UM Cure 2020: New therapies for uveal melanoma von Roman-Roman, Sergio, Stern, Marc-Henri, Alsafadi, Samar, Jager, Martine J., Dogrusöz, Mehmet, Coupland, Sarah E., Mione, Maria Caterina, Anelli, Viviana, Precazzini, Francesca, Mobuchon, Lenha, Nemati, Fariba, Decaudin, Didier, Rodrigues, Manuel, Lantz, Olivier, Barnhill, Raymond, Piperno-Neumann, Sophie, Cassoux, Nathalie, Desjardins, Laurence, Gezgin, Gulçin, Wierenga, Annemijn, Jochemsen, Aart J., Glinkina, Kseniya A., van der Velden, Pieter A., Nell, Rogier J., Groenewoud, Arwin, Snaar-Jagalska, Marais, Richard, Mahal, Katharina, Hascoet, Pauline, Kalirai, Helen, Elas, Martyna, Romanowska-Dixon, Bozena, Ruijtenbeek, van den Heuvel, Dianne, Houkes, Liesbeth, Lebel-Binay, Sophie, Prestat, Antoine, Sengenés, Jennifer, Ryll, Bettina, Valente, André, Vinolo, Emilie

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Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma von Christodoulou, Eirini, Rashid, Mamunur, Pacini, Clare, Droop, Alastair, Robertson, Holly, Groningen, Tim van, Teunisse, Amina F. A. S., Iorio, Francesco, Jochemsen, Aart G., Adams, David J., Doorn, Remco van

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Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines von Hollestelle, Antoinette, Nagel, Jord H. A, Smid, Marcel, Lam, Suzanne, Elstrodt, Fons, Wasielewski, Marijke, Ng, Ser Sue, French, Pim J, Peeters, Justine K, Rozendaal, Marieke J, Riaz, Muhammad, Koopman, Daphne G, ten Hagen, Timo L. M, de Leeuw, Bertie H. C. G. M, Zwarthoff, Ellen C, Teunisse, Amina, van der Spek, Peter J, Klijn, Jan G. M, Dinjens, Winand N. M, Ethier, Stephen P, Clevers, Hans, Jochemsen, Aart G, den Bakker, Michael A, Foekens, John A, Martens, John W. M, Schutte, Mieke

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Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy von Cao, Jinfeng, Heijkants, Renier C, Jochemsen, Aart G, Dogrusöz, Mehmet, de Lange, Mark J, van der Velden, Pieter A, van der Burg, Sjoerd H, Jager, Martine J, Verdijk, Robert M

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Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma von Glinkina, Kseniya, Nemati, Fariba, Teunisse, Amina F A S, Gelmi, Maria Chiara, Etienne, Vesnie, Kuipers, Muriel J, Alsafadi, Samar, Jager, Martine J, Decaudin, Didier, Jochemsen, Aart G

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So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020 von Rodrigues, Manuel, Koning, Leanne de, Coupland, Sarah E, Jochemsen, Aart G, Marais, Richard, Stern, Marc-Henri, Valente, André, Barnhill, Raymond, Cassoux, Nathalie, Evans, Andrew, Galloway, Iain, Jager, Martine J, Kapiteijn, Ellen, Romanowska-Dixon, Bozena, Ryll, Bettina, Roman-Roman, Sergio, Piperno-Neumann, Sophie

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MDM4 is a key therapeutic target in cutaneous melanoma von Gembarska, Agnieszka, Luciani, Flavie, Fedele, Clare, Russell, Elisabeth A, Dewaele, Michael, Villar, Stéphanie, Zwolinska, Aleksandra, Haupt, Sue, de Lange, Job, Yip, Dana, Goydos, James, Haigh, Jody J, Haupt, Ygal, Larue, Lionel, Jochemsen, Aart, Shi, Hubing, Moriceau, Gatien, Lo, Roger S, Ghanem, Ghanem, Shackleton, Mark, Bernal, Federico, Marine, Jean-Christophe

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Mdmx as an essential regulator of p53 activity von Marine, Jean-Christophe, Jochemsen, Aart G.

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Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery von Yin, Jie, Zhao, Gangyin, Kalirai, Helen, Coupland, Sarah E, Jochemsen, Aart G, Forn-Cuní, Gabriel, Wierenga, Annemijn P A, Jager, Martine J, Snaar-Jagalska, B Ewa, Groenewoud, Arwin

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Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity von Danovi, Davide, Meulmeester, Erik, Pasini, Diego, Migliorini, Domenico, Capra, Maria, Frenk, Ruth, de Graaf, Petra, Francoz, Sarah, Gasparini, Patrizia, Gobbi, Alberto, Helin, Kristian, Pelicci, Pier Giuseppe, Jochemsen, Aart G., Marine, Jean-Christophe

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WT1 proteins: functions in growth and differentiation von Scharnhorst, Volkher, van der Eb, Alex J, Jochemsen, Aart G

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Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53 von Gu, Jijie, Kawai, Hidehiko, Nie, Linghu, Kitao, Hiroyuki, Wiederschain, Dmitri, Jochemsen, Aart G., Parant, John, Lozano, Guillermina, Yuan, Zhi-Min

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Modeling of human uveal melanoma in zebrafish xenograft embryos von van der Ent, Wietske, Burrello, Claudia, Teunisse, Amina F A S, Ksander, Bruce R, van der Velden, Pieter A, Jager, Martine J, Jochemsen, Aart G, Snaar-Jagalska, B Ewa

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 von Parant, John, Chavez-Reyes, Arturo, Little, Natalie A., Yan, Wen, Reinke, Valerie, Jochemsen, Aart G., Lozano, Guillermina

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Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target von Groenewoud, Arwin, Yin, Jie, Gelmi, Maria Chiara, Alsafadi, Samar, Nemati, Fariba, Decaudin, Didier, Roman-Roman, Sergio, Kalirai, Helen, Coupland, Sarah E., Jochemsen, Aart G., Jager, Martine J., Engel, Felix B., Snaar-Jagalska, B. E.

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HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target von Souri, Zahra, Wierenga, Annemijn P A, Mulder, Arend, Jochemsen, Aart G, Jager, Martine J

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HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma von Souri, Zahra, Jochemsen, Aart G, Versluis, Mieke, Wierenga, Annemijn P A, Nemati, Fariba, van der Velden, Pieter A, Kroes, Wilma G M, Verdijk, Robert M, Luyten, Gregorius P M, Jager, Martine J

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Phosphorylation of Hdmx Mediates Its Hdm2- and ATM-Dependent Degradation in Response to DNA Damage von Pereg, Yaron, Shkedy, Dganit, de Graaf, Petra, Meulmeester, Erik, Edelson-Averbukh, Marina, Salek, Mogjiborahman, Biton, Sharon, Amina F. A. S. Teunisse, Lehmann, Wolf D., Jochemsen, Aart G., Shiloh, Yosef, Elledge, Stephen J.

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Hdmx Protein Stability Is Regulated by the Ubiquitin Ligase Activity of Mdm2 von de Graaf, Petra, Little, Natalie A., Ramos, Yolande F.M., Meulmeester, Erik, Letteboer, Stef J.F., Jochemsen, Aart G.

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Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target von Cao, Jinfeng, Pontes, Kelly CS, Heijkants, Renier C, Brouwer, Niels J, Groenewoud, Arwin, Jordanova, Ekaterina S, Marinkovic, Marina, van Duinen, Sjoerd, Teunisse, Amina FAS, Verdijk, Robert M, Snaar‐Jagalska, Ewa, Jochemsen, Aart G, Jager, Martine J

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