Unsupervised Learning‐based Drug Repositioning for Alzheimer’s Disease Targeting Brain Cell Type Specific Genetic Subtypes von Mishra, Ankit Kumar, Sahelijo, Nathan J, Priyadarshi, Dhawal, Jun, Gyungah R

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Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages von Chung, Jaeyoon, Wang, Xulong, Maruyama, Toru, Ma, Yiyi, Zhang, Xiaoling, Mez, Jesse, Sherva, Richard, Takeyama, Haruko, Lunetta, Kathryn L., Farrer, Lindsay A., Jun, Gyungah R.

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Multivariate analysis of blood and brain transcriptome in Alzheimer’s reveals unique APOE ε4‐related immune pathways von Panitch, Rebecca, Hu, Junming, Farrer, Lindsay A., Jun, Gyungah R

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Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease von Panitch, Rebecca, Hu, Junming, Chung, Jaeyoon, Zhu, Congcong, Meng, Gaoyuan, Xia, Weiming, Bennett, David A., Lunetta, Kathryn L., Ikezu, Tsuneya, Au, Rhoda, Stein, Thor D., Farrer, Lindsay A., Jun, Gyungah R.

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Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype von Friedberg, Jacob S., Aytan, Nurgul, Cherry, Jonathan D., Xia, Weiming, Standring, Oliver J., Alvarez, Victor E., Nicks, Raymond, Svirsky, Sarah, Meng, Gaoyuan, Jun, Gyungah, Ryu, Hoon, Au, Rhoda, Stein, Thor D.

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Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease von Panitch, Rebecca, Hu, Junming, Xia, Weiming, Bennett, David A, Stein, Thor D, Farrer, Lindsay A, Jun, Gyungah R

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Comparison of methods for multivariate gene-based association tests for complex diseases using common variants von Chung, Jaeyoon, Jun, Gyungah R, Dupuis, Josée, Farrer, Lindsay A

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Whole‐genome sequencing study in Koreans identifies novel loci for Alzheimer's disease von Kang, Moonil, Farrell, John J., Zhu, Congcong, Park, Hyeonseul, Kang, Sarang, Seo, Eun Hyun, Choi, Kyu Yeong, Jun, Gyungah R., Won, Sungho, Gim, Jungsoo, Lee, Kun Ho, Farrer, Lindsay A.

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APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response von Panitch, Rebecca, Sahelijo, Nathan, Hu, Junming, Nho, Kwangsik, Bennett, David A., Lunetta, Kathryn L., Au, Rhoda, Stein, Thor D., Farrer, Lindsay A., Jun, Gyungah R.

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Optimal blood tau species for the detection of Alzheimer’s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study von Montoliu-Gaya, Laia, Alosco, Michael L., Yhang, Eukyung, Tripodis, Yorghos, Sconzo, Daniel, Ally, Madeline, Grötschel, Lana, Ashton, Nicholas J., Lantero-Rodriguez, Juan, Sauer, Mathias, Gomes, Bárbara, Nilsson, Johanna, Brinkmalm, Gunnar, Sugarman, Michael A., Aparicio, Hugo J., Martin, Brett, Palmisano, Joseph N., Steinberg, Eric G., Simkin, Irene, Turk, Katherine W., Budson, Andrew E., Au, Rhoda, Farrer, Lindsay, Jun, Gyungah R., Kowall, Neil W., Stern, Robert A., Goldstein, Lee E., Qiu, Wei Qiao, Mez, Jesse, Huber, Bertrand Russell, Alvarez, Victor E., McKee, Ann C., Zetterberg, Henrik, Gobom, Johan, Stein, Thor D., Blennow, Kaj

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Genome‐wide association and multi‐omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women von Chung, Jaeyoon, Das, Anjali, Sun, Xinyu, Sobreira, Débora R., Leung, Yuk Yee, Igartua, Catherine, Mozaffari, Sahar, Chou, Yi‐Fan, Thiagalingam, Sam, Mez, Jesse, Zhang, Xiaoling, Jun, Gyungah R., Stein, Thor D., Kunkle, Brian W., Martin, Eden R., Pericak‐Vance, Margaret A., Mayeux, Richard, Haines, Jonathan L., Schellenberg, Gerard D., Nobrega, Marcelo A., Lunetta, Kathryn L., Pinto, Jayant M., Wang, Li‐San, Ober, Carole, Farrer, Lindsay A.

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Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy von Morrison, Madeline S, Aparicio, Hugo J, Blennow, Kaj, Zetterberg, Henrik, Ashton, Nicholas J, Karikari, Thomas K, Tripodis, Yorghos, Martin, Brett, Palmisano, Joseph N, Sugarman, Michael A, Frank, Brandon, Steinberg, Eric G, Turk, Katherine W, Budson, Andrew E, Au, Rhoda, Goldstein, Lee E, Jun, Gyungah R, Kowall, Neil W, Killiany, Ronald, Qiu, Wei Qiao, Stern, Robert A, Mez, Jesse, McKee, Ann C, Stein, Thor D, Alosco, Michael L

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Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease von Jun, Gyungah R., You, Yang, Zhu, Congcong, Meng, Gaoyuan, Chung, Jaeyoon, Panitch, Rebecca, Hu, Junming, Xia, Weiming, Bennett, David A., Foroud, Tatiana M., Wang, Li‐San, Haines, Jonathan L., Mayeux, Richard, Pericak‐Vance, Margaret A., Schellenberg, Gerard D., Au, Rhoda, Lunetta, Kathryn L., Ikezu, Tsuneya, Stein, Thor D., Farrer, Lindsay A.

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Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles von Chung, Jaeyoon, Sahelijo, Nathan, Maruyama, Toru, Hu, Junming, Panitch, Rebecca, Xia, Weiming, Mez, Jesse, Stein, Thor D, Saykin, Andrew J, Takeyama, Haruko, Farrer, Lindsay A, Crane, Paul K, Nho, Kwangsik, Jun, Gyungah R

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Cytokine Levels in Human Vitreous in Proliferative Diabetic Retinopathy von Loporchio, Dean F, Tam, Emily K, Cho, Jane, Chung, Jaeyoon, Jun, Gyungah R, Xia, Weiming, Fiorello, Marissa G, Siegel, Nicole H, Ness, Steven, Stein, Thor D, Subramanian, Manju L

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Plasma p‐tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau von Frank, Brandon, Ally, Madeline, Brekke, Bailee, Zetterberg, Henrik, Blennow, Kaj, Sugarman, Michael A., Ashton, Nicholas J., Karikari, Thomas K., Tripodis, Yorghos, Martin, Brett, Palmisano, Joseph N., Steinberg, Eric G., Simkina, Irene, Turk, Katherine W., Budson, Andrew E., O'Connor, Maureen K., Au, Rhoda, Goldstein, Lee E., Jun, Gyungah R., Kowall, Neil W., Stein, Thor D., McKee, Ann C., Killiany, Ronald, Qiu, Wei Qiao, Stern, Robert A., Mez, Jesse, Alosco, Michael L.

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Domain specific cognitive functions predict neuropathological traits in the Framingham Heart Study von Li, Donghe, Ang, Ting Fang Alvin, Xia, Weiming, Farrer, Lindsay A., Mez, Jesse, Au, Rhoda, Stein, Thor D., Jun, Gyungah R

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Neurofilament light chain in the vitreous humor of the eye von Subramanian, Manju L, Vig, Viha, Chung, Jaeyoon, Fiorello, Marissa G, Xia, Weiming, Zetterberg, Henrik, Blennow, Kaj, Zetterberg, Madeleine, Shareef, Farah, Siegel, Nicole H, Ness, Steven, Jun, Gyungah R, Stein, Thor D

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Two novel loci, COBL and SLC10A2 , for Alzheimer's disease in African Americans von Mez, Jesse, Chung, Jaeyoon, Jun, Gyungah, Kriegel, Joshua, Bourlas, Alexandra P, Sherva, Richard, Logue, Mark W, Barnes, Lisa L, Bennett, David A, Buxbaum, Joseph D, Byrd, Goldie S, Crane, Paul K, Ertekin-Taner, Nilüfer, Evans, Denis, Fallin, M. Daniele, Foroud, Tatiana, Goate, Alison, Graff-Radford, Neill R, Hall, Kathleen S, Kamboh, M. Ilyas, Kukull, Walter A, Larson, Eric B, Manly, Jennifer J, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Schellenberg, Gerard D, Lunetta, Kathryn L, Farrer, Lindsay A

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4 Evaluating Plasma GFAP for the Detection of Alzheimer’s Disease Dementia von Ally, Madeline, Zetterberg, Henrik, Blennow, Kaj, Ashton, Nicholas J., Karikari, Thomas K., Aparicio, Hugo, Sugarman, Michael A., Frank, Brandon, Tripodis, Yorghos, McKee, Ann C., Stein, Thor D., Martin, Brett, Palmisano, Joseph N., Steinberg, Eric G., Simkina, Irene, Farrer, Lindsay, Jun, Gyungah, Turk, Katherine W., Budson, Andrew E., O’Connor, Maureen K., Au, Rhoda, Qiu, Wei Qiao, Goldstein, Lee E., Killiany, Ronald, Kowall, Neil W., Stern, Robert A., Mez, Jesse, Alosco, Michael L.

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