Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5 von Hsu, Mei-Hui, Johnson, Eric F.

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Structural Diversity of Eukaryotic Membrane Cytochrome P450s von Johnson, Eric F., Stout, C. David

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PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow von Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David

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Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding von Wang, An, Stout, C.David, Zhang, Qinghai, Johnson, Eric F.

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors von Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor von Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W

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Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2 von Sansen, Stefaan, Yano, Jason K., Reynald, Rosamund L., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.

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The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution von Yano, Jason K., Wester, Michael R., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.

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Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism von Annalora, Andrew J., Goodin, David B., Hong, Wen-Xu, Zhang, Qinghai, Johnson, Eric F., Stout, C. David

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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer von Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L

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Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection von Holdener, Martin, Hintermann, Edith, Bayer, Monika, Rhode, Antje, Rodrigo, Evelyn, Hintereder, Gudrun, Johnson, Eric F, Gonzalez, Frank J, Pfeilschifter, Josef, Manns, Michael P, Herrath, Matthias von G, Christen, Urs

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The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution von Wester, Michael R, Yano, Jason K, Schoch, Guillaume A, Yang, Christine, Griffin, Keith J, Stout, C David, Johnson, Eric F

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Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4 von Hsu, Mei-Hui, Johnson, Eric F.

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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases von Johnson, Eric F., Stout, C. David

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Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A von Shi, Yan, Solomon, Larry R., Pereda-Lopez, Ana, Giranda, Vincent L., Luo, Yan, Johnson, Eric F., Shoemaker, Alexander R., Leverson, Joel, Liu, Xuesong

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An Open Conformation of Mammalian Cytochrome P450 2B4 at 1.6-Å Resolution von Scott, Emily E., He, You Ai, Wester, Michael R., White, Mark A., Chin, Christopher C., Halpert, James R., Johnson, Eric F., Stout, C. David

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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain von Mast, Natalia, White, Mark Andrew, Bjorkhem, Ingemar, Johnson, Eric F, Stout, C. David, Pikuleva, Irina A

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Synthetic Inhibitors of Cytochrome P-450 2A6:  Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization von Yano, Jason K, Denton, Travis T, Cerny, Matthew A, Zhang, Xiaodong, Johnson, Eric F, Cashman, John R

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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) von Miyashiro, Julie, Woods, Keith W., Park, Chang H., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Luo, Yan, Fry, Elizabeth H., Giranda, Vincent L., Penning, Thomas D.

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A New Type of Sulfite Reductase, a Novel Coenzyme F420-dependent Enzyme, from the Methanarchaeon Methanocaldococcus jannaschii von Johnson, Eric F., Mukhopadhyay, Biswarup

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