SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors von Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen

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Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)‑N‑((S)‑3-(Cyclopent-1-en-1-yl)-1-((R)‑2-methyloxiran-2-y... von Johnson, Henry W. B, Lowe, Eric, Anderl, Janet L, Fan, Andrea, Muchamuel, Tony, Bowers, Simeon, Moebius, David C, Kirk, Christopher, McMinn, Dustin L

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Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis von Li, Jun, Hu, Shaobo, Johnson, Henry W B, Kirk, Christopher J, Xian, Peng, Song, Yanping, Li, Yuan, Liu, Nan, Groettrup, Marcus, Basler, Michael

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Abstract 2226: Prioritizing tumor types for clinical study of novel Sec61 inhibitors by searching for expression profiles of sensitive cell lines in tumor sample databases von Lowe, Eric, Fan, R. Andrea, Johnson, Henry W.B., Kirk, Christopher J., McMinn, Dustin, Qian, Yu, Tuch, Brian

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Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61 von Qian, Yu, Johnson, Henry W.B., Kirk, Christopher J., Lowe, Eric, McMinn, Dustin, Millare, Beatriz, Muchamuel, Tony, Wang, Jinhai

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Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies von Lowe, Eric, Fan, Andrea R, Jiang, Jing, Johnson, Henry W.B., Kirk, Christopher J., McMinn, Dustin, Muchamuel, Tony, Qian, Yu, Tuch, Brian B.

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Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses von Muchamuel, Tony, Fan, R Andrea, Anderl, Janet L, Bomba, Darrin J, Johnson, Henry W B, Lowe, Eric, Tuch, Brian B, McMinn, Dustin L, Millare, Beatriz, Kirk, Christopher J

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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR) von Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole

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Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit von Johnson, Henry W. B, Anderl, Janet L, Bradley, Erin K, Bui, John, Jones, Jeffrey, Arastu-Kapur, Shirin, Kelly, Lisa M, Lowe, Eric, Moebius, David C, Muchamuel, Tony, Kirk, Christopher, Wang, Zhengping, McMinn, Dustin

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Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors von Leahy, James W, Buhr, Chris A, Johnson, Henry W. B, Kim, Byung Gyu, Baik, TaeGon, Cannoy, Jonah, Forsyth, Timothy P, Jeong, Joon Won, Lee, Matthew S, Ma, Sunghoon, Noson, Kevin, Wang, Longcheng, Williams, Matthew, Nuss, John M, Brooks, Eric, Foster, Paul, Goon, Leanne, Heald, Nathan, Holst, Charles, Jaeger, Christopher, Lam, Scott, Lougheed, Julie, Nguyen, Lam, Plonowski, Arthur, Song, Joanne, Stout, Thomas, Wu, Xiang, Yakes, Michael F, Yu, Peiwen, Zhang, Wentao, Lamb, Peter, Raeber, Olivia

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A Polyether Biotoxin Binding Site on the Lipid-Exposed Face of the Pore Domain of KV Channels Revealed by the Marine Toxin Gambierol von Kopljar, Ivan, Labro, Alain J., Cuypers, Eva, Johnson, Henry W. B., Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J., Miller, Christopher

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The Total Synthesis of Gambierol von Johnson, Henry W. B, Majumder, Utpal, Rainier, Jon D

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Total Synthesis of Gambierol: The Generation of the A-C and F-H Subunits by Using a C-Glycoside Centered Strategy von Majumder, Utpal, Cox, Jason M., Johnson, Henry W. B., Rainier, Jon D.

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Total Synthesis of Gambierol: Subunit Coupling and Completion von Johnson, Henry W. B., Majumder, Utpal, Rainier, Jon D.

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Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists von Ibrahim, Mohamed A, Johnson, Henry W. B, Jeong, Joon Won, Lewis, Gary L, Shi, Xian, Noguchi, Robin T, Williams, Matthew, Leahy, James W, Nuss, John M, Woolfrey, John, Banica, Monica, Bentzien, Frauke, Chou, Yu-Chien, Gibson, Anna, Heald, Nathan, Lamb, Peter, Mattheakis, Larry, Matthews, David, Shipway, Aaron, Wu, Xiang, Zhang, WenTao, Zhou, Sihong, Shankar, Geetha

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C-Glycosides to fused polycyclic ethers von Allwein, Shawn P., Cox, Jason M., Howard, Brett E., Johnson, Henry W.B., Rainier, Jon D.

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A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol von Kopljar, Ivan, Labro, Alain J, Cuypers, Eva, Johnson, Henry W.B, Rainier, Jon D, Tytgat, Jan, Snyders, Dirk J

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