Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study von Antonia, Scott, Prof, Goldberg, Sarah B, MD, Balmanoukian, Ani, MD, Chaft, Jamie E, MD, Sanborn, Rachel E, MD, Gupta, Ashok, MD, Narwal, Rajesh, PhD, Steele, Keith, PhD, Gu, Yu, PhD, Karakunnel, Joyson J, MD, Rizvi, Naiyer A, Prof

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Reviewing the role of healthy volunteer studies in drug development von Karakunnel, Joyson J, Bui, Nam, Palaniappan, Latha, Schmidt, Keith T, Mahaffey, Kenneth W, Morrison, Briggs, Figg, William D, Kummar, Shivaani

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Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors von Arbour, Kathryn C, Naidoo, Jarushka, Steele, Keith E, Ni, Ai, Moreira, Andre L, Rekhtman, Natasha, Robbins, Paul B, Karakunnel, Joyson, Rimner, Andreas, Huang, James, Riely, Gregory J, Hellmann, Matthew D

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Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers von Seitz, Lisa, Jin, Lixia, Leleti, Manmohan, Ashok, Devika, Jeffrey, Jenna, Rieger, Aimee, Tiessen, Renger G., Arold, Gerhard, Tan, Joanne B. L., Powers, Jay P., Walters, Matthew J., Karakunnel, Joyson

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Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker... von Friedman, Claire F, Spencer, Christine, Cabanski, Christopher R, Panageas, Katherine S, Wells, Daniel K, Ribas, Antoni, Tawbi, Hussein, Tsai, Katy, Postow, Michael, Shoushtari, Alexander, Chapman, Paul, Karakunnel, Joyson, Bucktrout, Samantha, Gherardini, Pier, Hollmann, Travis J, Chen, Richard O, Callahan, Margaret, LaVallee, Theresa, Ibrahim, Ramy, Wolchok, Jedd

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Phase II clinical trial of cediranib in patients with metastatic castration‐resistant prostate cancer von Dahut, William L., Madan, Ravi A., Karakunnel, Joyson J., Adelberg, David, Gulley, James L., Turkbey, Ismail B., Chau, Cindy H., Spencer, Shawn D., Mulquin, Marcia, Wright, John, Parnes, Howard L., Steinberg, Seth M., Choyke, Peter L., Figg, William D.

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Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies von Naing, Aung, Infante, Jeffrey, Goel, Sanjay, Burris, Howard, Black, Chelsea, Marshall, Shannon, Achour, Ikbel, Barbee, Susannah, May, Rena, Morehouse, Chris, Pollizzi, Kristen, Song, Xuyang, Steele, Keith, Elgeioushi, Nairouz, Walcott, Farzana, Karakunnel, Joyson, LoRusso, Patricia, Weise, Amy, Eder, Joseph, Curti, Brendan, Oberst, Michael

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Safety and efficacy of durvalumab (MEDI4736) plus tremelimumab in advanced non-small-cell lung cancer (NSCLC) von Karakunnel, Joyson J.

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Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial von Padrón, Lacey J., Maurer, Deena M., O’Hara, Mark H., O’Reilly, Eileen M., Wolff, Robert A., Wainberg, Zev A., Ko, Andrew H., Fisher, George, Rahma, Osama, Lyman, Jaclyn P., Cabanski, Christopher R., Yu, Jia Xin, Pfeiffer, Shannon M., Spasic, Marko, Xu, Jingying, Gherardini, Pier Federico, Karakunnel, Joyson, Mick, Rosemarie, Alanio, Cécile, Byrne, Katelyn T., Hollmann, Travis J., Moore, Jonni S., Jones, Derek D., Tognetti, Marco, Chen, Richard O., Yang, Xiaodong, Salvador, Lisa, Wherry, E. John, Dugan, Ute, O’Donnell-Tormey, Jill, Butterfield, Lisa H., Hubbard-Lucey, Vanessa M., Ibrahim, Ramy, Fairchild, Justin, Bucktrout, Samantha, LaVallee, Theresa M., Vonderheide, Robert H.

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CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, mult... von O'Hara, Mark H, O'Reilly, Eileen M, Varadhachary, Gauri, Wolff, Robert A, Wainberg, Zev A, Ko, Andrew H, Fisher, George, Rahma, Osama, Lyman, Jaclyn P, Cabanski, Christopher R, Mick, Rosemarie, Gherardini, Pier Federico, Kitch, Lacey J, Xu, Jingying, Samuel, Theresa, Karakunnel, Joyson, Fairchild, Justin, Bucktrout, Samantha, LaVallee, Theresa M, Selinsky, Cheryl, Till, Jacob E, Carpenter, Erica L, Alanio, Cécile, Byrne, Katelyn T, Chen, Richard O, Trifan, Ovid C, Dugan, Ute, Horak, Christine, Hubbard-Lucey, Vanessa M, Wherry, E John, Ibrahim, Ramy, Vonderheide, Robert H

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Feasibility and utility of synthetic control arms derived from real-world data to support clinical development von Lyman, Jaclyn Paige, Doucette, Abigail, Zheng-Lin, Binbin, Cabanski, Christopher R., Maloy, Molly A., Bayless, Nicholas L., Xu, Jingying, Smith, William, Karakunnel, Joyson Joseph, Fairchild, Justin P., Ibrahim, Ramy, O'Reilly, Eileen Mary, Vonderheide, Robert H., Gabriel, Peter Edward

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Abstract 5045: Pharmacokinetics and pharmacodynamics of MEDI0680, a fully human anti-PD1 monoclonal antibody, in patients with advanced malignancies von Song, Xuyang, Gao, Xizhe, Zheng, Bo, Black, Chelsea, Gribbin, Matthew, Karakunnel, Joyson, Roskos, Lorin, Narwal, Rajesh

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Gemcitabine (Gem) and nab-paclitaxel (NP) ± nivolumab (nivo) ± CD40 agonistic monoclonal antibody APX005M (sotigalimab), in patients (Pts) with untreated metastatic pancreatic aden... von O'Hara, Mark H., O'Reilly, Eileen Mary, Wolff, Robert A., Wainberg, Zev A., Ko, Andrew H., Rahma, Osama E., Fisher, George A., Lyman, Jaclyn Paige, Cabanski, Christopher R., Karakunnel, Joyson Joseph, Gherardini, Pier Federico, Kitch, Lacey J., Bucktrout, Samantha, Christopher, Elizabeth, Mick, Rosemarie, Chen, Richard, Trifan, Ovidiu C., Salvador, Lisa, O'Donnell-Tormey, Jill, Vonderheide, Robert H.

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AB928, a novel dual adenosine receptor antagonist, combined with chemotherapy or AB122 (anti-PD-1) in patients (pts) with advanced tumors: Preliminary results from ongoing phase I... von Powderly, John D., de Souza, Paul L., Gutierrez, Rodolfo, Horvath, Lisa, Seitz, Lisa, Ashok, Devika, Park, Adam, Walters, Matthew J., Karakunnel, Joyson Joseph, Berry, Wade, Rieger, Aimee, Garofalo, Amanda, Lai, Dominic W., Chaudhry, Arvind

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Abstract 3769: Pharmacokinetic-pharmacodynamic relationship for AB928, a dual antagonist of the A2aR and A2bR adenosine receptors von Seitz, Lisa, Ashok, Devika, Leleti, Manmohan R., Powers, Jay P., Rosen, Brandon, Miles, Dillon, Jin, Lixia, Park, Adam, Park, Tim, Young, Steve, Soriano, Ferdie, Rieger, Aimee, Schindler, Ulrike, Karakunnel, Joyson, Walters, Matt J.

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Phase I, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in pa... von Hamid, Omid, Chow, Laura Quan Man, Tavakkoli, Fatemeh, Marshall, Shannon, Gribbin, Matthew Joseph, Karakunnel, Joyson Joseph, Gray, Jhanelle Elaine

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Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with... von Creelan, Ben C., Chow, Laura Q., Kim, Dong-Wan, Kim, Sang-We, Yeh, Tammie, Karakunnel, Joyson Joseph, Gibbons, Don Lynn

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A Phase 1 study of MEDI1873 in adult patients with select advanced solid tumors von Balmanoukian, Ani Sarkis, Antonia, Scott Joseph, Stewart, Ross A., Black, Chelsea, Wang, Fujun, Antal, Joyce, Karakunnel, Joyson Joseph, Infante, Jeffrey R.

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Safety and antitumour activity in a phase 1b study of combined checkpoint blockade with anti-PD-L1 (durvalumab) and anti-CTLA4 (tremelimumab) in non-small cell lung cancer von Antonia, Scott, Goldberg, Sarah B., Balmanoukian, Ani, Chaft, Jamie E., Sanborn, Rachel E., Gupta, Ashok, Narwal, Rajesh, Steele, Keith, Gu, Yu, Karakunnel, Joyson Joseph, Rizvi, Naiyer A.

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Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in... von Antonia, Scott Joseph, Goldberg, Sarah B., Balmanoukian, Ani Sarkis, Sanborn, Rachel E., Steele, Keith, Narwal, Rajesh, Robbins, Paul B., Gu, Yu, Karakunnel, Joyson Joseph, Rizvi, Naiyer A.

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