Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA von Zelensky, Alex N., Schimmel, Joost, Kool, Hanneke, Kanaar, Roland, Tijsterman, Marcel

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DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage von Reuvers, Thom G. A., Kanaar, Roland, Nonnekens, Julie

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Genome editing by natural and engineered CRISPR-associated nucleases von Wu, Wen Y., Lebbink, Joyce H. G., Kanaar, Roland, Geijsen, Niels, van der Oost, John

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DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation von van de Kamp, Gerarda, Heemskerk, Tim, Kanaar, Roland, Essers, Jeroen

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Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair von Paul, Maarten W., Sidhu, Arshdeep, Liang, Yongxin, Van Rossum-Fikkert, Sarah E., Odijk, Hanny, Zelensky, Alex N., Kanaar, Roland, Wyman, Claire

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Exploiting DNA repair defects for novel cancer therapies von van Gent, Dik C, Kanaar, Roland

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Mismatch repair and homeologous recombination von Tham, Khek-Chian, Kanaar, Roland, Lebbink, Joyce H.G.

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Regulation of DNA strand exchange in homologous recombination von Holthausen, J. Thomas, Wyman, Claire, Kanaar, Roland

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Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells von Roobol, Stefan J., van den Bent, Irene, van Cappellen, Wiggert A., Abraham, Tsion E., Paul, Maarten W., Kanaar, Roland, Houtsmuller, Adriaan B., van Gent, Dik C., Essers, Jeroen

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BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination von Ghouil, Rania, Miron, Simona, Koornneef, Lieke, Veerman, Jasper, Paul, Maarten W., Le Du, Marie-Hélène, Sleddens-Linkels, Esther, van Rossum-Fikkert, Sari E., van Loon, Yvette, Felipe-Medina, Natalia, Pendas, Alberto M., Maas, Alex, Essers, Jeroen, Legrand, Pierre, Baarends, Willy M., Kanaar, Roland, Zinn-Justin, Sophie, Zelensky, Alex N.

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Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment von Naipal, Kishan A T, Verkaik, Nicole S, Ameziane, Najim, van Deurzen, Carolien H M, Ter Brugge, Petra, Meijers, Matty, Sieuwerts, Anieta M, Martens, John W, O'Connor, Mark J, Vrieling, Harry, Hoeijmakers, Jan H J, Jonkers, Jos, Kanaar, Roland, de Winter, Johan P, Vreeswijk, Maaike P, Jager, Agnes, van Gent, Dik C

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Tumor slice culture system to assess drug response of primary breast cancer von Naipal, Kishan A T, Verkaik, Nicole S, Sánchez, Humberto, van Deurzen, Carolien H M, den Bakker, Michael A, Hoeijmakers, Jan H J, Kanaar, Roland, Vreeswijk, Maaike P G, Jager, Agnes, van Gent, Dik C

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Synergistic Roles of Non-Homologous End Joining and Homologous Recombination in Repair of Ionizing Radiation-Induced DNA Double Strand Breaks in Mouse Embryonic Stem Cells von van de Kamp, Gerarda, Heemskerk, Tim, Kanaar, Roland, Essers, Jeroen

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Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation von van der Pluijm, Ingrid, Burger, Joyce, van Heijningen, Paula M, IJpma, Arne, van Vliet, Nicole, Milanese, Chiara, Schoonderwoerd, Kees, Sluiter, Willem, Ringuette, Lea-Jeanne, Dekkers, Dirk H W, Que, Ivo, Kaijzel, Erik L, te Riet, Luuk, MacFarlane, Elena G, Das, Devashish, van der Linden, Reinier, Vermeij, Marcel, Demmers, Jeroen A, Mastroberardino, Pier G, Davis, Elaine C, Yanagisawa, Hiromi, Dietz, Harry C, Kanaar, Roland, Essers, Jeroen

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Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure von Muniesa-Vargas, Alba, Davó-Martínez, Carlota, Ribeiro-Silva, Cristina, van der Woude, Melanie, Thijssen, Karen L., Haspels, Ben, Häckes, David, Kaynak, Ülkem U., Kanaar, Roland, Marteijn, Jurgen A., Theil, Arjan F., Kuijten, Maayke M. P., Vermeulen, Wim, Lans, Hannes

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Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair von Muñoz, Ivan M., Hain, Karolina, Déclais, Anne-Cécile, Gardiner, Mary, Toh, Geraldine W., Sanchez-Pulido, Luis, Heuckmann, Johannes M., Toth, Rachel, Macartney, Thomas, Eppink, Berina, Kanaar, Roland, Ponting, Chris P., Lilley, David M.J., Rouse, John

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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition von Krawczyk, Przemek M, Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J, Buist, Marrije R, Soullié, Thomas, Rens, Joost, Verhagen, Hence J.M, O'Connor, Mark J, Franken, Nicolaas A.P, ten Hagen, Timo L.M, Kanaar, Roland, Aten, Jacob A

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Nuclear Dynamics of PCNA in DNA Replication and Repair von Essers, Jeroen, Theil, Arjan F., Baldeyron, Céline, van Cappellen, Wiggert A., Houtsmuller, Adriaan B., Kanaar, Roland, Vermeulen, Wim

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The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair von Mardenborough, Yannicka S N, Nitsenko, Katerina, Laffeber, Charlie, Duboc, Camille, Sahin, Enes, Quessada-Vial, Audrey, Winterwerp, Herrie H K, Sixma, Titia K, Kanaar, Roland, Friedhoff, Peter, Strick, Terence R, Lebbink, Joyce H G

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The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination von van den Tempel, Nathalie, Laffeber, Charlie, Odijk, Hanny, van Cappellen, Wiggert A, van Rhoon, Gerard C, Franckena, Martine, Kanaar, Roland

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