Crosstalk between the coagulation and complement systems in sepsis von Lupu, Florea, Keshari, Ravi S, Lambris, John D, Mark Coggeshall, K

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Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways von Popescu, Narcis I., Silasi, Robert, Keshari, Ravi S., Girton, Alanson, Burgett, Tarea, Zeerleder, Sacha S., Gailani, David, Gruber, Andras, Lupu, Florea, Coggeshall, K. Mark

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 von Peng, Qisheng, Malhotra, Shikha, Torchia, James A, Kerr, William G, Coggeshall, K Mark, Humphrey, Mary Beth

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Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons von Keshari, Ravi Shankar, Popescu, Narcis Ioan, Silasi, Robert, Regmi, Girija, Lupu, Cristina, Simmons, Joe H., Ricardo, Alonso, Coggeshall, K. Mark, Lupu, Florea

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IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production von Maeda, Kenichiro, Mehta, Harshini, Drevets, Douglas A., Coggeshall, K. Mark

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Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2 von Langer, Marybeth, Girton, Alanson W, Popescu, Narcis I, Burgett, Tarea, Metcalf, Jordan P, Coggeshall, K Mark

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B Cell Antigen Receptor Endocytosis and Antigen Presentation to T Cells Require Vav and Dynamin von Malhotra, Shikha, Kovats, Susan, Zhang, Weiguo, Coggeshall, K. Mark

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Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus–prone B6.Sle1.Yaa animals von Maeda, Kenichiro, Malykhin, Alex, Teague-Weber, Brittany N., Sun, Xiao-Hong, Farris, A. Darise, Coggeshall, K. Mark

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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan von Wolf, Andrea J., Reyes, Christopher N., Liang, Wenbin, Becker, Courtney, Shimada, Kenichi, Wheeler, Matthew L., Cho, Hee Cheol, Popescu, Narcis I., Coggeshall, K. Mark, Arditi, Moshe, Underhill, David M.

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Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage Chemotaxis von Vedham, Vidya, Phee, Hyewon, Coggeshall, K. Mark

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Gram-Positive Bacteria Cell Wall Peptidoglycan Polymers Activate Human Dendritic Cells to Produce IL-23 and IL-1β and Promote TH17 Cell Differentiation von Turner, Sean, Raisley, Brent, Roach, Kimberly, Bajaña, Sandra, Munroe, Melissa E., James, Judith A., Coggeshall, K. Mark, Kovats, Susan

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Inflammatory Cytokine Response to Bacillus anthracis Peptidoglycan Requires Phagocytosis and Lysosomal Trafficking von Iyer, Janaki K, Khurana, Taruna, Langer, Marybeth, West, Christopher M, Ballard, Jimmy D, Metcalf, Jordan P, Merkel, Tod J, Coggeshall, K. Mark

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Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis von Keshari, Ravi Shankar, Silasi, Robert, Popescu, Narcis Ioan, Patel, Maulin Mukeshchandra, Chaaban, Hala, Lupu, Cristina, Coggeshall, K. Mark, Mollnes, Tom Eirik, DeMarco, Steven J., Lupu, Florea

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C3 Opsonization of Anthrax Bacterium and Peptidoglycan Supports Recognition and Activation of Neutrophils von Popescu, Narcis, Keshari, Ravi S., Cochran, Jackie, Coggeshall, K. Mark, Lupu, Florea

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Convergence of Signaling Pathways on the Activation of ERK in B Cells von Jacob, Anand, Cooney, Damon, Pradhan, Madhura, Coggeshall, K. Mark

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Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway von Langer, Marybeth, Malykhin, Alexander, Maeda, Kenichiro, Chakrabarty, Kaushik, Williamson, Kelly S, Feasley, Christa L, West, Christopher M, Metcalf, Jordan P, Coggeshall, K Mark

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IL-6 blocks a discrete early step in lymphopoiesis von Maeda, Kazuhiko, Baba, Yoshihiro, Nagai, Yoshinori, Miyazaki, Kozo, Malykhin, Alexander, Nakamura, Koji, Kincade, Paul W., Sakaguchi, Nobuo, Coggeshall, K. Mark

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Toxin Inhibition of Antimicrobial Factors Induced by Bacillus anthracis Peptidoglycan in Human Blood von Barua, Soumitra, Iyer, Janaki K, Larabee, Jason L, Raisley, Brent, Hughes, Molly A, Coggeshall, K Mark, Ballard, Jimmy D

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Human Lung Innate Immune Response to Bacillus anthracis Spore Infection von Chakrabarty, Kaushik, Wu, Wenxin, Booth, J. Leland, Duggan, Elizabeth S, Nagle, Nancy N, Coggeshall, K. Mark, Metcalf, Jordan P

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Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers von Iyer, Janaki K, Coggeshall, K Mark

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