Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates von Zhao, Hui, Atkinson, John, Gulesserian, Sara, Zeng, Zhilan, Nater, Jenny, Ou, Jimmy, Yang, Peng, Morrison, Karen, Coleman, Jeffrey, Malik, Faisal, Challita-Eid, Pia, Karki, Sher, Aviña, Hector, Hubert, René, Capo, Linnette, Snyder, Josh, Moon, Sung-Ju, Luethy, Roland, Mendelsohn, Brian A, Stover, David R, Doñate, Fernando

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Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models von Challita-Eid, Pia M, Satpayev, Daulet, Yang, Peng, An, Zili, Morrison, Karen, Shostak, Yuriy, Raitano, Arthur, Nadell, Rossana, Liu, Wendy, Lortie, Dawn Ratay, Capo, Linnette, Verlinsky, Alla, Leavitt, Monica, Malik, Faisal, Aviña, Hector, Guevara, Claudia I, Dinh, Nick, Karki, Sher, Anand, Banmeet S, Pereira, Daniel S, Joseph, Ingrid B J, Doñate, Fernando, Morrison, Kendall, Stover, David R

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Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia von Zhao, Hui, Gulesserian, Sara, Ganesan, Sathish Kumar, Ou, Jimmy, Morrison, Karen, Zeng, Zhilan, Robles, Veronica, Snyder, Josh, Do, Lisa, Aviña, Hector, Karki, Sher, Stover, David R, Doñate, Fernando

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Enhanced antibody half-life improves in vivo activity von Karki, Sher, Leung, Irene W L, Horton, Holly M, Chamberlain, Aaron K, Roopenian, Derry C, Desjarlais, John R, Lazar, Greg A, Zalevsky, Jonathan, Sproule, Thomas J

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Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells von Richards, John O., Karki, Sher, Lazar, Greg A., Chen, Hsing, Dang, Wei, Desjarlais, John R.

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Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions von Moore, Gregory L., Chen, Hsing, Karki, Sher, Lazar, Greg A.

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Engineered Antibody Fc Variants with Enhanced Effector Function von Lazar, Greg A., Dang, Wei, Karki, Sher, Vafa, Omid, Peng, Judy S., Hyun, Linus, Chan, Cheryl, Chung, Helen S., Eivazi, Araz, Yoder, Sean C., Vielmetter, Jost, Carmichael, David F., Hayes, Robert J., Dahiyat, Bassil I.

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Cytoplasmic dynein and dynactin in cell division and intracellular transport von Karki, Sher, Holzbaur, Erika LF

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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens von Moore, Gregory L., Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S., Karki, Sher, Chu, Seung Y., Lazar, Greg A.

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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies von Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.

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1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity von Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R

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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function von Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.

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A molecular immunology approach to antibody humanization and functional optimization von Lazar, Greg A., Desjarlais, John R., Jacinto, Jonathan, Karki, Sher, Hammond, Philip W.

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The Interaction between Cytoplasmic Dynein and Dynactin is Required for Fast Axonal Transport von Waterman-Storer, C M, Karki, S B, Kuznetsov, S A, Tabb, J S, Weiss, D G, Langford, G M, Holzbaur, E L

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Affinity Chromatography Demonstrates a Direct Binding between Cytoplasmic Dynein and the Dynactin Complex von Karki, Sher, Holzbaur, Erika L.F.

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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia von HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland

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AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML von Pereira, Daniel S, Guevara, Claudia I, Jin, Liqing, Mbong, Nathan, Verlinsky, Alla, Hsu, Ssucheng J, Aviña, Hector, Karki, Sher, Abad, Joseph D, Yang, Peng, Moon, Sung-Ju, Malik, Faisal, Choi, Michael Y, An, Zili, Morrison, Kendall, Challita-Eid, Pia M, Doñate, Fernando, Joseph, Ingrid B J, Kipps, Thomas J, Dick, John E, Stover, David R

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AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma von Doñate, Fernando, Raitano, Arthur, Morrison, Kendall, An, Zili, Capo, Linnette, Aviña, Hector, Karki, Sher, Morrison, Karen, Yang, Peng, Ou, Jimmy, Moriya, Ryuichi, Shostak, Yuriy, Malik, Faisal, Nadell, Rossana, Liu, Wendy, Satpayev, Daulet, Atkinson, John, Joseph, Ingrid B J, Pereira, Daniel S, Challita-Eid, Pia M, Stover, David R

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A Dynactin Subunit with a Highly Conserved Cysteine-rich Motif Interacts Directly with Arp1 von Karki, Sher, Tokito, Mariko K., Holzbaur, Erika L.F.

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Casein Kinase II Binds to and Phosphorylates Cytoplasmic Dynein von Karki, Sher, Tokito, Mariko K., Holzbaur, ErikaL. F.

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