Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 von Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

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Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists von Chandramohan, Arun, Josien, Hubert, Yuen, Tsz Ying, Duggal, Ruchia, Spiegelberg, Diana, Yan, Lin, Juang, Yu-Chi Angela, Ge, Lan, Aronica, Pietro G., Kaan, Hung Yi Kristal, Lim, Yee Hwee, Peier, Andrea, Sherborne, Brad, Hochman, Jerome, Lin, Songnian, Biswas, Kaustav, Nestor, Marika, Verma, Chandra S., Lane, David P., Sawyer, Tomi K., Garbaccio, Robert, Henry, Brian, Kannan, Srinivasaraghavan, Brown, Christopher J., Johannes, Charles W., Partridge, Anthony W.

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Discovery of a Novel, Potent Spirocyclic Series of γ‑Secretase Inhibitors von Zhao, Zhiqiang, Pissarnitski, Dmitri A, Josien, Hubert B, Wu, Wen-Lian, Xu, Ruo, Li, Hongmei, Clader, John W, Burnett, Duane A, Terracina, Giuseppe, Hyde, Lynn, Lee, Julie, Song, Lixin, Zhang, Lili, Parker, Eric M

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Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors von Zhao, Zhiqiang, Pissarnitski, Dmitri A., Josien, Hubert B., Bara, Thomas A., Clader, John W., Li, Hongmei, McBriar, Mark D., Rajagopalan, Murali, Xu, Ruo, Terracina, Giuseppe, Hyde, Lynn, Song, Lixin, Zhang, Lili, Parker, Eric M., Osterman, Rebecca, Buevich, Alexei V.

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A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays von Kasper, Stephen H, Otten, Stephanie, Squadroni, Brian, Orr-Terry, Cionna, Kuang, Yi, Mussallem, Lily, Ge, Lan, Yan, Lin, Kannan, Srinivasaraghavan, Verma, Chandra S, Brown, Christopher J, Johannes, Charles W, Lane, David P, Chandramohan, Arun, Partridge, Anthony W, Roberts, Lee R, Josien, Hubert, Therien, Alex G, Hett, Erik C, Howell, Bonnie J, Peier, Andrea, Ai, Xi, Cassaday, Jason

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A General Synthetic Approach to the (20S)-Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles von Josien, Hubert, Ko, Sung-Bo, Bom, David, Curran, Dennis P.

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Tetrahydroquinoline sulfonamides as γ-secretase inhibitors von Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Zhang, Lili, Zhao, Zhiqiang

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Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors von Li, Hongmei, Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Josien, Hubert B., McBriar, Mark D., Nomeir, Amin, Pissarnitski, Dmitri A., Rajagopalan, Murali, Xu, Ruo, Zhao, Zhiqiang, Song, Lixin, Zhang, Lili

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors von Pissarnitski, Dmitri A., Asberom, Theodros, Bara, Thomas A., Buevich, Alex V., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, McEwan, Michael, McKittrick, Brian A., Nechuta, Terry L., Parker, Eric M., Sinning, Lisa, Smith, Elizabeth M., Song, Lixin, Vaccaro, Henry A., Voigt, Johannes H., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang

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Synthesis of ( S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles von Josien, Hubert, Curran, Dennis P.

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Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease von Asberom, Theodros, Zhao, Zhiqiang, Bara, Thomas A., Clader, John W., Greenlee, William J., Hyde, Lynn A., Josien, Hubert B., Li, Wei, McPhail, Andrew T., Nomeir, Amin A., Parker, Eric M., Rajagopalan, Murali, Song, Lixin, Wong, Gwendolyn T., Zhang, Lili, Zhang, Qi, Pissarnitski, Dmitri A.

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor von Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas M., Wood, Harold B.

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Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester von Shang, Jackie, Tschirret-Guth, Richard, Cancilla, Mark, Samuel, Koppara, Chen, Qing, Chobanian, Harry R, Thomas, Ann, Tong, Wei, Josien, Hubert, Buevich, Alexei V, Mitra, Kaushik

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Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists von Chandramohan, Arun, Josien, Hubert, Yuen, Tsz Ying, Duggal, Ruchia, Spiegelberg, Diana, Yan, Lin, Angela Juang, Yu-Chi, Ge, Lan, Aronica, Pietro, Kaan, Kristal, Lim, Yee Hwee, Peier, Andrea, Sherborne, Brad, Hochman, Jerome, Lin, Songnian, Biswas, Kaustav, Henry, Brian, Nestor, Marika, Verma, Chandra S, Lane, David, Sawyer, Tomi, Garbaccio, Robert, Kannan, Srinivasaraghavan, Brown, Christopher J., Johannes, Charles W, Partridge, Anthony William

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation von Wong, Gwendolyn T., Manfra, Denise, Poulet, Frederique M., Zhang, Qi, Josien, Hubert, Bara, Thomas, Engstrom, Laura, Pinzon-Ortiz, Maria, Fine, Jay S., Lee, Hu-Jung J., Zhang, Lili, Higgins, Guy A., Parker, Eric M.

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SAR of tricyclic sulfones as γ-secretase inhibitors von Xu, Ruo, Cole, David, Asberom, Ted, Bara, Tom, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Hyde, Lynn, Josien, Hubert, Li, HongMei, McBriar, Mark, McKittrick, Brian, Pissarnitski, Dmitri, Qiang, Li, Rajagopalan, Murali, Sasikumar, Thavalakulamgara, Su, Jing, Tang, HaiQun, Wu, Wen-Lian, Zhang, LiLi, Zhao, ZhiQiang

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor von Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas, Wood, Harold B.

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Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol von Vice, Susan, Bara, Tom, Bauer, Annette, Evans, C. Anderson, Ford, Jennifer, Josien, Hubert, McCombie, Stuart, Miller, Michael, Nazareno, Dennis, Palani, Anandan, Tagat, Jay

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Synthesis of Mono- and Difluoronaphthoic Acids von Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis V, Boyle, Craig D, Kozlowski, Joseph A, Chackalamannil, Samuel, Josien, Hubert, Wang, Yuguang, Zhou, Guowei

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs von Pio, Barbara, Chobanian, Harry R., Guo, Yan, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Ashley, Eric, Orr, Robert, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Samuel, Koppara, Chen, Qing, Shang, Jackie, Lamca, James, Ehrhart, Juliann, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.

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