Structure–activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201 von Hayakawa, Nobuhiko, Noguchi, Masatsugu, Takeshita, Sen, Eviryanti, Agung, Seki, Yukie, Nishio, Hikaru, Yokoyama, Ryohei, Noguchi, Misato, Shuto, Manami, Shima, Yoichiro, Kuribayashi, Kanna, Kageyama, Shunsuke, Eda, Hiroyuki, Suzuki, Manabu, Hatta, Tomohisa, Iemura, Shun-ichiro, Natsume, Tohru, Tanabe, Itsuya, Nakagawa, Ryusuke, Shiozaki, Makoto, Sakurai, Kuniya, Shoji, Masataka, Andou, Ayatoshi, Yamamoto, Takashi

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Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis von Maruyama, Masafumi, Kobayashi, Motohiro, Sakai, Yasuhiro, Hiraoka, Nobuyoshi, Ohya, Ayumi, Kageyama, Shunsuke, Tanaka, Eiji, Nakayama, Jun, Morohoshi, Toshio

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Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis von Kageyama, Shunsuke, Matsushita, Junko, Yamamoto, Hiroshi

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Tu1864 A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages von Andou, Ayatoshi, Yamamoto, Takashi, Agung, Eviryanti, Seki, Yukie, Nishio, Hikaru, Shuto, Manami, Noguchi, Misato, Shima, Yoichiro, Takeshita, Sen, Yokoyama, Ryohei, Hayakawa, Nobuhiko, Noguchi, Masatsugu, Kageyama, Shunsuke, Eda, Hiroyuki, Shiozaki, Makoto, Tanabe, Itsuya, Nakagawa, Ryusuke, Sakurai, Kuniya, Masataka, Shoji

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Pharmacokinetics and Pharmacodynamics of AJW200, a Humanized Monoclonal Antibody to von Willebrand Factor, in Monkeys von Kageyama, Shunsuke, Yamamoto, Hiroshi, Nakazawa, Harumi, Matsushita, Junko, Kouyama, Tetsuya, Gonsho, Akinori, Ikeda, Yasuo, Yoshimoto, Ryota

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Anti-Human von Willebrand Factor Monoclonal Antibody AJvW-2 Prevents Thrombus Deposition and Neointima Formation After Balloon Injury in Guinea Pigs von Kageyama, Shunsuke, Yamamoto, Hiroshi, Yoshimoto, Ryota

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Challenges and Opportunities in IBD Clinical Trial Design von Dubinsky, Marla C., Collins, Rory, Abreu, Maria T., Abreu, Maria T., Collins, Rory, Dubinsky, Marla C., Jairath, Vipul, Lewis, James D., Lindsay, James, Merad, Miriam, Ng, Siew, Panaccione, Remo, Panes, Julian, Sands, Bruce, Siegal, Corey A., Singh, Siddarth, Vermeire, Severine, Ahuja, Vineet, Allez, Matthieu, Ananthakrishnan, Ashwin, Bemelman, Willem, Braun, Jonathan, Colombel, Jean-Frederic, Danese, Silvio, D’Haens, Geert, D’Hoore, André, Dignass, Axel, Dotan, Iris, Gassul, Miguel Angel, Griffiths, Anne, Halfvarson, Jonas, Hanauer, Stephen, Kotze, Paulo, Koutroubakis, Ioannis, Loftus, Edward, Louis, Edouard, Magro, Fernando, Mantzaris, Gerassimos, Mary, Jean-Yves, McGovern, Dermot, Munkholm, Pia, O’Morain, Colm, Panis, Yves, Peyrin-Biroulet, Laurent, Prantera, Cosimo, Ran, Zhihua, Siegmund, Britta, Silverberg, Mark, Stange, Eduard, Targan, Stephan, Tysk, Curt, Travis, Simon, Vatn, Morton, Yamamoto-Furusho, Yesus, Aarts, Janske, Abhyankar, Brihad, Ahmad, Harris, Aranda, Richard, Arora, Vipin, Benjacoub, Jalil, Berg, Sofie, Besuyen, Robin, Bojic, Daniela, Carriero, Valerio, Cataldi, Fabio, D’Agay, Laurence, Delgado-Aros, Silvia, Giannasca, Paul, Goyal, Kavitha, Greinwald, Roland, Gropper, Savion, Kageyama, Shunsuke, Laoun, Raphaël, Levesque, Barrett, Lissoos, Trevor, Modesto, Irene, Mohrbacher, Ralf, Mueller, Ralph, Naegeli, April, Naik, Snehal, Nguyen, Deanne, Niezychowski, Wojciech, O’Brien, Caitriona, Odnoletkova, Irina, Oortwijn, Alessandra, Park, Kun K.T., Radziszewski, Waldemar, Salese, Leonardo, Spleiss, Johannes, Stancati, Andrea, Tatro, Amanda, Thompson, Jennifer, Hofmann, Robert, Zambrano, Javier, Zhou, Wen, Zigmont, Ellen

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Anti‐thrombotic effects and bleeding risk of AJvW‐2, a monoclonal antibody against human von Willebrand factor von Kageyama, Shunsuke, Yamamoto, Hiroshi, Nagano, Mitsuyo, Arisaka, Harumi, Kayahara, Takashi, Yoshimoto, Ryota

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Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice von Sugiura, Toshihiko, Kageyama, Shunsuke, Andou, Ayatoshi, Miyazawa, Tomoko, Ejima, Chieko, Nakayama, Akira, Dohi, Taeko, Eda, Hiroyuki

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GlcNAc6ST‐1‐mediated decoration of MAdCAM‐1 protein with L‐selectin ligand carbohydrates directs disease activity of ulcerative colitis von Kobayashi, Motohiro, Hoshino, Hitomi, Masumoto, Junya, Fukushima, Mana, Suzawa, Kenichi, Kageyama, Shunsuke, Suzuki, Manabu, Ohtani, Haruo, Fukuda, Minoru, Nakayama, Jun

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An Orally Available Alpha 4 (α4) Integrin Antagonist AJM300 Increases the Peripheral Lymphocyte Counts: The Relationship Between Pharmacokinetics/Pharmacodynamics (PK/PD) and Effic... von Sugiura, Toshihiko, Miyazawa, Tomoko, Nakayama, Akira, Kageyama, Shunsuke, Eda, Hiroyuki

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Lymphocyte recruitment via high endothelial venules in lymphoid stroma of Warthin’s tumour von Ohya, Ayumi, Kobayashi, Motohiro, Sakai, Yasuhiro, Kawashima, Hiroto, Kageyama, Shunsuke, Nakayama, Jun

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M1647 An Orally Active Alpha4 Integrin Antagonist AJM300 Prevents the Development of Experimental Colitis Induced By Adoptive Transfer of IL-10 Deficient CD4+ T Cells in Mice von Sugiura, Toshihiko, Kageyama, Shunsuke, Kuribayashi, Kanna, Suzuki, Manabu

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A novel, orally active alpha 4 integrin antagonist, AJM300 prevents the development of experimental colitis induced by adoptive transfer of IL-10 deficient CD4(+) T cells in mice von Sugiura, Toshihiko, Kageyama, Shunsuke, Andou, Ayatoshi, Miyazawa, Tomoko, Ejima, Chieko, Nakayama, Akira, Dohi, Taeko, Eda, Hiroyuki

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Anti-Human vWF Monoclonal Antibody, AJvW-2 Fab, Inhibits Repetitive Coronary Artery Thrombosis without Bleeding Time Prolongation in Dogs von Kageyama, Shunsuke, Yamamoto, Hiroshi, Nakazawa, Harumi, Yoshimoto, Ryota

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EXTERIOR WALL STRUCTURE von KAGEYAMA SHUNSUKE

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PHARMACEUTICAL COMPOSITION FOR TREATING ULCERATIVE COLITIS von KAGEYAMA, SHUNSUKE, GODA, YOSHIKI, SUGIURA, TOSHIHIKO

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Pharmaceutical composition for treating ulcerative colitis von Sugiura, Toshihiko, Goda, Yoshiki, Kageyama, Shunsuke

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CS3B-2-4 Target identification of novel orally active anti-inflammatory compound: Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) inhibitor von Ayatoshi Andou, Takashi Yamamoto, Eviryanti Agung, Yukie Seki, Hikaru Nishio, Sen Takeshita, Nobuhiko Hayakawa, Masatsugu Noguchi, Ryohei Yokoyama, Manami Shuto, Misato Noguchi, Yoichiro Shima, Tohru Natsume, Shunsuke Kageyama, Hiroyuki Eda, Makoto Shiozaki, Masataka Shoji

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Pharmaceutical composition for treating ulcerative colitis von Sugiura, Toshihiko, Goda, Yoshiki, Kageyama, Shunsuke

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