The barrier for proton transport in aquaporins as a challenge for electrostatic models: The role of protein relaxation in mutational calculations von Kato, Mitsunori, Pisliakov, Andrei V., Warshel, Arieh

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Treatment of a Desmoid Tumor That Enlarged During Pregnancy: A Case Report and Literature Review von FUJITA, MASAYUKI, YAMAMOTO, MEGUMI, KAIZAKI, YASUHARU, KATO, MITSUNORI, TSUCHIDA, TORU

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Discovery and Characterization of Allosteric WNK Kinase Inhibitors von Yamada, Ken, Zhang, Ji-Hu, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy Qiongshu, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Gunawan, Jason, Yasoshima, Kayo, Yue, Q. Kimberley, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko I, Deng, Zhan, Park, Hyi-Man

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Apparent NAC Effect in Chorismate Mutase Reflects Electrostatic Transition State Stabilization von Štrajbl, Marek, Shurki, Avital, Kato, Mitsunori, Warshel, Arieh

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Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine von Ishizuka, Tomoko, Fujimori, Izumi, Kato, Mitsunori, Noji-Sakikawa, Chisa, Saito, Motoko, Yoshigae, Yasushi, Kubota, Kazuishi, Kurihara, Atsushi, Izumi, Takashi, Ikeda, Toshihiko, Okazaki, Osamu

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Design and synthesis of lactam–thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors von Barnes-Seeman, David, Boiselle, Carri, Capacci-Daniel, Christina, Chopra, Rajiv, Hoffmaster, Keith, Jones, Christopher T., Kato, Mitsunori, Lin, Kai, Ma, Sue, Pan, Guoyu, Shu, Lei, Wang, Jianling, Whiteman, Leah, Xu, Mei, Zheng, Rui, Fu, Jiping

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Modeling electrostatic effects in proteins von Warshel, Arieh, Sharma, Pankaz K., Kato, Mitsunori, Parson, William W.

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Using a Charging Coordinate in Studies of Ionization Induced Partial Unfolding von Kato, Mitsunori, Warshel, Arieh

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer von LaMarche, Matthew J, Acker, Michael, Argintaru, Andreea, Bauer, Daniel, Boisclair, Julie, Chan, Homan, Chen, Christine Hiu-Tung, Chen, Ying-Nan, Chen, Zhouliang, Deng, Zhan, Dore, Michael, Dunstan, David, Fan, Jianmei, Fekkes, Peter, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Fortin, Pascal D, Fridrich, Cary, Giraldes, John, Glick, Meir, Grunenfelder, Denise, Hao, Huia-Xiang, Hentemann, Martin, Ho, Samuel, Jouk, Andriana, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, Koenig, Robert, LaBonte, Laura R, Larrow, Jay, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Mathieu, Simon, Meyer, Matthew J, Mohseni, Morvarid, Ntaganda, Rukundo, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Reilly, John, Sarver, Patrick, Sellers, William R, Sendzik, Martin, Shultz, Michael D, Slisz, Joanna, Slocum, Kelly, Smith, Troy, Spence, Stanley, Stams, Travis, Straub, Christopher, Tamez, Victoriano, Toure, Bakary-Barry, Towler, Christopher, Wang, Ping, Wang, Hongyun, Williams, Sarah L, Yang, Fan, Yu, Bing, Zhang, Ji-Hu, Zhu, Suzanne

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases von Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R., Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D., Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors von Bagdanoff, Jeffrey T, Chen, Zhouliang, Acker, Michael, Chen, Ying-Nan, Chan, Homan, Dore, Michael, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Shumei, Mohseni, Movarid, Ntaganda, Rukundo, Sarver, Patrick, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, LaMarche, Matthew J

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A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, Kp,uu von Lawrenz, Morgan, Svensson, Mats, Kato, Mitsunori, Dingley, Karen H., Chief Elk, Jackson, Nie, Zhe, Zou, Yefen, Kaplan, Zachary, Lagiakos, H. Rachel, Igawa, Hideyuki, Therrien, Eric

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Combined Free-Energy Calculation and Machine Learning Methods for Understanding Ligand Unbinding Kinetics von Badaoui, Magd, Buigues, Pedro J., Berta, Dénes, Mandana, Gaurav M., Gu, Hankang, Földes, Tamás, Dickson, Callum J., Hornak, Viktor, Kato, Mitsunori, Molteni, Carla, Parsons, Simon, Rosta, Edina

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A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K p,uu von Lawrenz, Morgan, Svensson, Mats, Kato, Mitsunori, Dingley, Karen H, Chief Elk, Jackson, Nie, Zhe, Zou, Yefen, Kaplan, Zachary, Lagiakos, H Rachel, Igawa, Hideyuki, Therrien, Eric

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Dual Allosteric Inhibition of SHP2 Phosphatase von Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R, Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele A, Perez, Lawrence B, Paris, Gregory, Quinn, Christopher M, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael David, Williams, Sarah L, Stams, Travis, Blacklow, Stephen C, Acker, Michael G, LaMarche, Matthew J

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Intrauterine fetal death caused by large placental chorioangioma and hypercoiled umbilical cord: A case report von Sugita, Genki, Tanaka, Masaaki, Kanai, Takahiro, Kobayashi, Hiroto, Hori, Yoshiaki, Kato, Jun, Kato, Mitsunori, Tsuchida, Toru

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A small-molecule inhibitor of C5 complement protein von Jendza, Keith, Kato, Mitsunori, Salcius, Michael, Srinivas, Honnappa, De Erkenez, Andrea, Nguyen, Anh, McLaughlin, Doug, Be, Celine, Wiesmann, Christian, Murphy, Jason, Bolduc, Philippe, Mogi, Muneto, Duca, Jose, Namil, Abdel, Capparelli, Michael, Darsigny, Veronique, Meredith, Erik, Tichkule, Ritesh, Ferrara, Luciana, Heyder, Jessica, Liu, Fang, Horton, Patricia A., Romanowski, Michael J., Schirle, Markus, Mainolfi, Nello, Anderson, Karen, Michaud, Gregory A.

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Bridge Suture for Successful McDonald Emergency Cerclage von Tanaka, Masaaki, Hori, Yoshiaki, Shirafuji, Aya, Kato, Mitsunori, Kato, Jyun, Kobayashi, Hiroto, Tsuchida, Toru, Fukae, Tsukasa

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Abstract 2808: Simultaneous inhibition of SHP2 phosphatase at two allosteric sites von Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R., Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele, Perez, Lawrence, Paris, Greg, Quinn, Christopher, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael, Williams, Sarah, Stams, Travis, Blacklow, Stephen C., LaMarche, Matthew J., Acker, Michael G.

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The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a... von Ehara, Takeru, Adams, Christopher M, Bevan, Doug, Ji, Nan, Meredith, Erik L, Belanger, David B, Powers, James, Kato, Mitsunori, Solovay, Catherine, Liu, Donglei, Capparelli, Michael, Bolduc, Philippe, Grob, Jonathan E, Daniels, Matthew H, Ferrara, Luciana, Yang, Louis, Li, Byron, Towler, Christopher S, Stacy, Rebecca C, Prasanna, Ganesh, Mogi, Muneto

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