SARS-CoV-2 Variants of Concern and Variants of Interest Receptor Binding Domain Mutations and Virus Infectivity von Liu, Haolin, Wei, Pengcheng, Kappler, John W, Marrack, Philippa, Zhang, Gongyi

Volltext

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance von Rubtsova, Kira, Rubtsov, Anatoly V., van Dyk, Linda F., Kappler, John W., Marrack, Philippa

Volltext

Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity von Rubtsov, Anatoly V., Rubtsova, Kira, Fischer, Aryeh, Meehan, Richard T., Gillis, Joann Z., Kappler, John W., Marrack, Philippa

Volltext

Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity von Clayton, Gina M., Wang, Yang, Crawford, Frances, Novikov, Andrey, Wimberly, Brian T., Kieft, Jeffrey S., Falta, Michael T., Bowerman, Natalie A., Marrack, Philippa, Fontenot, Andrew P., Dai, Shaodong, Kappler, John W.

Volltext

Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse von Crawford, Frances, Stadinski, Brian, Jin, Niyun, Michels, Aaron, Nakayama, Maki, Pratt, Philip, Marrack, Philippa, Eisenbarth, George, Kappler, John W.

Volltext

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes von Yang, Junbao, Chow, I-Ting, Sosinowski, Tomasz, Torres-Chinn, Nadia, Greenbaum, Carla J., James, Eddie A., Kappler, John W., Davidson, Howard W., Kwok, William W.

Volltext

Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation von Fontenot, Andrew P, Falta, Michael T, Kappler, John W, Dai, Shaodong, McKee, Amy S

Volltext

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells von McKee, Amy S, Burchill, Matthew A, Munks, Michael W, Jin, Lei, Kappler, John W, Friedman, Rachel S, Jacobelli, Jordan, Marrack, Philippa

Volltext

Chromogranin A is an autoantigen in type 1 diabetes von Reisdorph, Nichole, Stadinski, Brian D, Crawford, Frances, Haskins, Kathryn, Delong, Thomas, Powell, Roger L, Kappler, John W, Bradley, Brenda, Reisdorph, Richard, Marrack, Philippa, Piganelli, Jon D, Armstrong, Michael, Barbour, Gene, Mahata, Sushil K

Volltext

Genetic and hormonal factors in female-biased autoimmunity von Rubtsov, Anatoly V, Rubtsova, Kira, Kappler, John W, Marrack, Philippa

Volltext

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers von Yin, Lei, Huseby, Eric, Scott-Browne, James, Rubtsova, Kira, Pinilla, Clamencia, Crawford, Frances, Marrack, Philippa, Dai, Shaodong, Kappler, John W.

Volltext

Hidden in Plain View: Discovery of Chimeric Diabetogenic CD4 T Cell Neo-Epitopes von Reed, Brendan K, Kappler, John W

Volltext

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses von Rubtsova, Kira, Rubtsov, Anatoly V, Halemano, Kalani, Li, Sam X, Kappler, John W, Santiago, Mario L, Marrack, Philippa

Volltext

N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes von Jin, Niyun, Wang, Yang, Crawford, Frances, White, Janice, Marrack, Philippa, Dai, Shaodong, Kappler, John W.

Volltext

Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6 von Clayton, Gina M, White, Janice, Lee, Schuyler, Kappler, John W, Chan, Sanny K

Volltext

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects von Nakayama, Maki, McDaniel, Kristen, Fitzgerald-Miller, Lisa, Carol, Kiekhaefer, Snell-Bergeona, Janet K., Davidson, Howard W., Rewers, Marian, Yu, Liping, Gottlieb, Peter, Kappler, John W., Michels, Aaron

Volltext

Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells von MacLeod, Megan K.L, McKee, Amy S, David, Alexandria, Wang, Jieru, Mason, Robert, Kappler, John W, Marrack, Philippa

Volltext

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion von Ranasinghe, Srinika, Lamothe, Pedro A., Soghoian, Damien Z., Kazer, Samuel W., Cole, Michael B., Shalek, Alex K., Yosef, Nir, Jones, R. Brad, Donaghey, Faith, Nwonu, Chioma, Jani, Priya, Clayton, Gina M., Crawford, Frances, White, Janice, Montoya, Alana, Power, Karen, Allen, Todd M., Streeck, Hendrik, Kaufmann, Daniel E., Picker, Louis J., Kappler, John W., Walker, Bruce D.

Volltext

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice von Rubtsov, Anatoly V., Rubtsova, Kira, Kappler, John W., Marrack, Philippa

Volltext

The Receptor Binding Domain of SARS-CoV-2 Lambda Variant Has a Better Chance Than the Delta Variant in Evading BNT162b2 COVID-19 mRNA Vaccine-Induced Humoral Immunity von Liu, Haolin, Wei, Pengcheng, Aviszus, Katja, Zhang, Qianqian, Linderberger, Jared, Yang, John, Liu, Junfeng, Chen, Zhongzhou, Waheed, Hassan, Reynoso, Lyndon, Downey, Gregory P, Frankel, Stephen K, Kappler, John W, Marrack, Philippa, Zhang, Gongyi

Volltext