

Volltext