A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges von Oshimura, Mitsuo, Uno, Narumi, Kazuki, Yasuhiro, Katoh, Motonobu, Inoue, Toshiaki

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SIRT2 down‐regulation in HeLa can induce p53 accumulation via p38 MAPK activation‐dependent p300 decrease, eventually leading to apoptosis von Li, Yanze, Matsumori, Haruka, Nakayama, Yuji, Osaki, Mitsuhiko, Kojima, Hirotada, Kurimasa, Akihiro, Ito, Hisao, Mori, Seiichi, Katoh, Motonobu, Oshimura, Mitsuo, Inoue, Toshiaki

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Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy von Benedetti, Sara, Uno, Narumi, Hoshiya, Hidetoshi, Ragazzi, Martina, Ferrari, Giulia, Kazuki, Yasuhiro, Moyle, Louise Anne, Tonlorenzi, Rossana, Lombardo, Angelo, Chaouch, Soraya, Mouly, Vincent, Moore, Marc, Popplewell, Linda, Kazuki, Kanako, Katoh, Motonobu, Naldini, Luigi, Dickson, George, Messina, Graziella, Oshimura, Mitsuo, Cossu, Giulio, Tedesco, Francesco Saverio

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Integration-free iPS cells engineered using human artificial chromosome vectors von Hiratsuka, Masaharu, Uno, Narumi, Ueda, Kana, Kurosaki, Hajime, Imaoka, Natsuko, Kazuki, Kanako, Ueno, Etsuya, Akakura, Yutaro, Katoh, Motonobu, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Nakagawa, Masato, Yamanaka, Shinya, Oshimura, Mitsuo

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Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome von Hiratsuka, Masaharu, Ueda, Kana, Uno, Narumi, Uno, Katsuhiro, Fukuhara, Sayaka, Kurosaki, Hajime, Takehara, Shoko, Osaki, Mitsuhiko, Kazuki, Yasuhiro, Kurosawa, Yoshikazu, Nakamura, Takafumi, Katoh, Motonobu, Oshimura, Mitsuo

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SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest von Inoue, Toshiaki, Nakayama, Yuji, Yamada, Hidetoshi, Li, Yanze C., Yamaguchi, Shigeyuki, Osaki, Mitsuhiko, Kurimasa, Akihiro, Hiratsuka, Masaharu, Katoh, Motonobu, Oshimura, Mitsuo

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The transfer of human artificial chromosomes via cryopreserved microcells von Uno, Narumi, Uno, Katsuhiro, Zatti, Susi, Ueda, Kana, Hiratsuka, Masaharu, Katoh, Motonobu, Oshimura, Mitsuo

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Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector von Narai, Takashi, Katoh, Motonobu, Inoue, Toshiaki, Taniguchi, Makoto, Kazuki, Kanako, Kazuki, Yasuhiro, Sato, Kenzo, Kodani, Isamu, Ryoke, Kazuo, Oshimura, Mitsuo

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Construction of a novel human artificial chromosome vector for gene delivery von Katoh, Motonobu, Ayabe, Fumiaki, Norikane, Satoko, Okada, Teruaki, Masumoto, Hiroshi, Horike, Shin-ichi, Shirayoshi, Yasuaki, Oshimura, Mitsuo

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Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer von Katoh, Motonobu, Kazuki, Yasuhiro, Kazuki, Kanako, Kajitani, Naoyo, Takiguchi, Masato, Nakayama, Yuji, Nakamura, Takafumi, Oshimura, Mitsuo

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A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells von Ren, Xianying, Katoh, Motonobu, Hoshiya, Hidetoshi, Kurimasa, Akihiro, Inoue, Toshiaki, Ayabe, Fumiaki, Shibata, Kotaro, Toguchida, Junya, Oshimura, Mitsuo

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Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector von Shitara, Shingo, Kakeda, Minoru, Nagata, Keiko, Hiratsuka, Masaharu, Sano, Akiko, Osawa, Kanako, Okazaki, Akiyo, Katoh, Motonobu, Kazuki, Yasuhiro, Oshimura, Mitsuo, Tomizuka, Kazuma

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SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors von Inoue, Toshiaki, Nakayama, Yuji, Li, Yanze, Matsumori, Haruka, Takahashi, Haruka, Kojima, Hirotada, Wanibuchi, Hideki, Katoh, Motonobu, Oshimura, Mitsuo

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A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning von Ayabe, Fumiaki, Katoh, Motonobu, Inoue, Toshiaki, Kouprina, Natalay, Larionov, Vladimir, Oshimura, Mitsuo

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Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma von Kohda, Masakazu, Hoshiya, Hidetoshi, Katoh, Motonobu, Tanaka, Isao, Masuda, Ryo, Takemura, Tamiko, Fujiwara, Mutsunori, Oshimura, Mitsuo

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Transfer of human artificial chromosome vectors into stem cells von Oshimura, Mitsuo, Katoh, Motonobu

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Heat-regulated production and secretion of insulin from a human artificial chromosome vector von Suda, Tetsuji, Katoh, Motonobu, Hiratsuka, Masaharu, Takiguchi, Masato, Kazuki, Yasuhiro, Inoue, Toshiaki, Oshimura, Mitsuo

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Antigen-mediated growth control of hybridoma cells via a human artificial chromosome von Kawahara, Masahiro, Inoue, Toshiaki, Ren, Xianying, Sogo, Takahiro, Yamada, Hidetoshi, Katoh, Motonobu, Ueda, Hiroshi, Oshimura, Mitsuo, Nagamune, Teruyuki

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Construction of a novel expression system on a human artificial chromosome von Otsuki, Akihiro, Tahimic, Candice G.T., Tomimatsu, Nozomi, Katoh, Motonobu, Chen, David J., Kurimasa, Akihiro, Oshimura, Mitsuo

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Human artificial chromosome vectors meet stem cells von Ren Xianying, Tahimic Candice Ginn T, Katoh Motonobu, Kurimasa Akihiro, Inoue Toshiaki, Oshimura Mitsuo

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