Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Pol... von Joshi, Poorval M., Sutor, Shari L., Huntoon, Catherine J., Karnitz, Larry M.

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Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination von Huehls, Amelia M, Huntoon, Catherine J, Joshi, Poorval M, Baehr, Carly A, Wagner, Jill M, Wang, Xiaoxiao, Lee, Marietta Y, Karnitz, Larry M

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Abstract POSTER-BIOL-1325: Ovarian cancer-associated CDK12 mutations disable its kinase activity and cause defects in homologous recombination von Joshi, Poorval M., Sutor, Shari L., Huntoon, Catherine J., Karnitz, Larry M.

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Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies von Biancon, Giulia, Joshi, Poorval, Zimmer, Joshua T., Hunck, Torben, Gao, Yimeng, Lessard, Mark D., Courchaine, Edward, Barentine, Andrew E.S., Machyna, Martin, Botti, Valentina, Qin, Ashley, Gbyli, Rana, Patel, Amisha, Song, Yuanbin, Kiefer, Lea, Viero, Gabriella, Neuenkirchen, Nils, Lin, Haifan, Bewersdorf, Joerg, Simon, Matthew D., Neugebauer, Karla M., Tebaldi, Toma, Halene, Stephanie

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U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies von Biancon, Giulia, Joshi, Poorval, Zimmer, Joshua T, Hunck, Torben, Gao, Yimeng, Lessard, Mark D, Courchaine, Edward, Barentine, Andrew ES, Machyna, Martin, Botti, Valentina, Qin, Ashley, Gbyli, Rana, Patel, Amisha, Song, Yuanbin, Kiefer, Lea, Viero, Gabriella, Neuenkirchen, Nils, Lin, Haifan, Bewersdorf, Joerg, Simon, Matthew D, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie

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High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies von Biancon, Giulia, Joshi, Poorval, Hunck, Torben, Zimmer, Josh, Gao, Yimeng, Machyna, Martin, Botti, Valentina, Qin, Ashley, Viero, Gabriella, Neuenkirchen, Nils, Taylor, Ashley, Gbyli, Rana, Patel, Amisha, Ardasheva, Anastasia, Fu, Xiaoying, Lin, Haifan, Simon, Matthew D, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie

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U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA Complex von Biancon, Giulia, Joshi, Poorval, Hunck, Torben, Gao, Yimeng, Botti, Valentina, Qin, Ashley, Sadykov, Mukhtar, Wang, Xiaman, Viero, Gabriella, Neuenkirchen, Nils, Taylor, Ashley, Huang, Jane, Ardasheva, Anastasia, Fu, Xiaoying, Lin, Haifan, Pillai, Manoj M, Kielkopf, Clara L, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie

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