Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza von Chivukula, Sudha, Plitnik, Timothy, Tibbitts, Timothy, Karve, Shrirang, Dias, Anusha, Zhang, Donghui, Goldman, Rebecca, Gopani, Hardip, Khanmohammed, Asad, Sarode, Ashish, Cooper, Dustin, Yoon, Heesik, Kim, Younghoon, Yan, Yanhua, Mundle, Sophia T., Groppo, Rachel, Beauvais, Adrien, Zhang, Jinrong, Anosova, Natalie G., Lai, Charles, Li, Lu, Ulinski, Gregory, Piepenhagen, Peter, DiNapoli, Joshua, Kalnin, Kirill V., Landolfi, Victoria, Swearingen, Ron, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

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Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis von Werner, Michael E, Karve, Shrirang, Sukumar, Rohit, Cummings, Natalie D, Copp, Jonathan A, Chen, Ronald C, Zhang, Tian, Wang, Andrew Z

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Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery von Karve, Shrirang, Werner, Michael E., Sukumar, Rohit, Cummings, Natalie D., Copp, Jonathan A., Wang, Edina C., Li, Chenxi, Sethi, Manish, Chen, Ronald C., Pacold, Michael E., Wang, Andrew Z.

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Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models von Kalnin, Kirill V., Plitnik, Timothy, Kishko, Michael, Zhang, Jinrong, Zhang, Donghui, Beauvais, Adrien, Anosova, Natalie G., Tibbitts, Tim, DiNapoli, Josh, Ulinski, Gregory, Piepenhagen, Peter, Cummings, Sheila M., Bangari, Dinesh S., Ryan, Susan, Huang, Po-Wei D., Huleatt, James, Vincent, Deanne, Fries, Katherine, Karve, Shrirang, Goldman, Rebecca, Gopani, Hardip, Dias, Anusha, Tran, Khang, Zacharia, Minnie, Gu, Xiaobo, Boeglin, Lianne, Abysalh, Jonathan, Vargas, Jorel, Beaulieu, Angela, Shah, Monic, Jeannotte, Travis, Gillis, Kimberly, Chivukula, Sudha, Swearingen, Ron, Landolfi, Victoria, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

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mRNA therapeutics: beyond vaccine applications von Bhat, Balkrishen, Karve, Shrirang, Anderson, Daniel G.

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Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation von Vaidya, Amita, Parande, Dipen, Khadse, Nikita, Vargas-Montoya, Natalia, Agarwal, Vikram, Ortiz, Christian, Ellis, Gordon, Kaushal, Neha, Sarode, Ashish, Karve, Shrirang, DeRosa, Frank

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Understanding structure activity relationships of Good HEPES lipids for lipid nanoparticle mRNA vaccine applications von Goldman, Rebecca L., Vittala Murthy, Namratha Turuvekere, Northen, Trent P., Balakrishnan, Anuranjani, Chivukula, Sudha, Danz, Hillary, Tibbitts, Timothy, Dias, Anusha, Vargas, Jorel, Cooper, Dustin, Gopani, Hardip, Beaulieu, Angela, Kalnin, Kirill V., Plitnik, Timothy, Karmakar, Saswata, Dasari, Ramesh, Landis, Ryan, Karve, Shrirang, DeRosa, Frank

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Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery von Sarode, Ashish, Patel, Priyal, Vargas-Montoya, Natalia, Allawzi, Ayed, Zhilin-Roth, Alisa, Karmakar, Saswata, Boeglin, Lianne, Deng, Hongfeng, Karve, Shrirang, DeRosa, Frank

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Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin von Bandekar, Amey, Karve, Shrirang, Chang, Min-Yuan, Mu, Qingshan, Rotolo, Jimmy, Sofou, Stavroula

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Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity von Sethi, Manish, Sukumar, Rohit, Karve, Shrirang, Werner, Michael E, Wang, Edina C, Moore, Dominic T, Kowalczyk, Sonya R, Zhang, Liangfang, Wang, Andrew Z

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Folate-Targeted Polymeric Nanoparticle Formulation of Docetaxel Is an Effective Molecularly Targeted Radiosensitizer with Efficacy Dependent on the Timing of Radiotherapy von Werner, Michael E, Copp, Jonathan A, Karve, Shrirang, Cummings, Natalie D, Sukumar, Rohit, Li, Chenxi, Napier, Mary E, Chen, Ronald C, Cox, Adrienne D, Wang, Andrew Z

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Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model von Kalnin, Kirill V., Plitnik, Timothy, Kishko, Michael, Huang, Dean, Raillard, Alice, Piolat, Julie, Anosova, Natalie G., Tibbitts, Timothy, DiNapoli, Joshua, Karve, Shrirang, Goldman, Rebecca, Gopani, Hardip, Dias, Anusha, Tran, Khang, Zacharia, Minnie, Gu, Xiaobo, Boeglin, Lianne, Abysalh, Jonathan, Vargas, Jorel, Beaulieu, Angela, Shah, Monic, Jeannotte, Travis, Gillis, Kimberly, Chivukula, Sudha, Swearingen, Ron, Landolfi, Victoria, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

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The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity von Karve, Shrirang, Bandekar, Amey, Ali, Md. R, Sofou, Stavroula

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Abstract 374: Nanoparticle formulation of wortmannin as a novel radiosensitizer von Karve, Shrirang, Werner, Michael, Sukumar, Rohit, Cummings, Natalie, Wang, Andrew

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pH-Dependent Formation of Lipid Heterogeneities Controls Surface Topography and Binding Reactivity in Functionalized Bilayers von Kempegowda, Gautam Bajagur, Karve, Shrirang, Bandekar, Amey, Adhikari, Arjun, Khaimchayev, Tamara, Sofou, Stavroula

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Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicityElectronic supplementary information (ESI) available: NP size distribution, DLS analysis showing NP... von Sethi, Manish, Sukumar, Rohit, Karve, Shrirang, Werner, Michael E, Wang, Edina C, Moore, Dominic T, Kowalczyk, Sonya R, Zhang, Liangfang, Wang, Andrew Z

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Abstract 382: Evaluation of folate-targeted ChemoRad nanoparticle as intraperitoneal chemoradiotherapy for ovarian cancer von Werner, Michael E., Karve, Shrirang, Sukumar, Rohit, Cummings, Natalie D., Wang, Andrew Z.

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TES-BASED CATIONIC LIPIDS von DEROSA, Frank, KARVE, Shrirang

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TES-BASED CATIONIC LIPIDS von DEROSA, Frank, KARVE, Shrirang

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Heterogeneous Domains and Membrane Permeability in Phosphatidylcholine−Phosphatidic Acid Rigid Vesicles As a Function of pH and Lipid Chain Mismatch von Karve, Shrirang, Bajagur Kempegowda, Gautam, Sofou, Stavroula

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