Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates von Kamath, Amrita V., Iyer, Suhasini

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Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies von Kamath, Amrita V.

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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity von Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα) von Dragovich, Peter S., Adhikari, Pragya, Blake, Robert A., Blaquiere, Nicole, Chen, Jinhua, Cheng, Yun-Xing, den Besten, Willem, Han, Jinping, Hartman, Steven J., He, Jintang, He, Mingtao, Rei Ingalla, Ellen, Kamath, Amrita V., Kleinheinz, Tracy, Lai, Tommy, Leipold, Douglas D., Li, Chun Sing, Liu, Qi, Lu, Jiawei, Lu, Ying, Meng, Fanwei, Meng, Lingyao, Ng, Carl, Peng, Kaishan, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sadowsky, Jack D., Sampath, Deepak, Staben, Leanna, Staben, Steven T., Wai, John, Wan, Kunpeng, Wang, Xinxin, Wei, BinQing, Wertz, Ingrid E., Xin, Jianfeng, Xu, Keyang, Yao, Hui, Zang, Richard, Zhang, Donglu, Zhou, Hao, Zhao, Yongxin

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Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging von Zhou, Chenguang, Cai, Hao, Baruch, Amos, Lewin-Koh, Nicholas, Yang, Meng, Guo, Fengxun, Xu, Deming, Deng, Rong, Hazenbos, Wouter, Kamath, Amrita V

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Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper von Ménochet, Karelle, Yu, Hongbin, Wang, Bonnie, Tibbitts, Jay, Hsu, Cheng-Pang, Kamath, Amrita V., Richter, Wolfgang F., Baumann, Andreas

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Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma von Cai, Hao, Kakiuchi-Kiyota, Satoko, Hendricks, Robert, Zhong, Shelly, Liu, Luna, Adedeji, Adeyemi O., Chan, Pamela, Schutten, Melissa M., Kamath, Amrita V., Ovacik, Meric A.

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A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice von Wang, Hongzhi, Li, Ran, Sadekar, Shraddha, Kamath, Amrita V., Shen, Ben-Quan

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Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats von Cai, Hao, Yip, Victor, Lee, M. Violet, Wong, Sylvia, Saad, Ola, Ma, Shuguang, Ljumanovic, Nina, Khojasteh, S. Cyrus, Kamath, Amrita, Shen, Ben-Quan

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Challenges and advances in the assessment of the disposition of antibody-drug conjugates von Kamath, Amrita V., Iyer, Suhasini

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Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics von Rafidi, Hanine, Estevez, Alberto, Ferl, Gregory Z., Mandikian, Danielle, Stainton, Shannon, Sermeno, Lauren, Williams, Simon P., Kamath, Amrita, Koerber, James T., Boswell, C. Andrew

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A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antib... von Peck, Melicent, Rothenberg, Michael E, Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V, Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S, Leonardelli, Marisa, Tavel, Jorge A

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Calicheamicin Antibody-Drug Conjugates with Improved Properties von Vollmar, Breanna S., Frantz, Chris, Schutten, Melissa M., Zhong, Fiona, Rosario, Geoffrey del, Go, Mary Ann T., Yu, Shang-Fan, Leipold, Douglas D., Kamath, Amrita, Ng, Carl, Xu, Keyang, Cruz-Chuh, Josefa Dela, Kozak, Katherine R., Chen, Jinhua, Xu, Zijin, Wai, John, Adhikari, Pragya, Erickson, Hans K., Dragovich, Peter S., Polson, Andrew G., Pillow, Thomas H.

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics von Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita, Crowell, Susan R.

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Tensions in teaching senior biology using inquiry based learning von Kamath, Amrita, White, Peta J

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Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration von Ramos, Madeleine K., Mandikian, Danielle, Sermeno, Lauren N., King, Anna, Dent, Alecia T., Ho, Jason, Ulufatu, Sheila, Lombana, T. Noelle, Spiess, Christoph, Go, Mary Ann T., Yu, Shang-Fan, Kamath, Amrita, Ferl, Gregory Z., Boswell, C. Andrew

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Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies von Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew

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Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules von Crowell, Susan R, Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M, Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V, Kelley, Robert F

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Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus von Deng, Rong, Zhou, Chenguang, Li, Dongwei, Cai, Hao, Sukumaran, Siddharth, Carrasco-Triguero, Montserrat, Saad, Ola, Nazzal, Denise, Lowe, Christopher, Ramanujan, Saroja, Kamath, Amrita V

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A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK von Li, Ran, Dere, Edward, Kwong, Mandy, Fei, Mingjian, Dave, Rutwij, Masih, Shabkhaiz, Wang, Joy, McNamara, Erin, Huang, Haochu, Liang, Wei-Ching, Schutt, Leah, Kamath, Amrita V., Ovacik, Meric A.

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