Mild and General Methods for the Palladium-Catalyzed Cyanation of Aryl and Heteroaryl Chlorides von Littke, Adam, Soumeillant, Maxime, Kaltenbach, Robert F, Cherney, Robert J, Tarby, Christine M, Kiau, Susanne

Volltext

Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series von Tarby, Christine M., Kaltenbach, Robert F., Huynh, Tram, Pudzianowski, Andrew, Shen, Henry, Ortega-Nanos, Marie, Sheriff, Steven, Newitt, John A., McDonnell, Patricia A., Burford, Neil, Fairchild, Craig R., Vaccaro, Wayne, Chen, Zhong, Borzilleri, Robert M., Naglich, Joseph, Lombardo, Louis J., Gottardis, Marco, Trainor, George L., Roussell, Deborah L.

Volltext

Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases von Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P

Volltext

Identification of selective inhibitors of cyclin dependent kinase 4 von Carini, David J, Kaltenbach, Robert F, Liu, Jie, Benfield, Pamela A, Boylan, John, Boisclair, Michael, Brizuela, Leonardo, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert, Harrison, Barbara A, Harrison, Kimberly, Akamike, Emeka, Markwalder, Jay A, Nakano, Yuki, Seitz, Steven P, Sharp, Diane M, Trainor, George L, Sielecki, Thais M

Volltext

Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors von Kaltenbach, Robert F, Patel, Mona, Waltermire, Robert E, Harris, Gregory D, Stone, Benjamin R.P, Klabe, Ronald M, Garber, Sena, Bacheler, Lee T, Cordova, Beverly C, Logue, Kelly, Wright, Matthew R, Erickson-Viitanen, Susan, Trainor, George L

Volltext

DPC 681 and DPC 684: Potent, Selective Inhibitors of Human Immunodeficiency Virus Protease Active against Clinically Relevant Mutant Variants von KALTENBACH, Robert F, TRAINOR, George, KLABE, Ronald, DIAMOND, Sharon, DAVIES, Marc, SAYE, Joanne, JONA, Ianan, ERICKSON-VIITANEN, Susan, GETMAN, Daniel, HARRIS, Greg, GARBER, Sena, CORDOVA, Beverly, BACHELER, Lee, JEFFREY, Susan, LOGUE, Kelly, CAWOOD, Pamela

Volltext

Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors von Nugiel, David A, Jacobs, Kim, Worley, Tabitha, Patel, Mona, Kaltenbach, Robert F, Meyer, Dayton T, Jadhav, Prabhakar K, De Lucca, George V, Smyser, Thomas E, Klabe, Ronald M, Bacheler, Lee T, Rayner, Marlene M, Seitz, Steven P

Volltext

Stereoisomers of Cyclic Urea HIV-1 Protease Inhibitors:  Synthesis and Binding Affinities von Kaltenbach, Robert F, Nugiel, David A, Lam, Patrick Y. S, Klabe, Ronald M, Seitz, Steven P

Volltext

Calculated and Experimental Low-Energy Conformations of Cyclic Urea HIV Protease Inhibitors von Hodge, C. Nicholas, Lam, Patrick Y. S, Eyermann, Charles J, Jadhav, Prabhakar K, Ru, Y, Fernandez, Christina H, De Lucca, George V, Chang, Chong-Hwan, Kaltenbach, Robert F, Holler, Edward R, Woerner, Francis, Daneker, Wayne F, Emmett, George, Calabrese, Joseph C, Aldrich, Paul E

Volltext

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases von Cheng, Peter T. W, Zhang, Hao, Shi, Jun, Tao, Shiwei, Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Shi, Yan, Wang, Ying, Dhanusu, Suresh, Reddigunta, Ramesh, Kumaravel, Selvakumar, Jusuf, Sutjano, Smith, Daniel, Krishnananthan, Subramaniam, Li, Jianqing, Wang, Tao, Heiry, Rebekah, Sum, Chi Shing, Kalinowski, Stephen S, Hung, Chen-Pin, Chu, Ching-Hsuen, Azzara, Anthony V, Ziegler, Milinda, Burns, Lisa, Zinker, Bradley A, Boehm, Stephanie, Taylor, Joseph, Sapuppo, Julia, Mosure, Kathy, Everlof, Gerry, Guarino, Victor, Zhang, Lisa, Yang, Yanou, Ruan, Qian, Xu, Carrie, Apedo, Atsu, Traeger, Sarah C, Cvijic, Mary Ellen, Lentz, Kimberley A, Tirucherai, Giridhar, Sivaraman, Lakshmi, Robl, Jeffrey, Ellsworth, Bruce A, Rosen, Glenn, Gordon, David A, Soars, Matthew G, Gill, Michael, Murphy, Brian J

Volltext

Phospholipase C Inhibitors: A New Class of Agents von Perrella, Frank W, Chen, Shih-Fong, Behrens, Davette L, Kaltenbach, Robert F. III, Seitz, Steven P

Volltext

Chiral synthetic macrodiolide and macrotriolide ionophores with C2- and C2symmetry von Burke, Steven D, Porter, Warren J, Rancourt, Jean, Kaltenbach, Robert F

Volltext

ISOXAZOLE O-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS von ZHANG, Hao, SHI, Yan, CHENG, Peter Tai Wah, KALTENBACH, Robert F., III, LI, Jun

Volltext bestellen

Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1′ substituents von Kaltenbach, Robert F., Klabe, Ronald M., Cordova, Beverly C., Seitz, Steven P.

Volltext

The synthesis of symmetrical and unsymmetrical P1/P1′ cyclic ureas as HIV protease inhibitors von Patel, Mona, Kaltenbach, Robert F., Nugiel, David A., McHugh, Robert J., Jadhav, Prabhakar K., Bacheler, Lee T., Cordova, Beverly C., Klabe, Ronald M., Erickson-Viitanen, Susan, Garber, Sena, Reid, Carol, Seitz, Steven P.

Volltext

Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases von Markwalder, Jay A., Arnone, Marc R., Benfield, Pamela A., Boisclair, Michael, Burton, Catherine R., Chang, Chong-Hwan, Cox, Sarah S., Czerniak, Philip M., Dean, Charity L., Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A., Kaltenbach, Robert F., Nugiel, David A., Rossi, Karen A., Sherk, Susan R., Sisk, Lisa M., Stouten, Pieter, Trainor, George L., Worland, Peter, Seitz, Steven P.

Volltext

ISOXAZOLE O-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS von ZHANG, Hao, SHI, Yan, CHENG, Peter Tai Wah, KALTENBACH, Robert F., III, LI, Jun

Volltext bestellen

ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS von ZHANG, Hao, SHI, Yan, CHENG, Peter Tai Wah, WANG, Ying, KALTENBACH, Robert F. III

Volltext bestellen

CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS von CHENG, Peter, Tai, Wah, ZHANG, Hao, WALKER, Steven J, DHANUSU, Suresh, LI, Jun, CORTE, James R, SELVAKUMAR, Kumaravel, REDDIGUNTA, Ramesh Babu, SHI, Yan, SHI, Jun, KENNEDY, Lawrence J, KALTENBACH, Robert, F., III, TAO, Shiwei, FANG, Tianan, JUSUF, Sutjano

Volltext bestellen

ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS von ZHANG, Hao, SHI, Yan, CHENG, Peter Tai Wah, WALKER, Steven J, KALTENBACH, III, Robert F, LI, Jun

Volltext bestellen