The cGAS–STING pathway as a therapeutic target in inflammatory diseases von Decout, Alexiane, Katz, Jason D., Venkatraman, Shankar, Ablasser, Andrea

Volltext

Divergent and Regioselective Synthesis of Pyrazolo[1,5‑a]pyridines and Imidazo[1,5‑a]pyridines von Mennie, Katrina M, Reutershan, Michael H, White, Catherine, Adams, Bruce, Becker, Bridget, Deng, James, Katz, Jason D, LaBlue, Elisabeth, Margrey, Kaila, Saurí, Josep

Volltext

Diastereoselective Alkylations of Oxazolidinone Glycolates:  A Useful Extension of the Evans Asymmetric Alkylation von Crimmins, Michael T, Emmitte, Kyle A, Katz, Jason D

Volltext

Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

Volltext

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators von Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

Volltext

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening von Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.

Volltext

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors von Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.

Volltext

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability von Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

Volltext

Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580] von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

Volltext

Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

Volltext

Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors von Simov, Vladimir, Deshmukh, Sujal V., Dinsmore, Christopher J., Elwood, Fiona, Fernandez, Rafael B., Garcia, Yudith, Gibeau, Craig, Gunaydin, Hakan, Jung, Joon, Katz, Jason D., Kraybill, Brian, Lapointe, Blair, Patel, Sangita B., Siu, Tony, Su, Hua, Young, Jonathan R.

Volltext

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors von Katz, Jason D., Haidle, Andrew, Childers, Kaleen K., Zabierek, Anna A., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Su, Hua-Poo, Munshi, Sanjeev, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

Volltext

Studies towards the total synthesis of palau'amine. Formation of 4,5-dihydropyrrole-2-carboxylate intermediates by alkene–enamide ring-closing metathesis von Katz, Jason D., Overman, Larry E.

Volltext

MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor von PAN, Bo-Sheng, CHAN, Grace K. Y, JEWELL, James P, KARIV, Ilona, KATZ, Jason D, KUNII, Kaiko, WEI LU, LUTTERBACH, Bart A, PAWELETZ, Cloud P, XIANLU QU, REILLY, John F, SZEWCZAK, Alexander A, CHENARD, Melissa, QINWEN ZENG, KOHL, Nancy E, DINSMORE, Christopher J, CHI, An, DAVIS, Lenora J, DESHMUKH, Sujal V, GIBBS, Jackson B, GIL, Susana, GAOZHEN HANG, HATCH, Harold

Volltext

Discovery of a 5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer von Katz, Jason D, Jewell, James P, Guerin, David J, Lim, Jongwon, Dinsmore, Christopher J, Deshmukh, Sujal V, Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D, Dahlberg, William K, Davis, Lenora, Falcone, Danielle, Gabarda, Ana E, Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J, Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B, Qu, Xianlu, Reilly, John F, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Spencer, Kerrie B, Szewczak, Alexander A, Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen

Volltext

Synthesis of the C16−C28 Spiroketal Subunit of Spongistatin 1 (Altohyrtin A):  The Pyrone Approach von Crimmins, Michael T, Katz, Jason D

Volltext

An Aldol Approach to the Synthesis of the EF Fragment of Spongistatin 1 von Crimmins, Michael T, Katz, Jason D, McAtee, Laura C, Tabet, Elie A, Kirincich, Steven J

Volltext

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation von Haidle, Andrew M., Childers, Kaleen K., Zabierek, Anna A., Katz, Jason D., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

Volltext

Preparation of a Stable Trifluoroborate Salt for the Synthesis of 1-Aryl-2,2-difluoro-enolethers and/or 2,2-Difluoro-1-aryl-ketones via Palladium-Mediated Cross-Coupling von Katz, Jason D, Lapointe, Blair T, Dinsmore, Christopher J

Volltext

Asymmetric Total Synthesis of Spongistatins 1 and 2 von Crimmins, Michael T, Katz, Jason D, Washburn, David G, Allwein, Shawn P, McAtee, Laura F

Volltext