Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process von Islam, Imadul, Yuan, Shendong, Wei, Robert G., Xu, Wei, Morrissey, Michael, Mohan, Raju, Zheng, Dewan, DiMella, Andrea, Dunning, Laura, Snider, Michael, Subramanyam, Babu, Tseng, Jih-Lie, Bryant, Judi A., Buckman, Brad O.

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1 von Feldman, Richard I., Wu, James M., Polokoff, Mark A., Kochanny, Monica J., Dinter, Harald, Zhu, Daguang, Biroc, Sandra L., Alicke, Bruno, Bryant, Judi, Yuan, Shendong, Buckman, Brad O., Lentz, Dao, Ferrer, Mike, Whitlow, Marc, Adler, Marc, Finster, Silke, Chang, Zheng, Arnaiz, Damian O.

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A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) – Part I: Pharmacological characterization von Wang, Yi-Xin, Zhao, Lei, Nagashima, Mariko, Vincelette, Jon, Sukovich, Drew, Li, Weiwei, Subramanyam, Babu, Yuan, Shendong, Emayan, Kumar, Islam, Imadul, Hrvatin, Paul, Bryant, Judi, Light, David R., Vergona, Ronald, Morser, John, Buckman, Brad O.

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Host-guest complexation. 62. Solvophobic and entropic driving forces for forming velcraplexes, which are 4-fold, lock-key dimers in organic media von Cram, Donald J, Choi, Heung Jin, Bryant, Judi A, Knobler, Carolyn B

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Potent Triazolothione Inhibitor of Heat-Shock Protein-90 von Feldman, Richard I, Mintzer, Bob, Zhu, Daguang, Wu, James M, Biroc, Sandra L, Yuan, Shendong, Emayan, Kumar, Chang, Zheng, Chen, Deborah, Arnaiz, Damian O, Bryant, Judi, Ge, Xue Snow, Whitlow, Marc, Adler, Marc, Polokoff, Mark A, Li, Wei-Wei, Ferrer, Mike, Sato, Takashi, Gu, Jian-Ming, Shen, Jun, Tseng, Jih-Lie, Dinter, Harald, Buckman, Brad

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Host-guest complexation. 48. Octol building blocks for cavitands and carcerands von Tunstad, Linda M, Tucker, John A, Dalcanale, Enrico, Weiser, Jurgen, Bryant, Judi A, Sherman, John C, Helgeson, Roger C, Knobler, Carolyn B, Cram, Donald J

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Vases and kites as cavitands von Moran, John R, Ericson, John L, Dalcanale, Enrico, Bryant, Judi A, Knobler, Carolyn B, Cram, Donald J

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Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis von Islam, Imadul, Yuan, Shendong, West, Christopher W., Adler, Marc, Bothe, Ulrich, Bryant, Judi, Chang, Zheng, Chu, Kieu, Emayan, Kumar, Gualtieri, Giovanna, Ho, Elena, Light, David, Mallari, Cornell, Morser, John, Phillips, Gary, Schaefer, Caralee, Sukovich, Drew, Whitlow, Marc, Chen, Deborah, Buckman, Brad O.

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Host-guest complexation. 55. Guest capture during shell closure von Bryant, Judi A, Blanda, Michael T, Vincenti, Marco, Cram, Donald J

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517 von Islam, Imadul, Brown, Greg, Bryant, Judi, Hrvatin, Paul, Kochanny, Monica J., Phillips, Gary B., Yuan, Shendong, Adler, Marc, Whitlow, Marc, Lentz, Dao, Polokoff, Mark A., Wu, James, Shen, Jun, Walters, Janette, Ho, Elena, Subramanyam, Babu, Zhu, Daguang, Feldman, Richard I., Arnaiz, Damian O.

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A novel P2Y12 adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models von Wang, Yi-Xin, Vincelette, Jon, Cunha, Valdeci da, Martin-McNulty, Baby, Mallari, Cornell, Fitch, Richard M., Alexander, Serene, Islam, Imadul, Buckman, Brad O., Yuan, Shendong, Post, Joseph M., Subramanyam, Babu, Vergona, Ronald, Sullivan, Mark E., Dole, William P., Morser, John, Bryant, Judi

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity von Islam, Imadul, Bryant, Judi, Chou, Yuo-Ling, Kochanny, Monica J., Lee, Wheeseong, Phillips, Gary B., Yu, Hongyi, Adler, Marc, Whitlow, Marc, Ho, Elena, Lentz, Dao, Polokoff, Mark A., Subramanyam, Babu, Wu, James M., Zhu, Daguang, Feldman, Richard I., Arnaiz, Damian O.

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Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA) von West, Christopher W., Adler, Marc, Arnaiz, Danny, Chen, Deborah, Chu, Kieu, Gualtieri, Giovanna, Ho, Elena, Huwe, Christoph, Light, David, Phillips, Gary, Pulk, Rebecca, Sukovich, Drew, Whitlow, Marc, Yuan, Shendong, Bryant, Judi

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Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization von Post, Joseph M, Alexander, Serene, Wang, Yi-Xin, Vincelette, Jon, Vergona, Ron, Kent, Lorraine, Bryant, Judi, Sullivan, Mark E, Dole, William P, Morser, John, Subramanyam, Babu

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A novel P2Y adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models von Wang, Yi-Xin, Vincelette, Jon, da Cunha, Valdeci, Martin-McNulty, Baby, Mallari, Cornell, Fitch, Richard M, Alexander, Serene, Islam, Imadul, Buckman, Brad O, Yuan, Shendong, Post, Joseph M, Subramanyam, Babu, Vergona, Ronald, Sullivan, Mark E, Dole, William P, Morser, John, Bryant, Judi

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3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) von Islam, Imadul, Bryant, Judi, May, Karen, Mohan, Raju, Yuan, Shendong, Kent, Lorraine, Morser, John, Zhao, Lei, Vergona, Ron, White, Kathy, Adler, Marc, Whitlow, Marc, Buckman, Brad O.

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High preorganization of large lipophilic surfaces common to two complexing partners provides high binding free energies that vary dramatically with changes in organic solvent compo... von Bryant, Judi A, Ericson, John L, Cram, Donald J

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Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets von Bryant, Judi, Post, Joseph M, Alexander, Serene, Wang, Yi-Xin, Kent, Lorraine, Schirm, Sabine, Tseng, Jih-Lie, Subramanyam, Babu, Buckman, Brad, Islam, Imadul, Yuan, Shendong, Sullivan, Mark E, Snider, Mike, Morser, John

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Crystal Structures of Potent Thiol-Based Inhibitors Bound to Carboxypeptidase B von Adler, Marc, Bryant, Judi, Buckman, Brad, Islam, Imadul, Larsen, Brent, Finster, Silke, Kent, Lorraine, May, Karen, Mohan, Raju, Yuan, Shendong, Whitlow, Marc

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Solvophobic and entropic driving forces for forming velcraplexes, which are four-fold, lock-key dimers in organic media von CRAM, D. J, HEUNG-JIN CHOI, BRYANT, J. A, KNOBLER, C. B

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