Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk von Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A

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In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor von KOBAYASHI, Masanori, YOSHINAGA, Tomokazu, KAWAUCHI-MIKI, Shinobu, TAISHI, Teruhiko, KAWASUJI, Takashi, JOHNS, Brian A, UNDERWOOD, Mark R, GARVEY, Edward P, SATO, Akihiko, FUJIWARA, Tamio, SEKI, Takahiro, WAKASA-MORIMOTO, Chiaki, BROWN, Kevin W, FERRIS, Robert, FOSTER, Scott A, HAZEN, Richard J, MIKI, Shigeru, SUYAMA-KAGITANI, Akemi

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Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection von Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A, Underwood, Mark R, Garvey, Edward P, Sato, Akihiko, Fujiwara, Tamio

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Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Comple... von HIGHTOWER, Kendra E, WANG, Ruolan, SEKI, Takahiro, KOBAYASHI, Masanori, UNDERWOOD, Mark R, DEANDA, Felix, JOHNS, Brian A, WEAVER, Kurt, YINGNIAN SHEN, TOMBERLIN, Ginger H, LUKE CARTER, H, BRODERICK, Timothy, SIGETHY, Scott

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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore von Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio

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The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore von Johns, Brian A., Weatherhead, Jason G., Allen, Scott H., Thompson, James B., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Miller, Wayne H.

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1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position von Johns, Brian A., Weatherhead, Jason G., Allen, Scott H., Thompson, James B., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Miller, Wayne H.

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Advances in two-metal chelation inhibitors of HIV integrase von Johns, Brian A, Svolto, Angilique C

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Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs von Velthuisen, Emile J., Baughman, Todd M., Johns, Brian A., Temelkoff, David P., Weatherhead, Jason G.

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Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors von Akiyama, Toshiyuki, Johns, Brian A., Taoda, Yoshiyuki, Yoshida, Hiroshi, Taishi, Teruhiko, Kawasuji, Takashi, Murai, Hitoshi, Yoshinaga, Tomokazu, Sato, Akihiko, Seki, Takahiro, Koyama, Mikiko, Miki, Shigeru, Kawauchi-Miki, Shinobu, Kagitani-Suyama, Akemi, Fujiwara, Tamio

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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK12... von Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio

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The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults von Underwood, Mark R, Johns, Brian A, Sato, Akihiko, Martin, Jeffrey N, Deeks, Steven G, Fujiwara, Tamio

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A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodefic... von DeJesus, Edwin, Harward, Sara, Jewell, Roxanne C, Johnson, Mark, Dumont, Etienne, Wilches, Viviana, Halliday, Fiona, Talarico, Christine L, Jeffrey, Jerry, Gan, Jianjun, Xu, Jianfeng, Felizarta, Franco, Scribner, Anita, Ramgopal, Moti, Benson, Paul, Johns, Brian A

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Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4- b]pyridin-5(4 H)-ones von Boros, Eric E., Johns, Brian A., Garvey, Edward P., Koble, Cecilia S., Miller, Wayne H.

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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia von Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A

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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias von Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.

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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles von Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Weatherhead, Jason G, Akiyama, Toshiyuki, Taishi, Teruhiko, Taoda, Yoshiyuki, Mikamiyama-Iwata, Minako, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Garvey, Edward P, Fujiwara, Tamio

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Imidazo[1,2- a]pyridines with potent activity against herpesviruses von Gudmundsson, Kristjan S., Johns, Brian A.

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Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation von Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias

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Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo von GOFFINET, Christine, ALLESPACH, Ina, KEPPLER, Oliver T, OBERBREMER, Lena, GOLDEN, Pamela L, FOSTER, Scott A, JOHNS, Brian A, WEATHERHEAD, Jason G, NOVICK, Steven J, CHISWELL, Karen E, GARVEY, Edward P

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