Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection von Link, John O., Taylor, James G., Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Keller, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C.

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Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein von Lawitz, Eric J, Dvory-Sobol, Hadas, Doehle, Brian P, Worth, Angela S, McNally, John, Brainard, Diana M, Link, John O, Miller, Michael D, Mo, Hongmei

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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi von Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.

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Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent von Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M, Kirschberg, Thorsten, Kato, Darryl, Link, John O, Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman

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Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa von Link, John O., Taylor, James G., Trejo-Martin, Alejandra, Kato, Darryl, Katana, Ashley A., Krygowski, Evan S., Yang, Zheng-Yu, Zipfel, Sheila, Cottell, Jeromy J., Bacon, Elizabeth M., Tran, Chinh V., Yang, Cheng Y., Wang, Yujin, Wang, Kelly W., Zhao, Guangyu, Cheng, Guofeng, Tian, Yang, Gong, Ruoyu, Lee, Yu-Jen, Yu, Mei, Gorman, Eric, Mogalian, Erik, Perry, Jason K.

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Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection von Link, John O, Taylor, James G, Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Kellar, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C

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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model von Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

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A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C von Lawitz, Eric J, Gruener, Daniel, Hill, John M, Marbury, Thomas, Moorehead, Lisa, Mathias, Anita, Cheng, Guofeng, Link, John O, Wong, Kelly A, Mo, Hongmei, McHutchison, John G, Brainard, Diana M

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In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir von Cheng, Guofeng, Tian, Yang, Doehle, Brian, Peng, Betty, Corsa, Amoreena, Lee, Yu-Jen, Gong, Ruoyu, Yu, Mei, Han, Bin, Xu, Simin, Dvory-Sobol, Hadas, Perron, Michel, Xu, Yili, Mo, Hongmei, Pagratis, Nikos, Link, John O, Delaney, William

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Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873 von Kato, Darryl, Choy, Regina Wai-Yan, Canales, Eda, Dick, Ryan A., Lake, April D., Shapiro, Nathan D., Chin, Elbert, Li, Jiayao, Zhang, Jennifer R., Wu, Qiaoyin, Saito, Roland D., Metobo, Sammy, Aktoudianakis, Evangelos, Schroeder, Scott D., Yang, Zheng-Yu, Glatt, Dylan M., Balsitis, Scott, Gamelin, Lindsay, Yu, Mei, Cheng, Guofeng, Delaney, William E., Link, John O.

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A general, catalytic, and enantioselective synthesis of .alpha.-amino acids von Corey, E. J, Link, John O

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539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans von Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C

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A catalytic enantioselective synthesis of denopamine, a useful drug for congestive heart failure von Corey, E. J, Link, John O

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Clinical targeting of HIV capsid protein with a long-acting small molecule von Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas

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Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent von Smith, David B, Waltos, Ann Marie, Loughhead, David G, Weikert, Robert J, Morgans, David J, Rohloff, John C, Link, John O, Zhu, Rong-rong

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Trapping of an IMP Dehydrogenase−Substrate Covalent Intermediate by Mycophenolic Acid von Link, John O, Straub, Kenneth

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The Discovery of Ledipasvir (GS-5885): The Potent Once-Daily Oral HCV NS5A Inhibitor in the Single-Tablet Regimen Harvoni von Link, John O.

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The Discovery of Velpatasvir (GS-5816): The Potent Pan-Genotypic Once-Daily Oral HCV NS5A Inhibitor in the Single-Tablet Regimens Epclusa and Vosevi von Link, John O.

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A new chiral catalyst for the enantioselective synthesis of secondary alcohols and deuterated primary alcohols by carbonyl reduction von Corey, E.J., Link, John O.

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A mechanistic and structural analysis of the basis for high enantioselectivity in the oxazaborolidine-catalyzed reduction of trihalomethyl ketones by catecholborane von Corey, E.J., Link, John O., Bakshi, Raman K.

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