Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium von Stange, Daniel E., Koo, Bon-Kyoung, Huch, Meritxell, Sibbel, Greg, Basak, Onur, Lyubimova, Anna, Kujala, Pekka, Bartfeld, Sina, Koster, Jan, Geahlen, Jessica H., Peters, Peter J., van Es, Johan H., van de Wetering, Marc, Mills, Jason C., Clevers, Hans

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Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer von Dow, Lukas E., O’Rourke, Kevin P., Simon, Janelle, Tschaharganeh, Darjus F., van Es, Johan H., Clevers, Hans, Lowe, Scott W.

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Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids von Lõhmussaar, Kadi, Kopper, Oded, Korving, Jeroen, Begthel, Harry, Vreuls, Celien P. H., van Es, Johan H., Clevers, Hans

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Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche von Chakrabarti, Rumela, Celià-Terrassa, Toni, Kumar, Sushil, Hang, Xiang, Wei, Yong, Choudhury, Abrar, Hwang, Julie, Peng, Jia, Nixon, Briana, Grady, John J, DeCoste, Christina, Gao, Jie, van Es, Johan H, Li, Ming O, Aifantis, Iannis, Clevers, Hans, Kang, Yibin

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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand von Boj, Sylvia F., van Es, Johan H., Huch, Meritxell, Li, Vivian S.W., José, Anabel, Hatzis, Pantelis, Mokry, Michal, Haegebarth, Andrea, van den Born, Maaike, Chambon, Pierre, Voshol, Peter, Dor, Yuval, Cuppen, Edwin, Fillat, Cristina, Clevers, Hans

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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas von Schepers, Arnout G., Snippert, Hugo J., Stange, Daniel E., van den Born, Maaike, van Es, Johan H., van de Wetering, Marc, Clevers, Hans

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Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition von Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.

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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters von Tetteh, Paul W., Basak, Onur, Farin, Henner F., Wiebrands, Kay, Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, de Sauvage, Frederic, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

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Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids von Artegiani, Benedetta, van Voorthuijsen, Lisa, Lindeboom, Rik G.H., Seinstra, Daniëlle, Heo, Inha, Tapia, Pablo, López-Iglesias, Carmen, Postrach, Daniel, Dayton, Talya, Oka, Rurika, Hu, Huili, van Boxtel, Ruben, van Es, Johan H., Offerhaus, Johan, Peters, Peter J., van Rheenen, Jacco, Vermeulen, Michiel, Clevers, Hans

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A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche von Artegiani, Benedetta, Lyubimova, Anna, Muraro, Mauro, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

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The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis von Sylva, Marc, Li, Vivian S W, Buffing, Anita A A, van Es, Johan H, van den Born, Maaike, van der Velden, Saskia, Gunst, Quinn, Koolstra, Jan Harm, Moorman, Antoon F M, Clevers, Hans, van den Hoff, Maurice J B

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium von Sato, Toshiro, Stange, Daniel E, Ferrante, Marc, Vries, Robert G.J, van Es, Johan H, van den Brink, Stieneke, van Houdt, Winan J, Pronk, Apollo, van Gorp, Joost, Siersema, Peter D, Clevers, Hans

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Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia von Koo, Bon-Kyoung, Johan H. van Es, Maaike van den Born, Hans Clevers

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Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy von Driehuis, Else, Kolders, Sigrid, Spelier, Sacha, Lõhmussaar, Kadi, Willems, Stefan M, Devriese, Lot A, de Bree, Remco, de Ruiter, Emma J, Korving, Jeroen, Begthel, Harry, van Es, Johan H, Geurts, Veerle, He, Gui-Wei, van Jaarsveld, Richard H, Oka, Rurika, Muraro, Mauro J, Vivié, Judith, Zandvliet, Maurice M J M, Hendrickx, Antoni P A, Iakobachvili, Nino, Sridevi, Priya, Kranenburg, Onno, van Boxtel, Ruben, Kops, Geert J P L, Tuveson, David A, Peters, Peter J, van Oudenaarden, Alexander, Clevers, Hans

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration von Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., Li, Vivian S. W., van de Wetering, Marc, Sato, Toshiro, Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Vries, Robert G., Grompe, Markus, Clevers, Hans

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Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon von Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans

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Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion von Snippert, Hugo J., Schepers, Arnout G., van Es, Johan H., Simons, Benjamin D., Clevers, Hans

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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage von van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Yee Nee, Annie Ng, Gregorieff, Alex, Sasaki, Nobuo, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C. M., Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans

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Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells von Snippert, Hugo J., van der Flier, Laurens G., Sato, Toshiro, van Es, Johan H., van den Born, Maaike, Kroon-Veenboer, Carla, Barker, Nick, Klein, Allon M., van Rheenen, Jacco, Simons, Benjamin D., Clevers, Hans

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Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion von van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans

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