Inefficient CAR-proximal signaling blunts antigen sensitivity von Gudipati, Venugopal, Rydzek, Julian, Doel-Perez, Iago, Gonçalves, Vasco Dos Reis, Scharf, Lydia, Königsberger, Sebastian, Lobner, Elisabeth, Kunert, Renate, Einsele, Hermann, Stockinger, Hannes, Hudecek, Michael, Huppa, Johannes B.

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SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes von Gogishvili, Tea, Danhof, Sophia, Prommersberger, Sabrina, Rydzek, Julian, Schreder, Martin, Brede, Christian, Einsele, Hermann, Hudecek, Michael

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CAR T-cells targeting FLT3 have potent activity against FLT3−ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib von Jetani, Hardikkumar, Garcia-Cadenas, Irene, Nerreter, Thomas, Thomas, Simone, Rydzek, Julian, Meijide, Javier Briones, Bonig, Halvard, Herr, Wolfgang, Sierra, Jordi, Einsele, Hermann, Hudecek, Michael

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Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform von Rydzek, Julian, Nerreter, Thomas, Peng, Haiyong, Jutz, Sabrina, Leitner, Judith, Steinberger, Peter, Einsele, Hermann, Rader, Christoph, Hudecek, Michael

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A Novel Pharmacologic ‘Remote Control’ to Steer CAR-T Cell Function In Vivo von Mestermann, Katrin, Rydzek, Julian, Silke, Frenz, Nerreter, Thomas, Andreas, Mades, Einsele, Hermann, Hudecek, Michael

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Abstract A037: A novel pharmacologic “ON/OFF” switch to modulate CAR-T-cell function in vitro and in vivo von Mestermann, Katrin, Julian, Rydzek, Silke, Frenz, Hermann, Einsele, Hudecek, Michael

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CAR T Cells Targeting FLT3 on AML Confer Potent Anti-Leukemic Activity and Act Synergistically with the FLT3 Inhibitor Midostaurin von Jetani, Hardikkumar, García-Cadenas, Irene, Nerreter, Thomas, Rydzek, Julian, Thomas, Simone, Herr, Wolfgang, Sierra, Jordi, Bönig, Halvard, Einsele, Hermann, Hudecek, Michael

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Abstract A028: Memory stem T-cells expressing an optimized CD30-specific chimeric antigen receptor (CAR) efficiently eradicate peripheral T-cell lymphoma in vivo von Escribà-Garcia, Laura, Alvarez-Fernández, Carmen, Caballero, Ana Carolina, Julian, Rydzek, Hermann, Einsele, Sierra, Jorge, Hudecek, Michael, Briones, Javier

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Abstract 1521: Combining a PRAME-specific TCR showing potent in vitro and in vivo anti-tumor reactivity and a favorable preclinical safety profile with a PD1-41BB switch receptor r... von Fetzer, Ina, Sailer, Nadja, Salvermoser, Melanie, Weis, Manon, Krendl, Christian, Bürdek, Maja, Brechtefeld, Doris, Rampp, Isabella, Rydzek-Wiesner, Julian, Braun, Monika, Ellinger, Christian, Geiger, Christiane, Sommermeyer, Daniel, Wilde, Susanne

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