Molecular Pathways: Targeting ATR in Cancer Therapy von Karnitz, Larry M, Zou, Lee

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Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity von Kurmi, Kiran, Hitosugi, Sadae, Wiese, Elizabeth K., Boakye-Agyeman, Felix, Gonsalves, Wilson I., Lou, Zhenkun, Karnitz, Larry M., Goetz, Matthew P., Hitosugi, Taro

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1 von Delacroix, Sinny, Wagner, Jill M, Kobayashi, Masahiko, Yamamoto, Ken-ichi, Karnitz, Larry M

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ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status von HUNTOON, Catherine J, FLATTEN, Karen S, WAHNER HENDRICKSON, Andrea E, HUEHLS, Amelia M, SUTOR, Shari L, KAUFMANN, Scott H, KARNITZ, Larry M

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Cisplatin-Induced DNA Damage Activates Replication Checkpoint Signaling Components that Differentially Affect Tumor Cell Survival von Wagner, Jill M, Karnitz, Larry M

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RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network von Geng, Liyi, Huntoon, Catherine J, Karnitz, Larry M

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DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer von Chowdhury, Shrabanti, Wang, Ru, Yu, Qing, Huntoon, Catherine J, Karnitz, Larry M, Kaufmann, Scott H, Gygi, Steven P, Birrer, Michael J, Paulovich, Amanda G, Peng, Jie, Wang, Pei

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ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer von Kanakkanthara, Arun, Huntoon, Catherine J., Hou, Xiaonan, Zhang, Minzhi, Heinzen, Ethan P., O’Brien, Daniel R., Oberg, Ann L., John Weroha, S., Kaufmann, Scott H., Karnitz, Larry M.

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A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia von Pratz, Keith W, Rudek, Michelle A, Gojo, Ivana, Litzow, Mark R, McDevitt, Michael A, Ji, Jiuping, Karnitz, Larry M, Herman, James G, Kinders, Robert J, Smith, B Douglas, Gore, Steven D, Carraway, Hetty E, Showel, Margaret M, Gladstone, Douglas E, Levis, Mark J, Tsai, Hua-Ling, Rosner, Gary, Chen, Alice, Kaufmann, Scott H, Karp, Judith E

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Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect von Wiese, Elizabeth K., Hitosugi, Sadae, Loa, Sharon T., Sreedhar, Annapoorna, Andres-Beck, Lindsey G., Kurmi, Kiran, Pang, Yuan-Ping, Karnitz, Larry M., Gonsalves, Wilson I., Hitosugi, Taro

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Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil von Geng, Liyi, Huehls, Amelia M, Wagner, Jill M, Huntoon, Catherine J, Karnitz, Larry M

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Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway von HUNTOON, Catherine J, NYE, Monica D, LIYI GENG, PETERSON, Kevin L, FLATTEN, Karen S, HALUSKA, Paul, KAUFMANN, Scott H, KARNITZ, Larry M

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Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Pol... von Joshi, Poorval M., Sutor, Shari L., Huntoon, Catherine J., Karnitz, Larry M.

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Pharmacological Abrogation of S-Phase Checkpoint Enhances the Anti-Tumor Activity of Gemcitabine In Vivo von Matthews, David J., Yakes, Michael, Chen, Jason, Tadano, Michele, Bornheim, Lester, Clary, Douglas O., Tai, Albert, Wagner, Jill M., Miller, Nicole, Kim, Yong D., Robertson, Scott, Murray, Louis, Karnitz, Larry M.

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Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress von Arlander, Sonnet J.H., Eapen, Alex K., Vroman, Benjamin T., McDonald, Robert J., Toft, David O., Karnitz, Larry M.

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VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases von Ekstrom, Thomas L., Pathoulas, Nicholas M., Huehls, Amelia M., Kanakkanthara, Arun, Karnitz, Larry M.

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The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons von Flatten, Karen, Dai, Nga T., Vroman, Benjamin T., Loegering, David, Erlichman, Charles, Karnitz, Larry M., Kaufmann, Scott H.

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Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones von Arlander, Sonnet J.H., Felts, Sara J., Wagner, Jill M., Stensgard, Bridget, Toft, David O., Karnitz, Larry M.

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Gemcitabine-Induced Activation of Checkpoint Signaling Pathways That Affect Tumor Cell Survival von Karnitz, Larry M, Flatten, Karen S, Wagner, Jill M, Loegering, David, Hackbarth, Jennifer S, Arlander, Sonnet J H, Vroman, Benjamin T, Thomas, M Bijoy, Baek, Yong-Un, Hopkins, Kevin M, Lieberman, Howard B, Chen, Junjie, Cliby, William A, Kaufmann, Scott H

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Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia von KAUFMANN, Scott H, KARP, Judith E, MAURER, Matthew J, DOUGLAS SMITH, B, GREER, Jacqueline, YUHONG CHEN, REID, Joel M, PERCY IVY, S, AMES, Matthew M, ADJEI, Alex A, ERLICHMAN, Charles, KARNITZ, Larry M, LITZOW, Mark R, MESA, Ruben A, HOGAN, William, STEENSMA, David P, FLATTEN, Karen S, LOEGERING, David A, SCHNEIDER, Paula A, PETERSON, Kevin L

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