Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer von Kauko, Otto, Westermarck, Jukka

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Improved breast milk proteome coverage by DIA based LC‐MS/MS method von Viitaharju, Jenni, Polari, Lauri, Kauko, Otto, Merilahti, Johannes, Rokka, Anne, Toivola, Diana M., Laitinen, Kirsi

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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells von Kauko, O, O'Connor, CM, Kulesskiy, E, Sangodkar, J, Aakula, A, Izadmehr, S, Yetukuri, L, Yadav, B, Padzik, A, Laajala, TD, Haapaniemi, P, Momeny, M, Varila, T, Ohlmeyer, M, Aittokallio, T, Wennerberg, K, Narla, G, Westermarck, J

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Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 von Kauko, Otto, Imanishi, Susumu Y., Kulesskiy, Evgeny, Yetukuri, Laxman, Laajala, Teemu Daniel, Sharma, Mukund, Pavic, Karolina, Aakula, Anna, Rupp, Christian, Jumppanen, Mikael, Haapaniemi, Pekka, Ruan, Luyao, Yadav, Bhagwan, Suni, Veronika, Varila, Taru, Corthals, Garry L., Reimand, Jüri, Wennerberg, Krister, Aittokallio, Tero, Westermarck, Jukka

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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A von Pavic, Karolina, Gupta, Nikhil, Omella, Judit Domènech, Derua, Rita, Aakula, Anna, Huhtaniemi, Riikka, Määttä, Juha A., Höfflin, Nico, Okkeri, Juha, Wang, Zhizhi, Kauko, Otto, Varjus, Roosa, Honkanen, Henrik, Abankwa, Daniel, Köhn, Maja, Hytönen, Vesa P., Xu, Wenqing, Nilsson, Jakob, Page, Rebecca, Janssens, Veerle, Leitner, Alexander, Westermarck, Jukka

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Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia von Oksa, Laura, Mäkinen, Artturi, Nikkilä, Atte, Hyvärinen, Noora, Laukkanen, Saara, Rokka, Anne, Haapaniemi, Pekka, Seki, Masafumi, Takita, Junko, Kauko, Otto, Heinäniemi, Merja, Lohi, Olli

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Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia von Mäkelä, Eleonora, Löyttyniemi, Eliisa, Salmenniemi, Urpu, Kauko, Otto, Varila, Taru, Kairisto, Veli, Itälä-Remes, Maija, Westermarck, Jukka

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PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers von Aakula, Anna, Isomursu, Aleksi, Rupp, Christian, Erickson, Andrew, Gupta, Nikhil, Kauko, Otto, Shah, Pragya, Padzik, Artur, Pokharel, Yuba Raj, Kaur, Amanpreet, Li, Song‐Ping, Trotman, Lloyd, Taimen, Pekka, Rannikko, Antti, Lammerding, Jan, Paatero, Ilkka, Mirtti, Tuomas, Ivaska, Johanna, Westermarck, Jukka

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PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells von Denisova, Oxana V, Merisaari, Joni, Huhtaniemi, Riikka, Qiao, Xi, Yetukuri, Laxman, Jumppanen, Mikael, Kaur, Amanpreet, Pääkkönen, Mirva, von Schantz-Fant, Сarina, Ohlmeyer, Michael, Wennerberg, Krister, Kauko, Otto, Koch, Raphael, Aittokallio, Tero, Taipale, Mikko, Westermarck, Jukka

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A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites von Pihlajamaa, Päivi, Kauko, Otto, Sahu, Biswajyoti, Kivioja, Teemu, Taipale, Jussi

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer von Vervoort, Stephin J., Welsh, Sarah A., Devlin, Jennifer R., Barbieri, Elisa, Knight, Deborah A., Offley, Sarah, Bjelosevic, Stefan, Costacurta, Matteo, Todorovski, Izabela, Kearney, Conor J., Sandow, Jarrod J., Fan, Zheng, Blyth, Benjamin, McLeod, Victoria, Vissers, Joseph H.A., Pavic, Karolina, Martin, Ben P., Gregory, Gareth, Demosthenous, Elena, Zethoven, Magnus, Kong, Isabella Y., Hawkins, Edwin D., Hogg, Simon J., Kelly, Madison J., Newbold, Andrea, Simpson, Kaylene J., Kauko, Otto, Harvey, Kieran F., Ohlmeyer, Michael, Westermarck, Jukka, Gray, Nathanael, Gardini, Alessandro, Johnstone, Ricky W.

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Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56 von Wang, Jiao, Okkeri, Juha, Pavic, Karolina, Wang, Zhizhi, Kauko, Otto, Halonen, Tuuli, Sarek, Grzegorz, Ojala, Päivi M, Rao, Zihe, Xu, Wenqing, Westermarck, Jukka

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Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics von Saraei, Sohrab, Suomi, Tomi, Kauko, Otto, Elo, Laura L

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Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling von Kauko, Otto, Laajala, Teemu Daniel, Jumppanen, Mikael, Hintsanen, Petteri, Suni, Veronika, Haapaniemi, Pekka, Corthals, Garry, Aittokallio, Tero, Westermarck, Jukka, Imanishi, Susumu Y.

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PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression von Liu, Ying, Mattila, Jaakko, Ventelä, Sami, Yadav, Leena, Zhang, Wei, Lamichane, Nicole, Sundström, Jari, Kauko, Otto, Grénman, Reidar, Varjosalo, Markku, Westermarck, Jukka, Hietakangas, Ville

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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A von Pavic, Karolina, Gupta, Nikhil, Domènech Omella, Judit, Derua, Rita, Aakula, Anna, Huhtaniemi, Riikka, Määttä, Juha A, Höfflin, Nico, Okkeri, Juha, Wang, Zhizhi, Kauko, Otto, Varjus, Roosa, Honkanen, Henrik, Abankwa, Daniel, Köhn, Maja, Hytönen, Vesa P, Xu, Wenqing, Nilsson, Jakob, Page, Rebecca, Janssens, Veerle, Leitner, Alexander, Westermarck, Jukka

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Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells von KHANNA, Anchit, KAUKO, Otto, POKHAREL, Yuba R, PIMANDA, John, RUSSEL, Mike R, HAGLUND, Caj, COLE, Kristina A, KLEFSTRÖM, Juha, AITTOKALLIO, Tero, WEISS, Carsten, RISTIMÄKI, Ari, VISAKORPI, Tapio, BÖCKELMAN, Camilla, WESTERMARCK, Jukka, LAINE, Anni, SCHRECK, Ilona, PARTANEN, Johanna I, SZWAJDA, Agnieszka, BORMANN, Stefanie, BILGEN, Turker, HELENIUS, Merja

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Oncoprotein CIP 2A is stabilized via interaction with tumor suppressor PP 2A/B56 von Wang, Jiao, Okkeri, Juha, Pavic, Karolina, Wang, Zhizhi, Kauko, Otto, Halonen, Tuuli, Sarek, Grzegorz, Ojala, Päivi M, Rao, Zihe, Xu, Wenqing, Westermarck, Jukka

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Abstract 5328: Protein phosphatase 2A activity is a major determinant of therapy response in cancer cells von Kauko, Otto, Imanishi, Susumu, Kaur, Amanpreet, Laajala, Daniel, Kulesskiy, Evgeny, Jumppanen, Mikael, Corthals, Garry, Aittokallio, Tero, Wennerberg, Krister, Westermarck, Jukka

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Abstract 5560: Systemic map of protein phosphatase 2A (PP2A)-regulated phosphotargets and drug responses in cancer cells von Kauko, Otto, Imanishi, Susumu, Kulesskiy, Evgeny, Laajala, Teemu D., Yetukuri, Laxmana, Padzik, Artur, Jumppanen, Mikael, Haapaniemi, Pekka, Yadaw, Bhagwan, Suni, Veronika, Varila, Taru, Corthals, Garry, Krister, Wennerberg, Aittokallio, Tero, Westermarck, Jukka

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