A potential therapeutic target for FLT3-ITD AML: PIM1 kinase von Fathi, Amir T, Arowojolu, Omotayo, Swinnen, Ian, Sato, Takashi, Rajkhowa, Trivikram, Small, Donald, Marmsater, Fredrik, Robinson, John E, Gross, Stefan David, Martinson, Matthew, Allen, Shelley, Kallan, Nicholas C, Levis, Mark

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Discovery and SAR of spirochromane Akt inhibitors von Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

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Discovery of pyrrolopyrimidine inhibitors of Akt von Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.

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Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate von Lane, Jonathan W, Spencer, Keith L, Shakya, Sagar R, Kallan, Nicholas C, Stengel, Peter J, Remarchuk, Travis

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors von Bencsik, Josef R., Xiao, Dengming, Blake, James F., Kallan, Nicholas C., Mitchell, Ian S., Spencer, Keith L., Xu, Rui, Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Woessner, Richard D., Dizon, Faith, Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J., Prior, Wei Wei, Murray, Lesley J.

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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors von Blake, James F, Xu, Rui, Bencsik, Josef R, Xiao, Dengming, Kallan, Nicholas C, Schlachter, Stephen, Mitchell, Ian S, Spencer, Keith L, Banka, Anna L, Wallace, Eli M, Gloor, Susan L, Martinson, Matthew, Woessner, Richard D, Vigers, Guy P.A, Brandhuber, Barbara J, Liang, Jun, Safina, Brian S, Li, Jun, Zhang, Birong, Chabot, Christine, Do, Steven, Lee, Leslie, Oeh, Jason, Sampath, Deepak, Lee, Brian B, Lin, Kui, Liederer, Bianca M, Skelton, Nicholas J

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Synthesis of the Ring System of Phomactin D Using a Suzuki Macrocyclization von Kallan, Nicholas C, Halcomb, Randall L

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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species von Hunt, Kevin W, Cook, Adam W, Watts, Ryan J, Clark, Christopher T, Vigers, Guy, Smith, Darin, Metcalf, Andrew T, Gunawardana, Indrani W, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Thomas, Allen A, Rana, Sumeet, Kallan, Nicholas C, DeLisle, Robert K, Rizzi, James P, Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P, Marlow, Allison, Liu, Xingrong, Tang, Tony P

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Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats von Takahashi, Ryan, Ma, Shuguang, Deese, Alan, Yue, Qin, Kim-Kang, Heasook, Yi, Yijun, Siu, Michael, Hunt, Kevin W, Kallan, Nicholas C, Hop, Cornelis E C A, Liu, Xingrong, Khojasteh, S Cyrus

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Discovery of a Novel Class of Imidazo[1,2‑a]Pyridines with Potent PDGFR Activity and Oral Bioavailability von Hicken, Erik J, Marmsater, Fred P, Munson, Mark C, Schlachter, Stephen T, Robinson, John E, Allen, Shelley, Burgess, Laurence E, DeLisle, Robert Kirk, Rizzi, James P, Topalov, George T, Zhao, Qian, Hicks, Julie M, Kallan, Nicholas C, Tarlton, Eugene, Allen, Andrew, Callejo, Michele, Cox, April, Rana, Sumeet, Klopfenstein, Nathalie, Woessner, Richard, Lyssikatos, Joseph P

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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA von Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

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Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp von Takahashi, Ryan, Ma, Shuguang, Yue, Qin, Kim-Kang, Heasook, Yi, Yijun, Lyssikatos, Joseph P., Regal, Kelly, Hunt, Kevin W., Kallan, Nicholas C., Siu, Michael, Hop, Cornelis E. C. A., Liu, Xingrong, Khojasteh, S. Cyrus

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TEMPO Synthesis, Characterization and Catalysis: An Integrated Upper-Division Laboratory von Mahapatro, Surendra N., Kallan, Nicholas C., Hovey, Tanden A., De Dios, Robyn Krystal, Vergil, Catherine, Lai, Trinh, De Dios, Robert Christian, Tran, Danny, McEvoy, James P.

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HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS von Leivers, Anna L, Bencsik, Josef R, Blake, James F, Safina, Brian, Schlachter, Stephen T, Chabot, Christine, Kallan, Nicholas C, Xu, Rui, Liang, Jun, Do, Steven, Xiao, Dengming, Zhang, Birong, Mitchell, Ian S, Spencer, Keith Lee, Wallace, Eli M

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HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS von Leivers, Anna L, Bencsik, Josef R, Blake, James F, Safina, Brian, Schlachter, Stephen T, Chabot, Christine, Kallan, Nicholas C, Xu, Rui, Liang, Jun, Do, Steven, Xiao, Dengming, Zhang, Birong, Mitchell, Ian S, Spencer, Keith Lee, Wallace, Eli M

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بيريميديل هيدروكسي السيكلوبنتان كمثبط للبروتين كيناز akt von KALLAN, NICHOLAS, C, CHABOT, CHRISTINE, BENCSIK, JOSEF, ZHANG, BIRONG, MITCHELL, IAN, S, DO, STEVEN, BLAKE, JAMES, F, SPENCER, KEITH, L, LIANG, JUN, XU, RU, SAFINA, BRIAN, XIAO, DENGMING

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Determination of the Effects of a Bipolar Polypyridylosmium(II) Complex on the Stability of Montmorillonite Colloids von Franklin, Elena S., Kallan, Nicholas C., Mahoney, Joseph M., Blauch, David N.

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كيكلو بينتان البيريميديل كمثبطات البروتين كيناز akt von KALLAN, NICHOLAS, C, BENCSIK, JOSEF, SCHLACHTER, STEPHEN, T, XU, RUI, WELCH, MIKE, MITCHELL, IAN, S, SAFINA, BRIAN, S, GRAHAM, JAMES, M, BLAKE, JAMES, F, SPENCER, KEITH, L, LIANG, JUN, XIAO, DENGMING

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CYCLOPENTA [D] PYRIMIDINES UTILES EN TANT QU'INHIBITEURS DE LA PROTEINE KINASE AKT von CHABOT, CHRISTINE, BLAKE, JAMES F, SPENCER, KEITH LEE, LIANG, JUN, XIAO, DENGMING, BENCSIK, JOSEF R, XU, RUI, SCHLACHTER, STEPHEN, T, KALLAN, NICHOLAS C, MITCHELL, IAN S, BANKA, ANNA, L, WALLACE, ELI, M, SAFINA, BRIAN, LI, JUN

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HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS von Leivers, Anna L, Bencsik, Josef R, Blake, James F, Safina, Brian, Schlachter, Stephen T, Chabot, Christine, Kallan, Nicholas C, Xu, Rui, Liang, Jun, Do, Steven, Xiao, Dengming, Zhang, Birong, Mitchell, Ian S, Spencer, Keith Lee, Wallace, Eli M

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