Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor von Perera, Timothy P S, Jovcheva, Eleonora, Mevellec, Laurence, Vialard, Jorge, De Lange, Desiree, Verhulst, Tinne, Paulussen, Caroline, Van De Ven, Kelly, King, Peter, Freyne, Eddy, Rees, David C, Squires, Matthew, Saxty, Gordon, Page, Martin, Murray, Christopher W, Gilissen, Ron, Ward, George, Thompson, Neil T, Newell, David R, Cheng, Na, Xie, Liang, Yang, Jennifer, Platero, Suso J, Karkera, Jayaprakash D, Moy, Christopher, Angibaud, Patrick, Laquerre, Sylvie, Lorenzi, Matthew V

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Oncogenic Characterization and Pharmacologic Sensitivity of Activating Fibroblast Growth Factor Receptor (FGFR) Genetic Alterations to the Selective FGFR Inhibitor Erdafitinib von Karkera, Jayaprakash D, Cardona, Gabriela Martinez, Bell, Katherine, Gaffney, Dana, Portale, Joseph C, Santiago-Walker, Ademi, Moy, Christopher H, King, Peter, Sharp, Michael, Bahleda, Rastislav, Luo, Feng R, Alvarez, John D, Lorenzi, Matthew V, Platero, Suso J

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Reduced NODAL Signaling Strength via Mutation of Several Pathway Members Including FOXH1 Is Linked to Human Heart Defects and Holoprosencephaly von Roessler, Erich, Ouspenskaia, Maia V., Karkera, Jayaprakash D., Vélez, Jorge I., Kantipong, Amy, Lacbawan, Felicitas, Bowers, Peter, Belmont, John W., Towbin, Jeffrey A., Goldmuntz, Elizabeth, Feldman, Benjamin, Muenke, Maximilian

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The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study von Karkera, Jayaprakash, Steiner, Hannes, Li, Weimin, Skradski, Viktor, Moser, Patrizia L., Riethdorf, Sabine, Reddy, Manjula, Puchalski, Thomas, Safer, Karim, Prabhakar, Uma, Pantel, Klaus, Qi, Ming, Culig, Zoran

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Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly von Roessler, Erich, Pei, Wuhong, Ouspenskaia, Maia V., Karkera, Jayaprakash D., Veléz, Jorge Ivan, Banerjee-Basu, Sharmilla, Gibney, Gretchen, Lupo, Philip J., Mitchell, Laura E., Towbin, Jeffrey A., Bowers, Peter, Belmont, John W., Goldmuntz, Elizabeth, Baxevanis, Andreas D., Feldman, Benjamin, Muenke, Maximilian

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CFC1 Mutations in Patients with Transposition of the Great Arteries and Double-Outlet Right Ventricle von Goldmuntz, Elizabeth, Bamford, Richard, Karkera, Jayaprakash D., dela Cruz, June, Roessler, Erich, Muenke, Maximilian

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Prespecified Candidate Biomarkers Identify Follicular Lymphoma Patients Who Achieved Longer Progression-Free Survival with Bortezomib―Rituximab Versus Rituximab von COIFFIER, Bertrand, WEIMIN LI, SCHAFFER, Michael E, OSMANOV, Evgenii A, XIAONAN HONG, SCHELIGA, Adriana, MAYER, Jiri, OFFNER, Fritz, RULE, Simon, TEIXEIRA, Adriana, ROMEJKO-JAROSINSKA, Joanna, DE VOS, Sven, HENITZ, Erin D, CRUMP, Michael, SHPILBERG, Ofer, ZINZANI, Pier Luigi, CAKANA, Andrew, ESSELTINE, Dixie-Lee, MULLIGAN, George, RICCI, Deborah, KARKERA, Jayaprakash D, FAVIS, Reyna, GAFFNEY, Dana, SHAPIRO, Alice, THEOCHAROUS, Panteli, ELSAYED, Yusri A, VAN DE VELDE, Helgi

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A High-Density Genome Scan Detects Evidence for a Bipolar-Disorder Susceptibility Locus on 13q32 and Other Potential Loci on 1q32 and 18p11.2 von Detera-Wadleigh, Sevilla D., Badner, Judith A., Berrettini, Wade H., Yoshikawa, Takeo, Goldin, Lynn R., Turner, Gordon, Rollins, Denise Y., Moses, Tracy, Sanders, Alan R., Karkera, Jayaprakash D., Esterling, Lisa E., Zeng, Jin, Ferraro, Thomas N., Guroff, Juliet J., Kazuba, Diane, Maxwell, Mary E., Nurnberger, John I., Gershon, Elliot S.

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Clinical Validation of Companion Diagnostics for the Selection of Patients with Non–Small Cell Lung Cancer Tumors Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutat... von Jatkoe, Timothy, Wang, Songbai, Odegaard, Justin I., Velasco Roth, Anne Marie, Osgood, Drew, Martinez, Gabriela, Lucas, Paul, Curtin, Joshua C., Karkera, Jayaprakash

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The Anti-Interleukin-6 Antibody Siltuximab Down-Regulates Genes Implicated inTumorigenesis in Prostate Cancer Patients From a Phase I Study von KARKERA, Jayaprakash, STEINER, Hannes, PANTEL, Klaus, MING QI, CULIG, Zoran, WEIMIN LI, SKRADSKI, Viktor, MOSER, Patrizia L, RIETHDORF, Sabine, REDDY, Manjula, PUCHALSKI, Thomas, SAFER, Karim, PRABHAKAR, Uma

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Abstract 5027: Detection of soluble protein biomarkers in NSCLC serum samples by meso scale discovery electrochemiluminescence platform von Gaffney, Dana S., Bell, Katherine, Martinez, Gabriela, Karkera, Jayaprakash, Platero, Suso

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Abstract 5538: Arv7 validation in castrate resistant prostate tumors utilizing Rnascope in situ hybridization assay von Cash-Mason, Tanesha, Wong, Jackson, Martinez, Martinez, Sharp, Michael, Karkera, Jayaprakash, Alvarez, John D., Chu, Gerald C., Thomas, Shibu, Li, Weiman, Tian, S. Ken

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Abstract 4326: Co-amplification of FGF receptors and ligands in FGFR inhibitor-sensitive cell lines von Bell, Katherine, Gaffney, Dana, Martinez-Cardona, Gabriela, Karkera, Jayaprakash, Platero, Suso

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Abstract 4325: The role of FGFR fusion genes as novel oncogenic targets von Martinez Cardona, Gabriela, Bell, Katherine, Gaffney, Dana, Portale, Joseph, Platero, Suso, Lorenzi, Matthew, Karkera, Jayaprakash

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Abstract 3990: FGFR3 mutations as novel oncogenic targets von Martinez Cardona, Gabriela, Gaffney, Dana, Bell, Katherine, Portale, Joseph, Dunworth, Matthew, Lorenzi, Matthew, Platero, Suso, Karkera, Jayaprakash

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Abstract 3174: A real-time qPCR approach to detect fusions between the KIF5B and RET genes in non-small cell lung cancer von Bell, Katherine, Gaffney, Dana, Martinez, Gabriela, Platero, Suso, Karkera, Jayaprakash

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Abstract 4666: Profiling mesothelin protein expression by immunohistochemistry and gene expression in adenocarcinoma and squamous cell carcinoma of lung von Wong, Jackson, Gaffney, Dana, Sharp, Michael, Hertzog, Brenda, Karkera, Jayaprakash, Platero, Suso, Alvarez, John

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Abstract 1548: Genomic and molecular profiling of NSCLC formalin-fixed paraffin-embedded tumors von Gaffney, Dana S., Bell, Katherine, Martinez, Gabriela, Rajpurohit, Yashoda, Karkera, Jayaprakash, Moy, Christopher, Platero, Suso

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Abstract B03: Identification of R-spondin fusions in NSCLC von Karkera, Jayaprakash, Martinez, Gabriela, Bell, Katherine, Portale, Joseph, Gaffney, Dana, Lorenzi, Matthew V., Platero, Suso

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Abstract 2408: Identification of R-Spondin fusions in various types of human cancer von Cardona, Gabriela Martinez, Bell, Katherine, Portale, Joseph, Gaffney, Dana, Moy, Christopher, Platero, Suso, Lorenzi, Matthew V., Karkera, Jayaprakash

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