The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches von Joerger, Andreas C, Fersht, Alan R

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Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy von Wanior, Marek, Krämer, Andreas, Knapp, Stefan, Joerger, Andreas C.

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TP53: the unluckiest of genes? von Joerger, Andreas C, Stiewe, Thorsten, Soussi, Thierry

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Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology von Wilcken, Rainer, Zimmermann, Markus O, Lange, Andreas, Joerger, Andreas C, Boeckler, Frank M

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Structural biology of the tumor suppressor p53 von Joerger, Andreas C, Fersht, Alan R

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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases von Uversky, Vladimir N, Davé, Vrushank, Iakoucheva, Lilia M, Malaney, Prerna, Metallo, Steven J, Pathak, Ravi Ramesh, Joerger, Andreas C

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2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells von Bauer, Matthias R., Joerger, Andreas C., Fersht, Alan R.

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Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition von Joerger, Andreas C.

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Small molecule induced reactivation of mutant p53 in cancer cells von Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C, Chuckowree, Irina S, Amin, Jahangir, Spencer, John, Fersht, Alan R

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The tumor suppressor p53: from structures to drug discovery von Joerger, Andreas C, Fersht, Alan R

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Design of a molecular support for cryo-EM structure determination von Martin, Thomas G., Bharat, Tanmay A. M., Joerger, Andreas C., Bai, Xiao-chen, Praetorius, Florian, Fersht, Alan R., Dietz, Hendrik, Scheres, Sjors H. W.

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Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators von Balourdas, Dimitrios-Ilias, Markl, Anja M., Krämer, Andreas, Settanni, Giovanni, Joerger, Andreas C.

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Tracing the Evolution of the p53 Tetramerization Domain von Joerger, Andreas C., Wilcken, Rainer, Andreeva, Antonina

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Structural Basis for Understanding Oncogenic p53 Mutations and Designing Rescue Drugs von Joerger, Andreas C., Ang, Hwee Ching, Fersht, Alan R.

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug von Boeckler, Frank M, Joerger, Andreas C, Jaggi, Gaurav, Rutherford, Trevor J, Veprintsev, Dmitry B, Fersht, Alan R

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Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors von Tesch, Roberta, Rak, Marcel, Raab, Monika, Berger, Lena M, Kronenberger, Thales, Joerger, Andreas C, Berger, Benedict-Tilman, Abdi, Ismahan, Hanke, Thomas, Poso, Antti, Strebhardt, Klaus, Sanhaji, Mourad, Knapp, Stefan

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53 von Wilcken, Rainer, Liu, Xiangrui, Zimmermann, Markus O., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.

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Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis von Wanior, Marek, Preuss, Franziska, Ni, Xiaomin, Krämer, Andreas, Mathea, Sebastian, Göbel, Tamara, Heidenreich, David, Simonyi, Svenja, Kahnt, Astrid S, Joerger, Andreas C, Knapp, Stefan

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Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53 von Joerger, Andreas C., Bauer, Matthias R., Wilcken, Rainer, Baud, Matthias G.J., Harbrecht, Hannes, Exner, Thomas E., Boeckler, Frank M., Spencer, John, Fersht, Alan R.

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Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm von Bauer, Matthias R, Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N, Ni, Xiaomin, Khan Tareque, Raysa, Fersht, Alan R, Spencer, John, Joerger, Andreas C

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