Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi von Nicholson, Donald W, Gervais, François G, Singaraja, Roshni, Xanthoudakis, Steven, Gutekunst, Claire-Anne, Leavitt, Blair R, Metzler, Martina, Hackam, Abigail S, Tam, John, Vaillancourt, John P, Houtzager, Vicky, Rasper, Dita M, Roy, Sophie, Hayden, Michael R

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis von Nicholson, Donald W, Ali, Ambereen, Thornberry, Nancy A, Vaillancourt, John P, Ding, Connie K, Gallant, Michel, Gareau, Yves, Griffin, Patrick R, Labelle, Marc, Lazebnik, Yuri A, Munday, Neil A, Raju, Sayyaparaju M, Smulson, Mark E, Yamin, Ting-Ting, Yu, Violeta L, Miller, Douglas K

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Confinement of caspase-12 proteolytic activity to autoprocessing von Roy, Sophie, Sharom, Jeffrey R, Houde, Caroline, Loisel, Thomas P, Vaillancourt, John P, Shao, Wei, Saleh, Maya, Nicholson, Donald W

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Purification and catalytic properties of human caspase family members von Garcia-Calvo, M, Peterson, E P, Rasper, D M, Vaillancourt, J P, Zamboni, R, Nicholson, D W, Thornberry, N A

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High-frequency transposition for determining antibacterial mode of action von Wang, Hao, Claveau, David, Vaillancourt, John P, Roemer, Terry, Meredith, Timothy C

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics von Méthot, Nathalie, Huang, JingQi, Coulombe, Nathalie, Vaillancourt, John P, Rasper, Dita, Tam, John, Han, Yongxin, Colucci, John, Zamboni, Robert, Xanthoudakis, Steven, Toulmond, Sylvie, Nicholson, Donald W, Roy, Sophie

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms von Nicholson, Donald W, Saleh, Maya, Vaillancourt, John P, Graham, Rona K, Huyck, Matthew, Srinivasula, Srinivasa M, Alnemri, Emad S, Steinberg, Martin H, Nolan, Vikki, Baldwin, Clinton T, Hotchkiss, Richard S, Buchman, Timothy G, Zehnbauer, Barbara A, Hayden, Michael R, Farrer, Lindsay A, Roy, Sophie

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A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation von Méthot, Nathalie, Vaillancourt, John P, Huang, JingQi, Colucci, John, Han, Yongxin, Ménard, Stéphane, Zamboni, Robert, Toulmond, Sylvie, Nicholson, Donald W, Roy, Sophie

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis von Rotonda, Jennifer, Nicholson, Donald W, Fazil, Kimberly M, Gallant, Michel, Gareau, Yves, Labelle, Marc, Peterson, Erin P, Rasper, Dita M, Ruel, Réjean, Vaillancourt, John P, Thornberry, Nancy A, Becker, Joseph W

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Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex von Rasper, D M, Vaillancourt, J P, Hadano, S, Houtzager, V M, Seiden, I, Keen, S L, Tawa, P, Xanthoudakis, S, Nasir, J, Martindale, D, Koop, B F, Peterson, E P, Thornberry, N A, Huang, J, MacPherson, D P, Black, S C, Hornung, F, Lenardo, M J, Hayden, M R, Roy, S, Nicholson, D W

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Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (∗) von Munday, Neil A., Vaillancourt, John P., Ali, Ambereen, Casano, Francesca J., Miller, Douglas K., Molineaux, Susan M., Yamin, Ting-Ting, Yu, Violeta L., Nicholson, Donald W.

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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors von Han, Yongxin, Giroux, André, Grimm, Erich L., Aspiotis, Renée, Francoeur, Sébastien, Bayly, Christopher I., Mckay, Daniel J., Roy, Sophie, Xanthoudakis, Steve, Vaillancourt, John P., Rasper, Dita M., Tam, John, Tawa, Paul, Thornberry, Nancy A., Paterson, Erin P., Garcia-Calvo, Margarita, Becker, Joseph W., Rotonda, Jennifer, Nicholson, Donald W., Zamboni, Robert J.

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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones von Isabel, Elise, Aspiotis, Renee, Black, W. Cameron, Colucci, John, Fortin, Réjean, Giroux, André, Grimm, Erich L., Han, Yongxin, Mellon, Christophe, Nicholson, Donald W., Rasper, Dita M., Renaud, Johanne, Roy, Sophie, Tam, John, Tawa, Paul, Vaillancourt, John P., Xanthoudakis, Steven, Zamboni, Robert J.

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Nicotinyl aspartyl ketones as inhibitors of caspase-3 von Isabel, Elise, Black, W.Cameron, Bayly, Christopher I, Grimm, Erich L, Janes, Marc K, McKay, Daniel J, Nicholson, Donald W, Rasper, Dita M, Renaud, Johanne, Roy, Sophie, Tam, John, Thornberry, Nancy A, Vaillancourt, John P, Xanthoudakis, Steven, Zamboni, Robert

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis von Thornberry, N A, Rano, T A, Peterson, E P, Rasper, D M, Timkey, T, Garcia-Calvo, M, Houtzager, V M, Nordstrom, P A, Roy, S, Vaillancourt, J P, Chapman, K T, Nicholson, D W

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Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors von MELLON, Christophe, ASPIOTIS, Reneé, RASPER, Dita M, ROY, Sophie, TAM, John, THORNBERRY, Nancy A, VAILLANCOURT, John P, XANTHOUDAKIS, Steven, ZAMBONI, Robert, BLACK, Cameron W, BAYLY, Christopher I, GRIMM, Erich L, GIROUX, André, YONGXIN HAN, ISABEL, Elise, MCKAY, Daniel J, NICHOLSON, Donald W

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Solid phase synthesis of selective caspase-3 peptide inhibitors von GRIMM, Erich L, ROY, Bruno, VAILLANCOURT, John P, XANTHOUDAKIS, Steven, ZAMBONI, Robert J, ASPIOTIS, Renee, BAYLY, Christopher I, NICHOLSON, Donald W, RASPER, Dita M, RENAUD, Johanne, ROY, Sophie, TAM, John, TAWA, Paul

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Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation von Gervais, François G., Xu, Daigen, Robertson, George S., Vaillancourt, John P., Zhu, Yanxia, Huang, JingQi, LeBlanc, Andréa, Smith, David, Rigby, Michael, Shearman, Mark S., Clarke, Earl E., Zheng, Hui, Van Der Ploeg, Leonardus H.T., Ruffolo, Salvatore C., Thornberry, Nancy A., Xanthoudakis, Steve, Zamboni, Robert J., Roy, Sophie, Nicholson, Donald W.

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Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3 von Hadano , † , Jamal Nasir, Shinji, Nichol, Kerrie, Rasper, Dita M., Vaillancourt, John P., Sherer, Stephen W., Beatty, Barbara G., Ikeda †, †† , Donald, Joh-E, Hayden, Michael R.

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A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B von Thornberry, Nancy A., Rano, Thomas A., Peterson, Erin P., Rasper, Dita M., Timkey, Tracy, Garcia-Calvo, Margarita, Houtzager, Vicky M., Nordstrom, Penny A., Roy, Sophie, Vaillancourt, John P., Chapman, Kevin T., Nicholson, Donald W.

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