Differential fates of biomolecules delivered to target cells via extracellular vesicles von Kanada, Masamitsu, Bachmann, Michael H., Hardy, Jonathan W., Frimannson, Daniel Omar, Bronsart, Laura, Wang, Andrew, Sylvester, Matthew D., Schmidt, Tobi L., Kaspar, Roger L., Butte, Manish J., Matin, A. C., Contag, Christopher H.

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Keratin 16 regulates innate immunity in response to epidermal barrier breach von Lessard, Juliane C., Piña-Paz, Sylvia, Rotty, Jeremy D., Hickerson, Robyn P., Kaspar, Roger L., Balmain, Allan, Coulombe, Pierre A.

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In Vivo Sustained Release of siRNA from Solid Lipid Nanoparticles von Lobovkina, Tatsiana, Jacobson, Gunilla B, Gonzalez-Gonzalez, Emilio, Hickerson, Robyn P, Leake, Devin, Kaspar, Roger L, Contag, Christopher H, Zare, Richard N

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Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes von Kerns, Michelle L, Hakim, Jill M C, Lu, Rosemary G, Guo, Yajuan, Berroth, Andreas, Kaspar, Roger L, Coulombe, Pierre A

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First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder von Leachman, Sancy A, Hickerson, Robyn P, Schwartz, Mary E, Bullough, Emily E, Hutcherson, Stephen L, Boucher, Kenneth M, Hansen, C David, Eliason, Mark J, Srivatsa, G Susan, Kornbrust, Douglas J, Smith, Frances JD, McLean, WH Irwin, Milstone, Leonard M, Kaspar, Roger L

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Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells von Geihe, Erika I, Cooley, Christina B, Simon, Jeff R, Kiesewetter, Matthew K, Edward, Justin A, Hickerson, Robyn P, Kaspar, Roger L, Hedrick, James L, Waymouth, Robert M, Wender, Paul A

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Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita von Leachman, Sancy A, Hickerson, Robyn P, Hull, Peter R, Smith, Frances J.D, Milstone, Leonard M, Lane, E. Birgitte, Bale, Sherri J, Roop, Dennis R, McLean, W.H. Irwin, Kaspar, Roger L

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Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients von Hickerson, Robyn P, Leake, Devin, Pho, Lana N, Leachman, Sancy A, Kaspar, Roger L

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An appraisal of oral retinoids in the treatment of pachyonychia congenita von Gruber, Robert, MD, Edlinger, Michael, MSc, Kaspar, Roger L., PhD, Hansen, C. David, MD, Leachman, Sancy, MD, PhD, Milstone, Leonard M., MD, Smith, Frances J.D., PhD, Sidoroff, Alexis, MD, Fritsch, Peter O., MD, Schmuth, Matthias, MD

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Use of Self-Delivery siRNAs to Inhibit Gene Expression in an Organotypic Pachyonychia Congenita Model von Hickerson, Robyn P., Flores, Manuel A., Leake, Devin, Lara, Maria F., Contag, Christopher H., Leachman, Sancy A., Kaspar, Roger L.

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Inhibition of CD44 Gene Expression in Human Skin Models, Using Self-Delivery Short Interfering RNA Administered by Dissolvable Microneedle Arrays von LARA, Maria Fernanda, GONZALEZ-GONZALEZ, Emilio, SPEAKER, Tycho J, HICKERSON, Robyn P, LEAKE, Devin, MILSTONE, Leonard M, CONTAG, Christopher H, KASPAR, Roger L

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Gene expression profiling in pachyonychia congenita skin von Cao, Yu-An, Hickerson, Robyn P, Seegmiller, Brandon L, Grapov, Dmitry, Gross, Maren M, Bessette, Marc R, Phinney, Brett S, Flores, Manuel A, Speaker, Tycho J, Vermeulen, Annaleen, Bravo, Albert A, Bruckner, Anna L, Milstone, Leonard M, Schwartz, Mary E, Rice, Robert H, Kaspar, Roger L

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Clinical and Pathological Features of Pachyonychia Congenita von Leachman, Sancy A., Kaspar, Roger L., Fleckman, Philip, Florell, Scott R., Smith, Frances J.D., McLean, W.H. Irwin, Lunny, Declan P., Milstone, Leonard M., van Steensel, Maurice A.M., Munro, Colin S., O'Toole, Edel A., Celebi, Julide T., Kansky, Aleksej, Lane, EBirgitte

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Development of Therapeutic siRNAs for Pachyonychia Congenita von Smith, Frances J.D., Hickerson, Robyn P., Sayers, Jane M., Reeves, Robert E., Contag, Christopher H., Leake, Devin, Kaspar, Roger L., Irwin McLean, W.H.

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Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model von Wang, Qian, Contag, Christopher H, Ilves, Heini, Johnston, Brian H, Kaspar, Roger L

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Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept von Chong, Rosalind H.E., Gonzalez-Gonzalez, Emilio, Lara, Maria F., Speaker, Tycho J., Contag, Christopher H., Kaspar, Roger L., Coulman, Sion A., Hargest, Rachel, Birchall, James C.

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Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device von Hickerson, Robyn P, Wey, Winston C, Rimm, David L, Speaker, Tycho, Suh, Susie, Flores, Manuel A, Gonzalez-Gonzalez, Emilio, Leake, Devin, Contag, Christopher H, Kaspar, Roger L

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Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope von Ra, Hyejun, Gonzalez-Gonzalez, Emilio, Smith, Bryan R, Gambhir, Sanjiv S, Kino, Gordon S, Solgaard, Olav, Kaspar, Roger L, Contag, Christopher H

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Identification of AUF1 as a rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs von Kakegawa, Tomohito, Ohuchi, Nozomi, Hayakawa, Akiko, Hirata, Satoru, Matsuda, Megumi, Kogure, Keiko, Kobayashi, Hiroshi, Inoue, Akira, Kaspar, Roger L.

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Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD) von Gonzalez-Gonzalez, Emilio, Speaker, Tycho J, Hickerson, Robyn P, Spitler, Ryan, Flores, Manuel A, Leake, Devin, Contag, Christopher H, Kaspar, Roger L

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