Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS von Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro

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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy von Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika

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Peptide Inhibitors of West Nile NS3 Protease:  SAR Study of Tetrapeptide Aldehyde Inhibitors von Knox, John E, Ma, Ngai Ling, Yin, Zheng, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K. R, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash G, Keller, Thomas H

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors von Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.

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Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography von Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu

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Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis von Kurabachew, Mekonnen, Lu, Stephen H. J., Krastel, Philipp, Schmitt, Esther K., Suresh, Bangalore L., Goh, Anne, Knox, John E., Ma, Ngai Ling, Jiricek, Jan, Beer, David, Cynamon, Michael, Petersen, Frank, Dartois, Veronique, Keller, Thomas, Dick, Thomas, Sambandamurthy, Vasan K.

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Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824 von XIAOJIN LI, MANJUNATHA, Ujjini H, GOODWIN, Michael B, KNOX, John E, LIPINSKI, Christopher A, KELLER, Thomas H, BARRY, Clifton E, DOWD, Cynthia S

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Chemical failure modes of AlQ3-based OLEDs : AlQ3 hydrolysis von KNOX, John E, HALLS, Mathew D, HRATCHIAN, Hrant P, SCHLEGEL, H. Bernhard

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Experimental and Theoretical Study of the Coordination of 1,2,4-Triazolato, Tetrazolato, and Pentazolato Ligands to the [K(18-crown-6)]+ Fragment von Kobrsi, Issam, Zheng, Wenjun, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H

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Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors von Yin, Zheng, Patel, Sejal J., Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K.R., Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Knox, John E., Ma, Ngai Ling, Ehrhardt, Claus, Lim, Siew Pheng, Vasudevan, Subhash G., Keller, Thomas H.

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Yellow fever virus NS3 protease: peptide-inhibition studies von Lohr, Kristina, Knox, John E, Phong, Wai Yee, Ma, Ngai Ling, Yin, Zheng, Sampath, Aruna, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Rao, K. R. Ranga, Wang, Gang, Vasudevan, Subhash G, Keller, Thomas H, Lim, Siew Pheng

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Synthesis, Structure, and Properties of Magnesocene Amine Adducts. Structural Distortions Arising from N−H···C5H5 - Hydrogen Bonding and Molecular Orbital Calculations Thereof von Xia, Aibing, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H

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Weak Carbon−Hydrogen−Nitrogen Interactions Affect the Heterocyclic Ligand Bonding Modes in Barium Complexes Containing η2-Tetrazolato and η2-Pentazolato Ligands von Kobrsi, Issam, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H

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Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibiti... von Nichols, Robert J., Cregg, Jim, Schulze, Christopher J., Wang, Zhican, Yang, Kevin, Jiang, Jingjing, Whalen, Daniel M., Hansen, Rich, Garrenton, Lindsay S., Bermingham, Alun, Knox, John E., Choy, Tiffany, Reyes, Denise, Rios, Mayra, Seamon, Kyle, Longhi, Michael, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Smith, Jacqueline A. M.

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Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical mode... von Koltun, Elena, Cregg, Jim, Rice, Meghan A., Whalen, Dan M., Freilich, Rebecca, Jiang, Jingjing, Hansen, Richard, Bermingham, Alun, Knox, John E., Dinglasan, Jay, Seamon, Kyle, Blaj, Cristina, Chang, Stephanie S., Liu, Yang, Huang, Jun, Chou, Kang-Jye, McDowell, Laura, Lee, Bianca J., Wildes, David, Wang, Zhengping, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.

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Synthesis, Structure, Bridge−Terminal Exchange Kinetics, and Molecular Orbital Calculations of Pyrazolate-Bridged Digallium Complexes Containing Bridging Phenyl Groups von Sirimanne, Chatu T, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H

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Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1... von Buckl, Andreas, Quintana, Elsa, Lee, Grace J., Shifrin, Nataliya, Zhong, Mengqi, Garrenton, Lindsay S., Montgomery, David C., Stahlhut, Carlos, Zhao, Frances, Whalen, Dan M., Thompson, Severin K., Tambo-ong, Arlyn, Gliedt, Micah, Knox, John E., Cregg, James J., Aay, Naing, Choi, Jong, Nguyen, Bao, Tripathi, Atti, Zhao, Ruiping, Saldajeno-Concar, Mae, Marquez, Abby, Hsieh, Daphne, McDowell, Laura L., Koltun, Elena S., Bermingham, Alun, Wildes, David, Singh, Mallika, Wang, Zhengping, Hansen, Richard, Smith, Jan A., Gill, Adrian L.

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Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergiz... von Menard, Marie J., Chow, Christopher, Chen, Kevin, Blaj, Cristina, Shifrin, Nataliya Tovbis, Courtney, Haley, Nasholm, Nicole M., Pham, Anna, Kumamoto, Alice, Ganesh, Swetha, Evans, James W., Lawrence, Lindsey, Vonmelchert, Brian, Kwok-Parkhill, Amy C., Jiang, Jingjing, Knox, John E., Smith, Jacqueline, Quintana, Elsa

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Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRA... von Jiang, Lingyan, Menard, Marie, Weller, Caroline, Wang, Zhican, Burnett, Les, Aronchik, Ida, Steele, Shelby, Flagella, Mike, Zhao, Ruiping, Evans, James W W., Chin, Shook, Chou, Kang-Jye, Mu, Yunming, Longhi, Michael, McDowell, Laura, Knox, John E., Gill, Adrian, Smith, Jacqueline A., Singh, Mallika, Quintana, Elsa, Jiang, Jingjing

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Abstract 3596: RM-036, a first-in-class, orally-bioavailable, Tri-Complex covalent KRASG12D(ON) inhibitor, drives profound anti-tumor activity in KRASG12D mutant tumor models von Knox, John E., Jiang, Jingjing, Burnett, G. Leslie, Liu, Yang, Weller, Caroline E., Wang, Zhican, McDowell, Laura, Steele, Shelby L., Chin, Shook, Chou, Kang Jye, Wang, Fang, Zhong, Mengqi, Koltun, Elena S., Wildes, David, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.

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