ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer von Van Schaeybroeck, Sandra, Kalimutho, Murugan, Dunne, Philip D., Carson, Robbie, Allen, Wendy, Jithesh, Puthen V., Redmond, Keara L., Sasazuki, Takehiko, Shirasawa, Senji, Blayney, Jaine, Michieli, Paolo, Fenning, Cathy, Lenz, Heinz-Josef, Lawler, Mark, Longley, Daniel B., Johnston, Patrick G.

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Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma von Barbone, Dario, Van Dam, Loes, Follo, Carlo, Jithesh, Puthen V, Zhang, Shu-Dong, Richards, William G, Bueno, Raphael, Fennell, Dean A, Broaddus, V Courtney

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Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer von Grills, Claire, Jithesh, Puthen V, Blayney, Jaine, Zhang, Shu-Dong, Fennell, Dean A

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Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing von Hasan, Mohammad R, Rawat, Arun, Tang, Patrick, Jithesh, Puthen V, Thomas, Eva, Tan, Rusung, Tilley, Peter

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Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer von STEVENSON, Leanne, ALLEN, Wendy L, TURKINGTON, Richard, JITHESH, Puthen V, PROUTSKI, Irina, STEWART, Gail, LENZ, Heinz-Josef, VAN SCHAEYBROECK, Sandra, LONGLEY, Daniel B, JOHNSTON, Patrick G

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Integrated omics profiling reveals novel patterns of epigenetic programming in cancer-associated myofibroblasts von Najgebauer, Hanna, Liloglou, Triantafillos, Jithesh, Puthen V, Giger, Olivier T, Varro, Andrea, Sanderson, Christopher M

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AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3 von Habib, Tanwir, Sadoun, Ameera, Nader, Nancy, Suzuki, Shigeru, Liu, Wei, Jithesh, Puthen V., Kino, Tomoshige

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Accelerating next generation sequencing data analysis with system level optimizations von Kathiresan, Nagarajan, Temanni, Ramzi, Almabrazi, Hakeem, Syed, Najeeb, Jithesh, Puthen V., Al-Ali, Rashid

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Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling von Wang, Liyi, Steele, Islay, Kumar, Jothi Dinesh, Dimaline, Rod, Jithesh, Puthen V, Tiszlavicz, Laszlo, Reisz, Zita, Dockray, Graham J, Varro, Andrea

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Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor von Fadda, Abeer, Syed, Najeeb, Mackeh, Rafah, Papadopoulou, Anna, Suzuki, Shigeru, Jithesh, Puthen V., Kino, Tomoshige

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Targeting Treatment-Resistant Breast Cancer Stem Cells with FKBPL and Its Peptide Derivative, AD-01, via the CD44 Pathway von MCCLEMENTS, Lana, YAKKUNDI, Anita, MCINTOSH, Stuart, MCCARTHY, Helen O, O'NEILL, Eric, CLARKE, Robert B, ROBSON, Tracy, PAPASPYROPOULOS, Angelos, HARRISON, Hannah, ABLETT, Matthew P, JITHESH, Puthen V, MCKEEN, Hayley D, BENNETT, Rachel, DONLEY, Christopher, KISSENPFENNIG, Adrien

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The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer von Forsythe, Nicholas, Refaat, Alaa, Javadi, Arman, Khawaja, Hajrah, Weir, Jessica-Anne, Emam, Heba, Allen, Wendy L, Burkamp, Frank, Popovici, Vlad, Jithesh, Puthen V, Isella, Claudio, Labonte, Melissa J, Mills, Ian G, Johnston, Patrick G, Van Schaeybroeck, Sandra

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Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models von ALLEN, Wendy L, COYLE, Vicky M, JOHNSTON, Patrick G, JITHESH, Puthen V, PROUTSKI, Irina, STEVENSON, Leanne, FENNING, Cathy, LONGLEY, Daniel B, WILSON, Richard H, GORDON, Michael, LENZ, Heinz-Josef

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Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia[S] von Eagle, Gina L., Zhuang, Jianguo, Jenkins, Rosalind E., Till, Kathleen J., Jithesh, Puthen V., Lin, Ke, Johnson, Gillian G., Oates, Melanie, Park, Kevin, Kitteringham, Neil R., Pettitt, Andrew R.

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Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes von Razali, Rozaimi Mohamad, Rodriguez-Flores, Juan, Ghorbani, Mohammadmersad, Naeem, Haroon, Aamer, Waleed, Aliyev, Elbay, Jubran, Ali, Clark, Andrew G., Fakhro, Khalid A., Mokrab, Younes

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The colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information von Allen, Wendy L, Jithesh, Puthen V, Oliver, Gavin R, Proutski, Irina, Longley, Daniel B, Lenz, Heinz-Josef, Proutski, Vitali, Harkin, Paul, Johnston, Patrick G

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Analysis of 14,392 whole genomes reveals 3.5% of Qataris carry medically actionable variants von Elfatih, Amal, Saad, Chadi, Mifsud, Borbala, Mbarek, Hamdi

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Gene expression profiling in bladder cancer identifies potential therapeutic targets von Hussain, Syed A, Palmer, Daniel H, Syn, Wing-Kin, Sacco, Joseph J, Greensmith, Richard M.D, Elmetwali, Taha, Aachi, Vijay, Lloyd, Bryony H, Jithesh, Puthen V, Arrand, John, Barton, Darren, Ansari, Jawaher, Sibson, D. Ross, James, Nicholas D

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Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP von Elfatih, Amal, Da’as, Sahar I, Abdelrahman, Doua, Mbarek, Hamdi, Mohammed, Idris, Hasan, Waseem, Fakhro, Khalid A, Estivill, Xavier, Mifsud, Borbala

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Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity? von Mégarbané, André, Al-Ali, Rashid, Choucair, Nancy, Lek, Monko, Wang, Ena, Ladjimi, Moncef, Rose, Catherine M, Hobeika, Remy, Macary, Yvette, Temanni, Ramzi, Jithesh, Puthen V, Chouchane, Aouatef, Sastry, Konduru S, Thomas, Remy, Tomei, Sara, Liu, Wei, Marincola, Francesco M, MacArthur, Daniel, Chouchane, Lotfi

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