Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression von Polley, Eric, Kunkel, Mark, Evans, David, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Connelly, John, Harris, Erik, Fer, Nicole, Sonkin, Dmitriy, Kaur, Gurmeet, Monks, Anne, Malik, Shakun, Morris, Joel, Teicher, Beverly A

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ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants von O’Neill, Matthew J., Yang, Tao, Laudeman, Julie, Calandranis, Maria E., Harvey, M. Lorena, Solus, Joseph F., Roden, Dan M., Glazer, Andrew M.

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3D Models of the NCI60 Cell Lines for Screening Oncology Compounds von Selby, Mike, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Silvers, Thomas, Lawrence, Scott, Kinders, Robert, Parchment, Ralph, Teicher, Beverly A., Evans, David M.

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Abstract 15609: ParSE-seq: A Calibrated Multiplexed Assay for Clinical Interpretation of Putative Splice-Altering Variants von Oneill, Matthew J, Yang, Tao, Laudeman, Julie, Calandranis, Maria, Glazer, Andrew, Roden, Dan M

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MP-470543-002 FURTHER EVIDENCE THAT IKS INHIBITION IS NOT THE SOLE MECHANISM UNDERLYING PROLONGED REPOLARIZATION IN TYPE 1 LONG QT SYNDROME (LQT1): ROLE FOR TRANSCRIPTIONALLY UPREG... von Wada, Yuko, Laudeman, Julie A., Harvey, Margaret L., Solus, Joseph, Roden, Dan M.

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Abstract 1028: Combination screening of KRASG12C specific inhibitors with other targeted therapies in patient-derived multicellular tumor spheroids von Dexheimer, Thomas S., Silvers, Thomas, Delosh, René, Laudeman, Julie, Reinhart, Russell, Ogle, Chad, Coussens, Nathan P., Wright, John, Teicher, Beverly A., Doroshow, James H.

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Abstract 2644: Comparison of PDMR cell line complex spheroid response and PDX response to trametinib von Teicher, Beverly A., Coussens, Nathan P., Hollingshead, Melinda, Wright, John, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Reinhart, Russell, Ogle, Chad, Doroshow, James

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Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived M... von Dexheimer, Thomas S., Laudeman, Julie, Silvers, Thomas, Delosh, Rene, Reinhart, Russell, Ogle, Chad, Jones, Eric, Coussens, Nathan P., Teicher, Beverly A., Takebe, Naoko, Chen, Alice, Doroshow, James H.

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Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression von Teicher, Beverly A, Polley, Eric, Kunkel, Mark, Evans, David, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Connelly, John, Harris, Erik, Monks, Anne, Morris, Joel

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Abstract 328: DNA damage inhibitors with topotecan in a complex spheroid model in PDM and established cell lines von Teicher, Beverly A., Doyle, Austin, Wright, John, Kunos, Charles, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Reinhart, Russell, Ogle, Chad, Coussens, Nathan, Morris, Joel, Doroshow, James

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Abstract 1072: Combination screening of DNA damaging agents temozolomide and trabectedin with inhibitors of DNA repair using a complex spheroid model with a panel of patient-derive... von Coussens, Nathan P., Parchment, Ralph E., Moscow, Jeffrey A., Doyle, L. Austin, Delosh, René, Laudeman, Julie, Reinhart, Russell, Ogle, Chad, Silvers, Thomas, Dexheimer, Thomas S., Morris, Joel, Teicher, Beverly A., Doroshow, James H.

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Multicenter Clinical and Functional Evidence Reclassifies a Recurrent Non-canonical Filamin C Splice-altering Variant von O’Neill, Matthew J., Chen, Suet Nee, Rumping, Lynne, Johnson, Renee, van Slegtenhorst, Marjon, Glazer, Andrew M., Yang, Tao, Solus, Joseph F., Laudeman, Julie, Mitchell, Devyn W., Vanags, Loren R., Kroncke, Brett M., Anderson, Katherine, Gao, Shanshan, Verdonschot, Job A.J., Brunner, Han, Hellebrekers, Debby, Taylor, Matthew R.G., Roden, Dan M., Wessels, Marja W., Deprez, Ronald H. Lekanne Dit, Fatkin, Diane, Mestroni, Luisa, Shoemaker, M. Benjamin

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Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant von O’Neill, Matthew J., Chen, Suet Nee, Rumping, Lynne, Johnson, Renee, van Slegtenhorst, Marjon, Glazer, Andrew M., Yang, Tao, Solus, Joseph F., Laudeman, Julie, Mitchell, Devyn W., Vanags, Loren R., Kroncke, Brett M., Anderson, Katherine, Gao, Shanshan, Verdonschot, Job A.J., Brunner, Han, Hellebrekers, Debby, Taylor, Matthew R.G., Roden, Dan M., Wessels, Marja W., Lekanne Dit Deprez, Ronald H., Fatkin, Diane, Mestroni, Luisa, Shoemaker, M. Benjamin

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Exposure time versus cytotoxicity for anticancer agents von Evans, David M., Fang, Jianwen, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Bowles, Lori, Connelly, John, Harris, Erik, Krushkal, Julia, Rubinstein, Larry, Doroshow, James H., Teicher, Beverly A.

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Abstract 605: Building better cell models for screening oncology compounds von Evans, David M., Selby, Michael, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Silvers, Thomas, Parchment, Ralph E., Teicher, Beverly

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Abstract A150: Complex 3D cultures for combination compound screens reveal new insights von Evans, David M., Michael, Selby H., Bowles, Lori, Delosh, Rene M., Julie, Laudeman, Ogle, Chad C., Russell, Reinhart, Thomas, Silvers, Parchment, Ralph, Doroshow, James, Teicher, Beverly

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Abstract 348: Comparison of the response of the NCI60 NSCLC panel with the response of patient-derived NSCLC lines to approved and investigational agents von Teicher, Beverly A., Evans, David, Silvers, Thomas, Selby, Michael, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Morris, Joel, Kaur, Gurmeet, Doroshow, James

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Abstract 4831: Small cell lung carcinoma (SCLC) cell line screen of standard of care (etoposide/carboplatin) plus a third agent von Teicher, Beverly A., Selby, Michael, Silvers, Thomas, Laudeman, Julie, Reinhart, Russell, Delosh, Rene, Ogle, Chad, Parchment, Ralph, Krushkal, Julia, Sonkin, Dmitriy, Morris, Joel, Kunkel, Mark, Evans, David

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Abstract 1054: RAS-pathway inhibitors (Sotorasib, MRTX-1257, TNO-155, BI-3406) in a Complex Spheroid Combination Screen with PDMR Cell Lines von Takebe, Naoko, Dexheimer, Thomas, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Paul, Siddhartha, Reinhardt, Russell, Ogle, Chad, Morris, Joel, Coussens, Nathan, Doroshow, James H., Teicher, Beverly A.

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Abstract 5406: Osteosarcoma cell lines response to approved and investigational anticancer agents and statins along with gene and microRNA expression von Kaur, Gurmeet, Polley, Eric, Morris, Joel, Silvers, Thomas, Selby, Michael, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Monks, Anne, Rapisarda, Annamaria, Evans, David, Teicher, Beverly A.

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