Lipophilic nalmefene prodrugs to achieve a one-month sustained release von Gaekens, Tim, Guillaume, Michel, Borghys, Herman, De Zwart, Loeckie L., de Vries, Ronald, Embrechts, Roger C.A., Vermeulen, An, Megens, Anton A.H.P., Leysen, Josée E., Herdewijn, Piet, Annaert, Pieter P., Atack, John R.

Volltext

Preclinical evaluation of [18 F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors von Golla, Sandeep S.V, Klein, Pieter J, Bakker, Jaco, Schuit, Robert C, Christiaans, Johannes A.M, van Geest, Leo, Kooijman, Esther J.M, Oropeza-Seguias, Gisela M, Langermans, Jan A.M, Leysen, Josée E, Boellaard, Ronald, Windhorst, Albert D, van Berckel, Bart N.M, Metaxas, Athanasios

Volltext

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound von Briejer, Michel R, Bosmans, Jean-Paul, Van Daele, Paul, Jurzak, Mirek, Heylen, Lieve, Leysen, Josee E, Prins, Nicolaas H, Schuurkes, Jan A.J

Volltext

Evaluation of [11 C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats von Luurtsema, Gert, Schuit, Robert C, Klok, Rob P, Verbeek, Joost, Leysen, Josée E, Lammertsma, Adriaan A, Windhorst, Albert D

Volltext

The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects von Tolboom, Nelleke, Berendse, Henk W, Leysen, Josee E, Yaqub, Maqsood, van Berckel, Bart N M, Schuit, Robert C, Ponsen, Mirthe M, Bakker, Esther, Hoetjes, Nikie J, Windhorst, Albert D, Carlsson, Maria L, Lammertsma, Adriaan A, Carlsson, Arvid

Volltext

Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand von Airaksinen, Anu J, Jablonowski, Jill A, van der Mey, Margreet, Barbier, Ann J, Klok, Rob P, Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D M, Leysen, Josee E, Carruthers, Nicholas I, Lammertsma, Adriaan A, Windhorst, Albert D

Volltext

First Evaluation of [11C]R116301 as an In Vivo Tracer of NK1 Receptors in Man von Wolfensberger, Saskia P. A., van Berckel, Bart N. M., Airaksinen, Anu J., Maruyama, Kaoru, Lubberink, Mark, Boellaard, Ronald, Carey, William D. H., Reddingius, Wieb, Veltman, Dick J., Windhorst, Albert D., Leysen, Josée E., Lammertsma, Adriaan A.

Volltext

Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexan... von Al Hussainy, Rana, Verbeek, Joost, van der Born, Dion, Braker, Anton H, Leysen, Josée E, Knol, Remco J, Booij, Jan, Herscheid, J. (Koos) D. M

Volltext

Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells von Ledeboer, Annemarie, Brevé, John J. P., Wierinckx, Anne, Van Der Jagt, Saskia, Bristow, Adrian F., Leysen, Josée E., Tilders, Fred J. H., Van Dam, Anne-Marie

Volltext

Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NM... von Christiaans, Johannes A.M, Klein, Pieter J, Metaxas, Athanasios, Kooijman, Esther J.M, Schuit, Robert C, Leysen, Josée E, Lammertsma, Adriaan A, van Berckel, Bart N.M, Windhorst, Albert D

Volltext

[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists von Lavreysen, Hilde, Janssen, Cor, Bischoff, François, Langlois, Xavier, Leysen, Josée E., Lesage, Anne S.J.

Volltext

[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors von Buiter, Hans JC, Windhorst, Albert D, Huisman, Marc C, Yaqub, Maqsood, Knol, Dirk L, Fisher, Abraham, Lammertsma, Adriaan A, Leysen, Josée E

Volltext

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor von Van Craenenbroeck, Kathleen, Gellynck, Evelien, Lintermans, Béatrice, Leysen, Josée E., Van Tol, Hubert H.M., Haegeman, Guy, Vanhoenacker, Peter

Volltext

Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [ 3H]R214127 von Lavreysen, Hilde, Pereira, Sandrina Nóbrega, Leysen, Joseé E, Langlois, Xavier, Lesage, Anne S.J

Volltext

Radiosynthesis and biological evaluation of the M1 muscarinic acetylcholine receptor agonist ligand [11C]AF150(S) von Buiter, Hans J.C., Leysen, Josée E., Schuit, Robert C., Fisher, Abraham, Lammertsma, Adriaan A., Windhorst, Albert D.

Volltext

Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐[3H]3methoxy phenyl)‐N′‐methylguanidine ([3H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagon... von Metaxas, Athanasios, van Berckel, Bart N. M., Klein, Pieter J., Verbeek, Joost, Nash, Emily C., Kooijman, Esther J. M., Renjaän, Véronique A., Golla, Sandeep S. V., Boellaard, Ronald, Christiaans, Johannes A. M., Windhorst, Albert D., Leysen, Josée E.

Volltext

Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor von Buiter, Hans JC, Windhorst, Albert D, Huisman, Marc C, De Maeyer, Joris H, Schuurkes, Jan AJ, Lammertsma, Adriaan A, Leysen, Josée E

Volltext

Quantification of the neurokinin 1 receptor ligand [11C]R116301 von Wolfensberger, Saskia P, Maruyama, Kaoru, van Berckel, Bart N, Lubberink, Mark, Airaksinen, Anu J, Boellaard, Ronald, Luurtsema, Gert, Reddingius, Wieb, Janssens, Frans E, Veltman, Dick J, Windhorst, Albert D, Leysen, Josée E, Lammertsma, Adriaan A

Volltext

5-HT2A and 5-HT2C receptors and their atypical regulation properties von Van Oekelen, Dirk, Luyten, Walter H.M.L, Leysen, Josée E

Volltext

Functional study of rat 5‐HT2A receptors using antisense oligonucleotides von Van Oekelen, Dirk, Megens, Anton, Meert, Theo, Luyten, Walter H. M. L., Leysen, Josée E.

Volltext