Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) von Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K

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Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV von Feng, Jun, Zhang, Zhiyuan, Wallace, Michael B, Stafford, Jeffrey A, Kaldor, Stephen W, Kassel, Daniel B, Navre, Marc, Shi, Lihong, Skene, Robert J, Asakawa, Tomoko, Takeuchi, Koji, Xu, Rongda, Webb, David R, Gwaltney, Stephen L

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Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV von Zhang, Zhiyuan, Wallace, Michael B, Feng, Jun, Stafford, Jeffrey A, Skene, Robert J, Shi, Lihong, Lee, Bumsup, Aertgeerts, Kathleen, Jennings, Andy, Xu, Rongda, Kassel, Daniel B, Kaldor, Stephen W, Navre, Marc, Webb, David R, Gwaltney, Stephen L

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations von Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition von Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV von Feng, Jun, Zhang, Zhiyuan, Wallace, Michael B, Stafford, Jeffrey A, Kaldor, Stephen W, Kassel, Daniel B, Navre, Marc, Shi, Lihong, Skene, Robert J, Asakawa, Tomoko, Takeuchi, Koji, Xu, Rongda, Webb, David R, Gwaltney, Stephen L

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Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors von Bennett, Michael J., Wu, Yiqin, Boloor, Amogh, Matuszkiewicz, Jennifer, O'Connell, Shawn M., Shi, Lihong, Stansfield, Ryan K., Del Rosario, Joselyn R., Veal, James M., Hosfield, David J., Xu, Jiangchun, Kaldor, Stephen W., Stafford, Jeffrey A., Betancort, Juan M.

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Total synthesis of the macrolide antibiotic cytovaricin von Evans, David A, Kaldor, Stephen W, Jones, Todd K, Clardy, Jon, Stout, Thomas J

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Viracept (Nelfinavir Mesylate, AG1343):  A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease von Kaldor, Stephen W, Kalish, Vincent J, Davies, Jay F, Shetty, Bhasker V, Fritz, James E, Appelt, Krzysztof, Burgess, Jeffrey A, Campanale, Kristina M, Chirgadze, Nickolay Y, Clawson, David K, Dressman, Bruce A, Hatch, Steven D, Khalil, Deborah A, Kosa, Maha B, Lubbehusen, Penny P, Muesing, Mark A, Patick, Amy K, Reich, Siegfried H, Su, Kenneth S, Tatlock, John H

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Azetidinones as vasopressin V1a antagonists von Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D.G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.

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Combinatorial chemistry using polymer-supported reagents von Kaldor, Stephen W, Siegel, Miles G

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Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization / cleavage step von Dressman, Bruce A., Spangle, Larry A., Kaldor, Stephen W.

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Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries von Kaldor, Stephen W., Siegel, Miles G., Fritz, James E., Dressman, Bruce A., Hahn, Patric J.

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5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs von Johnson, Kirk W, Schaus, John M, Durkin, Margaret M, Audia, James E, Kaldor, Stephen W, Flaugh, Michael E, Adham, Nika, Zgombick, John M, Cohen, Marlene L, Branchek, Theresa A, Phebus, Lee A

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Assignment of stereochemistry in the oligomycin/rutamycin/cytovaricin family of antibiotics. Asymmetric synthesis of the rutamycin spiroketal synthon von Evans, David A, Rieger, Dale L, Jones, Todd K, Kaldor, Stephen W

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Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers von Kaldor, Stephen W, Fritz, James E, Tang, Joseph, McKinney, Emma R

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Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker von Dressman, Bruce A, Singh, Upinder, Kaldor, Stephen W

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N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide:  A Potent, Selective, and Orally Active 5-HT1F Receptor Agonist Potentially Useful for Migraine Therapy von Xu, Yao-Chang, Johnson, Kirk W, Phebus, Lee A, Cohen, Marlene, Nelson, David L, Schenck, Kathy, Walker, Clint D, Fritz, James E, Kaldor, Stephen W, LeTourneau, Michael E, Murff, Robert E, Zgombick, John M, Calligaro, David O, Audia, James E, Schaus, John M

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Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent von Fritz, James E., Hipskind, Philip A., Lobb, Karen L., Nixon, James A., Threlkeld, Penny G., Gitter, Bruce D., McMillian, Carl L., Kaldor, Stephen W.

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The synthesis of ethanolamine libraries from olefin scaffolds von Organ, Michael G, Kaldor, Stephen W, Dixon, Craig E, Parks, Daniel J, Singh, Upinder, Lavorato, David J, Isbester, Paul K, Siegel, Miles G

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