Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury von Leaf, Irina A, Nakagawa, Shunsaku, Johnson, Bryce G, Cha, Jin Joo, Mittelsteadt, Kristen, Guckian, Kevin M, Gomez, Ivan G, Altemeier, William A, Duffield, Jeremy S

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Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis von Johnson, Bryce G, Dang, Lan T, Marsh, Graham, Roach, Allie M, Levine, Zebulon G, Monti, Anthony, Reyon, Deepak, Feigenbaum, Lionel, Duffield, Jeremy S

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LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1 von Ren, Shuyu, Johnson, Bryce G., Kida, Yujiro, Ip, Colin, Davidson, Kathryn C., Lin, Shuei-Liong, Kobayashi, Akio, Lang, Richard A., Hadjantonakis, Anna-Katerina, Moon, Randall T., Duffield, Jeremy S.

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MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice von Kim, Yeawon, Li, Chuang, Gu, Chenjian, Fang, Yili, Tycksen, Eric, Puri, Anuradhika, Pietka, Terri A., Sivapackiam, Jothilingam, Kidd, Kendrah, Park, Sun-Ji, Johnson, Bryce G., Kmoch, Stanislav, Duffield, Jeremy S., Bleyer, Anthony J., Jackrel, Meredith E., Urano, Fumihiko, Sharma, Vijay, Lindahl, Maria, Chen, Ying Maggie

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A platform to reproducibly evaluate human colon permeability and damage von Marr, Elizabeth E., Mulhern, Thomas J., Welch, Michaela, Keegan, Philip, Caballero-Franco, Celia, Johnson, Bryce G., Kasaian, Marion, Azizgolshani, Hesham, Petrie, Timothy, Charest, Joseph, Wiellette, Elizabeth

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Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6 von Johnson, Bryce G, Ren, Shuyu, Karaca, Gamze, Gomez, Ivan G, Fligny, Cécile, Smith, Benjamin, Ergun, Ayla, Locke, George, Gao, Benbo, Hayes, Sebastian, MacDonnell, Scott, Duffield, Jeremy S

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TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease von Gomez, Ivan G, Roach, Allie M, Nakagawa, Naoki, Amatucci, Aldo, Johnson, Bryce G, Dunn, Kadeshia, Kelly, Mark C, Karaca, Gamze, Zheng, Timothy S, Szak, Suzanne, Peppiatt-Wildman, Claire M, Burkly, Linda C, Duffield, Jeremy S

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A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes von Wang, Ju, Casimiro-Garcia, Agustin, Johnson, Bryce G., Duffen, Jennifer, Cain, Michael, Savary, Leigh, Wang, Stephen, Nambiar, Prashant, Lech, Matthew, Zhao, Shanrong, Xi, Li, Zhan, Yutian, Olson, Jennifer, Stejskal, James A., Lin, Hank, Zhang, Baohong, Martinez, Robert V., Masek-Hammerman, Katherine, Schlerman, Franklin J., Dower, Ken

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Interleukin-1 β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis von Lemos, Dario R, McMurdo, Michael, Karaca, Gamze, Wilflingseder, Julia, Leaf, Irina A, Gupta, Navin, Miyoshi, Tomoya, Susa, Koichiro, Johnson, Bryce G, Soliman, Kirolous, Wang, Guanghai, Morizane, Ryuji, Bonventre, Joseph V, Duffield, Jeremy S

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Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways von Gomez, Ivan G, MacKenna, Deidre A, Johnson, Bryce G, Kaimal, Vivek, Roach, Allie M, Ren, Shuyu, Nakagawa, Naoki, Xin, Cuiyan, Newitt, Rick, Pandya, Shweta, Xia, Tai-He, Liu, Xueqing, Borza, Dorin-Bogdan, Grafals, Monica, Shankland, Stuart J, Himmelfarb, Jonathan, Portilla, Didier, Liu, Shiguang, Chau, B Nelson, Duffield, Jeremy S

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High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy von Dower, Ken, Zhao, Shanrong, Schlerman, Franklin J, Savary, Leigh, Campanholle, Gabriela, Johnson, Bryce G, Xi, Li, Nguyen, Vuong, Zhan, Yutian, Lech, Matthew P, Wang, Ju, Nie, Qing, Karsdal, Morten A, Genovese, Federica, Boucher, Germaine, Brown, Thomas P, Zhang, Baohong, Homer, Bruce L, Martinez, Robert V

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Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier von Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

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Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease von Kim, Yeawon, Wang, Zheyu, Li, Chuang, Kidd, Kendrah, Wang, Yixuan, Johnson, Bryce G., Kmoch, Stanislav, Morrissey, Jeremiah J., Bleyer, Anthony J., Duffield, Jeremy S., Singamaneni, Srikanth, Chen, Ying Maggie

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Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury von Dang, Lan T.H., Aburatani, Takahide, Marsh, Graham A., Johnson, Bryce G., Alimperti, Stella, Yoon, Christine J., Huang, Angela, Szak, Suzanne, Nakagawa, Naoki, Gomez, Ivan, Ren, Shuyu, Read, Sarah K., Sparages, Chris, Aplin, Alfred C., Nicosia, Roberto F., Chen, Chris, Ligresti, Giovanni, Duffield, Jeremy S.

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Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease von Nakagawa, Naoki, Barron, Luke, Gomez, Ivan G, Johnson, Bryce G, Roach, Allie M, Kameoka, Sei, Jack, Richard M, Lupher, Jr, Mark L, Gharib, Sina A, Duffield, Jeremy S

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Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease von Nakagawa, Naoki, Barron, Luke, Gomez, Ivan G., Johnson, Bryce G., Roach, Allie M., Kameoka, Sei, Jack, Richard M., Lupher, Mark L., Gharib, Sina A., Duffield, Jeremy S.

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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Stimulates Autophagy and Restores Mitochondrial Homeostasis to Treat Uromodulin-Associated Nephropathy: TH-OR62 von Li, Chuang, Kim, Yeawon, Gu, Chenjian, Fang, Yili, Tycksen, Eric, Puri, Anuradhika, Pietka, Terri A., Sivapackiam, Jothilingam, Kidd, Kendrah O., Park, Sun-Ji, Johnson, Bryce G., Kmoch, Stanislav, Duffield, Jeremy S., Bleyer, Anthony J., Jackrel, Meredith, Urano, Fumihiko, Sharma, Vijay, Lindahl, Maria, Chen, Ying M.

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Ultrabright Plasmonic-Fluor Nanolabel-Enabled Detection of a Urinary Endoplasmic Reticulum Stress Biomarker in Autosomal Dominant Tubulointerstitial Kidney Disease: PO1351 von Kim, Yeawon, Wang, Zheyu, Li, Chuang, Kidd, Kendrah O., Wang, Yixuan, Johnson, Bryce G., Kmoch, Stanislav, Morrissey, Jeremiah J., Bleyer, Anthony J., Duffield, Jeremy S., Singamaneni, Srikanth, Chen, Ying M.

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Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier von Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

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Discovery of a Novel Autophagy Activator to Treat Autosomal Dominant Tubulointerstitial Kidney Disease: FR-PO343 von Kim, Yeawon, Li, Chuang, Gu, Chenjian, Tycksen, Eric, Park, Sun-Ji, Puri, Anuradhika, Pietka, Terri A., Sivapackiam, Jothilingam, Kidd, Kendrah O., Johnson, Bryce G., Kmoch, Stanislav, Duffield, Jeremy S., Bleyer, Anthony J., Jackrel, Meredith, Urano, Fumihiko, Sharma, Vijay, Lindahl, Maria, Chen, Ying M.

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