Clinical use of current polygenic risk scores may exacerbate health disparities von Martin, Alicia R., Kanai, Masahiro, Kamatani, Yoichiro, Okada, Yukinori, Neale, Benjamin M., Daly, Mark J.

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Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set von Kanai, Masahiro, Tanaka, Toshihiro, Okada, Yukinori

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Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases von Kanai, Masahiro, Akiyama, Masato, Takahashi, Atsushi, Matoba, Nana, Momozawa, Yukihide, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Hirata, Makoto, Matsuda, Koichi, Kubo, Michiaki, Okada, Yukinori, Kamatani, Yoichiro

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Population-specific causal disease effect sizes in functionally important regions impacted by selection von Shi, Huwenbo, Gazal, Steven, Kanai, Masahiro, Koch, Evan M., Schoech, Armin P., Siewert, Katherine M., Kim, Samuel S., Luo, Yang, Amariuta, Tiffany, Huang, Hailiang, Okada, Yukinori, Raychaudhuri, Soumya, Sunyaev, Shamil R., Price, Alkes L.

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Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps von Adeyemo, Adebowale, Balaconis, Mary K, Darnes, Deanna R, Fatumo, Segun, Granados Moreno, Palmira, Hodonsky, Chani J, Inouye, Michael

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Genome-wide association study identifies 112 new loci for body mass index in the Japanese population von Akiyama, Masato, Okada, Yukinori, Kanai, Masahiro, Takahashi, Atsushi, Momozawa, Yukihide, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Hirata, Makoto, Matsuda, Koichi, Iwasaki, Motoki, Yamaji, Taiki, Sawada, Norie, Hachiya, Tsuyoshi, Tanno, Kozo, Shimizu, Atsushi, Hozawa, Atsushi, Minegishi, Naoko, Tsugane, Shoichiro, Yamamoto, Masayuki, Kubo, Michiaki, Kamatani, Yoichiro

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Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction von Sakaue, Saori, Hirata, Jun, Kanai, Masahiro, Suzuki, Ken, Akiyama, Masato, Lai Too, Chun, Arayssi, Thurayya, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad W., Saxena, Richa, Padyukov, Leonid, Hirata, Makoto, Matsuda, Koichi, Murakami, Yoshinori, Kamatani, Yoichiro, Okada, Yukinori

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Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan von Sakaue, Saori, Kanai, Masahiro, Karjalainen, Juha, Akiyama, Masato, Kurki, Mitja, Matoba, Nana, Takahashi, Atsushi, Hirata, Makoto, Kubo, Michiaki, Matsuda, Koichi, Murakami, Yoshinori, Daly, Mark J., Kamatani, Yoichiro, Okada, Yukinori

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Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power von Atkinson, Elizabeth G., Maihofer, Adam X., Kanai, Masahiro, Martin, Alicia R., Karczewski, Konrad J., Santoro, Marcos L., Ulirsch, Jacob C., Kamatani, Yoichiro, Okada, Yukinori, Finucane, Hilary K., Koenen, Karestan C., Nievergelt, Caroline M., Daly, Mark J., Neale, Benjamin M.

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Realization of the Open-Boundary Totally Asymmetric Simple Exclusion Process on a Ring von Kanai, Masahiro

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Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese von Okada, Yukinori, Momozawa, Yukihide, Ashikawa, Kyota, Kanai, Masahiro, Matsuda, Koichi, Kamatani, Yoichiro, Takahashi, Atsushi, Kubo, Michiaki

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Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese von Okada, Yukinori, Momozawa, Yukihide, Sakaue, Saori, Kanai, Masahiro, Ishigaki, Kazuyoshi, Akiyama, Masato, Kishikawa, Toshihiro, Arai, Yasumichi, Sasaki, Takashi, Kosaki, Kenjiro, Suematsu, Makoto, Matsuda, Koichi, Yamamoto, Kazuhiko, Kubo, Michiaki, Hirose, Nobuyoshi, Kamatani, Yoichiro

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Genome-wide functional screen of 3′UTR variants uncovers causal variants for human disease and evolution von Griesemer, Dustin, Xue, James R., Reilly, Steven K., Ulirsch, Jacob C., Kukreja, Kalki, Davis, Joe R., Kanai, Masahiro, Yang, David K., Butts, John C., Guney, Mehmet H., Luban, Jeremy, Montgomery, Stephen B., Finucane, Hilary K., Novina, Carl D., Tewhey, Ryan, Sabeti, Pardis C.

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Grimon: graphical interface to visualize multi-omics networks von Kanai, Masahiro, Maeda, Yuichi, Okada, Yukinori

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Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population von Suzuki, Ken, Akiyama, Masato, Ishigaki, Kazuyoshi, Kanai, Masahiro, Hosoe, Jun, Shojima, Nobuhiro, Hozawa, Atsushi, Kadota, Aya, Kuriki, Kiyonori, Naito, Mariko, Tanno, Kozo, Ishigaki, Yasushi, Hirata, Makoto, Matsuda, Koichi, Iwata, Nakao, Ikeda, Masashi, Sawada, Norie, Yamaji, Taiki, Iwasaki, Motoki, Ikegawa, Shiro, Maeda, Shiro, Murakami, Yoshinori, Wakai, Kenji, Tsugane, Shoichiro, Sasaki, Makoto, Yamamoto, Masayuki, Okada, Yukinori, Kubo, Michiaki, Kamatani, Yoichiro, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi

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Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores von Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J., Khera, Amit V., Okada, Yukinori, Martin, Alicia R., Finucane, Hilary K., Price, Alkes L.

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Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features von Ray, John P., de Boer, Carl G., Fulco, Charles P., Lareau, Caleb A., Kanai, Masahiro, Ulirsch, Jacob C., Tewhey, Ryan, Ludwig, Leif S., Reilly, Steven K., Bergman, Drew T., Engreitz, Jesse M., Issner, Robbyn, Finucane, Hilary K., Lander, Eric S., Regev, Aviv, Hacohen, Nir

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Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population von Hirata, Jun, Hosomichi, Kazuyoshi, Sakaue, Saori, Kanai, Masahiro, Nakaoka, Hirofumi, Ishigaki, Kazuyoshi, Suzuki, Ken, Akiyama, Masato, Kishikawa, Toshihiro, Ogawa, Kotaro, Masuda, Tatsuo, Yamamoto, Kenichi, Hirata, Makoto, Matsuda, Koichi, Momozawa, Yukihide, Inoue, Ituro, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori

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Leveraging fine-scale population structures for precision healthcare von Kanai, Masahiro

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Challenges and Opportunities for Developing More Generalizable Polygenic Risk Scores von Wang, Ying, Tsuo, Kristin, Kanai, Masahiro, Neale, Benjamin M, Martin, Alicia R

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