Properties of Small Molecules Affecting Insulin Receptor Function von Schlein, Morten, Ludvigsen, Svend, Olsen, Helle B, Andersen, Asser S, Danielsen, Gillian M, Kaarsholm, Niels C

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Engineering-enhanced Protein Secretory Expression in Yeast with Application to Insulin von Kjeldsen, Thomas, Ludvigsen, Svend, Diers, Ivan, Balschmidt, Per, Sørensen, Anders R., Kaarsholm, Niels C.

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Spectroscopic signatures of the T to R conformational transition in the insulin hexamer von Roy, M, Brader, M L, Lee, R W, Kaarsholm, N C, Hansen, J F, Dunn, M F

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Solution Structure of an Engineered Insulin Monomer at Neutral pH von Olsen, Helle B, Ludvigsen, Svend, Kaarsholm, Niels C

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Structural Effects of Protein Lipidation as Revealed by LysB29-myristoyl, des(B30) Insulin von Olsen, Helle B, Kaarsholm, Niels C

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A structural switch in a mutant insulin exposes key residues for receptor binding von Ludvigsen, S, Olsen, H B, Kaarsholm, N C

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Engineering stability of the insulin monomer fold with application to structure-activity relationships von KAARSHOLM, N. C, NORRIS, K, JØRGENSEN, R. J, MIKKELSEN, J, LUDVIGSEN, S, OLSEN, O. H, SØRENSEN, A. R, HAVELUND, S

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Ligand-induced conformation change in folate-binding protein von KAARSHOLM, N. C, KOLSTRUP, A.-M, DANIELSEN, S. E, HOLM, J, HANSEN, S. I

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Allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions von Choi, Wonjae E., Brader, Mark L., Aguilar, Valentin, Kaarsholm, Niels C., Dunn, Michael F.

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Mechanisms of Stabilization of the Insulin Hexamer through Allosteric Ligand Interactions von Rahuel-Clermont, Sophie, French, Cherie A, Kaarsholm, Niels C, Dunn, Michael F

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Characterization of the r-state insulin hexamer and its derivatives. The hexamer is stabilized by heterotropic ligand binding interactions von Brader, Mark L, Kaarsholm, Niels C, Lee, Robert W. K, Dunn, Michael F

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The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core von Soerensen, Poul, Winther, Jakob R, Kaarsholm, Niels C, Poulsen, Flemming M

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Ionization behavior of native and mutant insulins : pK perturbation of B13-Glu in aggregated species von KAARSHOLM, N. C, HAVELUND, S, HOUGAARD, P

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The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix von Olsen, H B, Ludvigsen, S, Kaarsholm, N C

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High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy von Ludvigsen, S, Roy, M, Thøgersen, H, Kaarsholm, N C

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Raman signatures of ligand binding and allosteric conformation change in hexameric insulin von Ferrari, Davide, Diers, James R., Bocian, David F., Kaarsholm, Niels C., Dunn, Michael F.

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Ligand-induced conformational change in the minimized insulin receptor von Schlein, Morten, Havelund, Svend, Kristensen, Claus, Dunn, Michael F., Kaarsholm, Niels C.

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Structural Asymmetry and Half-Site Reactivity in the T to R Allosteric Transition of the Insulin Hexamer von Brzovic, Peter S, Choi, Wonjae E, Borchardt, Dan, Kaarsholm, Niels C, Dunn, Michael F

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Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin von Kaarsholm, Niels C, Ko, Hui Chong, Dunn, Michael F

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The R-state proinsulin and insulin hexamers mimic the carbonic anhydrase active site von BRADER, M. LO, KAARSHILM, N. C, DUNN, M. F

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