Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast von Varma, MV, Kimoto, E, Scialis, R, Bi, Y, Lin, J, Eng, H, Kalgutkar, AS, El‐Kattan, AF, Rodrigues, AD, Tremaine, LM

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Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors von Kalgutkar, Amit S, Marnett, Alan B, Crews, Brenda C, Remmel, Rory P, Marnett, Lawrence J

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Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B:  SAR Studies on MAO Substrates and Inhibitors von Kalgutkar, Amit S, Dalvie, Deepak K, Castagnoli, Neal, Taylor, Timothy J

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Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2 von Kalgutkar, Amit S., Crews, Brenda C., Rowlinson, Scott W., Garner, Carlos, Seibert, Karen, Marnett, Lawrence J.

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A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385 von Rowlinson, Scott W., Kiefer, James R., Prusakiewicz, Jeffery J., Pawlitz, Jennifer L., Kozak, Kevin R., Kalgutkar, Amit S., Stallings, William C., Kurumbail, Ravi G., Marnett, Lawrence J.

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A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammon... von Soglia, John R, Contillo, Leonard G, Kalgutkar, Amit S, Zhao, Sabrina, Hop, Cornelis E. C. A, Boyd, James G, Cole, Mark J

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Cyclooxygenase 2 inhibitors: discovery, selectivity and the future von Marnett, Lawrence J., Kalgutkar, Amit S.

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Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition von Marnett, L J, Rowlinson, S W, Goodwin, D C, Kalgutkar, A S, Lanzo, C A

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Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors von Kalgutkar, Amit S., Crews, Brenda C., Rowlinson, Scott W., Marnett, Alan B., Kozak, Kevin R., Remmel, Rory P., Marnett, Lawrence J.

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Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators von Kalgutkar, Amit S, Kozak, Kevin R, Crews, Brenda C, Hochgesang, G. Phillip, Marnett, Lawrence J

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Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates von Kalgutkar, Amit S, Dalvie, Deepak

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Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisom... von Frederick, K.S., Maurer, T.S., Kalgutkar, A.S., Royer, L.J., Francone, O.L., Winter, S.M., Terra, S.G., Chen, D., Gao, X.

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Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents von Marnett, Lawrence J, Kalgutkar, Amit S

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Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species von Kalgutkar, A. S., Choo, E., Taylor, T. J., Marfat, A.

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Selective inhibitors of monoamine oxidase (MAO-A and MAO-B) as probes of its catalytic site and mechanism von Kalgutkar, Amit S., Castagnoli Jr, Neal, Testa, Bernard

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Design, Synthesis, and Biochemical Evaluation of N-Substituted Maleimides as Inhibitors of Prostaglandin Endoperoxide Synthases von Kalgutkar, Amit S, Crews, Brenda C, Marnett, Lawrence J

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Selective cyclooxygenase-2 inhibitors as non-ulcerogenic anti-inflammatory agents von Kalgutkar, Amit S

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4 von Kalgutkar, Amit S., Henne, Kirk R., Lame, Mary E., Vaz, Alfin D.N., Collin, Claire, Soglia, John R., Zhao, Sabrina X., Hop, Cornelis E.C.A.

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Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors von Kalgutkar, Amit S, Castagnoli, Neal

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Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity? von Kalgutkar, Amit S., Didiuk, Mary T.

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