SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression von Hou, Guojun, Harley, Isaac T. W., Lu, Xiaoming, Zhou, Tian, Xu, Ning, Yao, Chao, Qin, Yuting, Ouyang, Ye, Ma, Jianyang, Zhu, Xinyi, Yu, Xiang, Xu, Hong, Dai, Dai, Ding, Huihua, Yin, Zhihua, Ye, Zhizhong, Deng, Jun, Zhou, Mi, Tang, Yuanjia, Namjou, Bahram, Guo, Ya, Weirauch, Matthew T., Kottyan, Leah C., Harley, John B., Shen, Nan

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Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies von Kelly, Jennifer A, Harley, Isaac T. W, Kaufman, Kenneth M, Langefeld, Carl D, Harley, John B

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Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification von Munroe, Melissa E, Lu, Rufei, Zhao, Yan D, Fife, Dustin A, Robertson, Julie M, Guthridge, Joel M, Niewold, Timothy B, Tsokos, George C, Keith, Michael P, Harley, John B, James, Judith A

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Whole‐Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis von Kaufman, Kenneth M., Linghu, Bolan, Szustakowski, Joseph D., Husami, Ammar, Yang, Fan, Zhang, Kejian, Filipovich, Alexandra H., Fall, Ndate, Harley, John B., Nirmala, N. R., Grom, Alexei A.

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Global discovery of lupus genetic risk variant allelic enhancer activity von Lu, Xiaoming, Chen, Xiaoting, Forney, Carmy, Donmez, Omer, Miller, Daniel, Parameswaran, Sreeja, Hong, Ted, Huang, Yongbo, Pujato, Mario, Cazares, Tareian, Miraldi, Emily R., Ray, John P., de Boer, Carl G., Harley, John B., Weirauch, Matthew T., Kottyan, Leah C.

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Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis von Harris, Valerie M, Koelsch, Kristi A, Kurien, Biji T, Harley, Isaac T W, Wren, Jonathan D, Harley, John B, Scofield, R Hal

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MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis von Pan, Wen, Zhu, Shu, Dai, Dai, Liu, Zheng, Li, Dan, Li, Bin, Gagliani, Nicola, Zheng, Yunjiang, Tang, Yuanjia, Weirauch, Matthew T., Chen, Xiaoting, Zhu, Wei, Wang, Yue, Chen, Bo, Qian, Youcun, Chen, Yingxuan, Fang, Jingyuan, Herbst, Ronald, Richman, Laura, Jallal, Bahija, Harley, John B., Flavell, Richard A., Yao, Yihong, Shen, Nan

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Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks von Pelikan, Richard C., Kelly, Jennifer A., Fu, Yao, Lareau, Caleb A., Tessneer, Kandice L., Wiley, Graham B., Wiley, Mandi M., Glenn, Stuart B., Harley, John B., Guthridge, Joel M., James, Judith A., Aryee, Martin J., Montgomery, Courtney, Gaffney, Patrick M.

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Identification of Four Novel Loci in Asthma in European American and African American Populations von Almoguera, Berta, Vazquez, Lyam, Mentch, Frank, Connolly, John, Pacheco, Jennifer A, Sundaresan, Agnes S, Peissig, Peggy L, Linneman, James G, McCarty, Catherine A, Crosslin, David, Carrell, David S, Lingren, Todd, Namjou-Khales, Bahram, Harley, John B, Larson, Eric, Jarvik, Gail P, Brilliant, Murray, Williams, Marc S, Kullo, Iftikhar J, Hysinger, Erik B, Sleiman, Patrick M A, Hakonarson, Hakon

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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus von Arbuckle, Melissa R, McClain, Micah T, Rubertone, Mark V, Scofield, R. Hal, Dennis, Gregory J, James, Judith A, Harley, John B

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T-bet + CD11c + B cells are critical for antichromatin immunoglobulin G production in the development of lupus von Liu, Ya, Zhou, Shiyu, Qian, Jie, Wang, Yan, Yu, Xiang, Dai, Dai, Dai, Min, Wu, Lingling, Liao, Zhuojun, Xue, Zhixin, Wang, Jiehua, Hou, Goujun, Ma, Jianyang, Harley, John B, Tang, Yuanjia, Shen, Nan

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In Vivo Therapeutic Success of MicroRNA‐155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage von Zhou, Shiyu, Wang, Yan, Meng, Yao, Xiao, Chunyuan, Liu, Zheng, Brohawn, Philip, Higgs, Brandon W., Jallal, Bahija, Jia, Qian, Qu, Bo, Huang, Xinfang, Tang, Yuanjia, Yao, Yihong, Harley, John B., Shen, Nan

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Identification of unique microRNA signature associated with lupus nephritis von Te, Jeannie L, Dozmorov, Igor M, Guthridge, Joel M, Nguyen, Kim L, Cavett, Joshua W, Kelly, Jennifer A, Bruner, Gail R, Harley, John B, Ojwang, Joshua O

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A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies von Laurynenka, Viktoryia, Ding, Lili, Kaufman, Kenneth M, James, Judith A, Harley, John B

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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery von Zhou, Tian, Zhu, Xinyi, Ye, Zhizhong, Wang, Yong-Fei, Yao, Chao, Xu, Ning, Zhou, Mi, Ma, Jianyang, Qin, Yuting, Shen, Yiwei, Tang, Yuanjia, Yin, Zhihua, Xu, Hong, Zhang, Yutong, Zang, Xiaoli, Ding, Huihua, Yang, Wanling, Guo, Ya, Harley, John B., Namjou, Bahram, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T., Hou, Guojun, Shen, Nan

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Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis von Sinner, Debora I, Carey, Brenna, Zgherea, Daniela, Kaufman, K M, Leesman, Lauren, Wood, Robert E, Rutter, Michael J, de Alarcon, Alessandro, Elluru, Ravindhra G, Harley, John B, Whitsett, Jeffrey A, Trapnell, Bruce C

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Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility von Adrianto, Indra, Lin, Chee Paul, Hale, Jessica J, Levin, Albert M, Datta, Indrani, Parker, Ryan, Adler, Adam, Kelly, Jennifer A, Kaufman, Kenneth M, Lessard, Christopher J, Moser, Kathy L, Kimberly, Robert P, Harley, John B, Iannuzzi, Michael C, Rybicki, Benjamin A, Montgomery, Courtney G

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Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways von Vaughn, Samuel E., Kottyan, Leah C., Munroe, Melissa E., Harley, John B.

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Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase von Jacob, Chaim O, Eisenstein, Miriam, Dinauer, Mary C, Ming, Wenyu, Liu, Qiang, John, Sutha, Quismorio, Francesco P., Jr, Reiff, Andreas, Myones, Barry L, Kaufman, Kenneth M, McCurdy, Deborah, Harley, John B, Silverman, Earl, Kimberly, Robert P, Vyse, Timothy J, Gaffney, Patrick M, Moser, Kathy L, Klein-Gitelman, Marisa, Wagner-Weiner, Linda, Langefeld, Carl D, Armstrong, Don L, Zidovetzki, Raphael

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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry von James, Judith A, McClain, Micah T, Heinlen, Latisha D, Dennis, Gregory J, Roebuck, Jon, Harley, John B

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