Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment von Laborda-Illanes, Aurora, Sanchez-Alcoholado, Lidia, Dominguez-Recio, Maria Emilia, Jimenez-Rodriguez, Begona, Lavado, Rocio, Comino-Mendez, Inaki, Alba, Emilio, Queipo-Ortuno, Maria Isabel

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Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis von Jiménez-Rodríguez, Begoña, Alba-Bernal, Alfonso, López-López, Esperanza, Quirós-Ortega, María Elena, Carbajosa, Guillermo, Garrido-Aranda, Alicia, Álvarez, Martina, Godoy-Ortiz, Ana, Queipo-Ortuño, María Isabel, Vicioso, Luis, Díaz-Córdoba, Gema, Roldán-Díaz, María Dunia, Velasco-Suelto, Jesús, Hernando, Cristina, Bermejo, Begoña, Julve-Parreño, Ana, Lluch, Ana, Pascual, Javier, Comino-Méndez, Iñaki, Alba, Emilio

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Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis von Rodriguez, Begona Jimenez, Córdoba, Gema Diaz, Aranda, Alicia Garrido, Álvarez, Martina, Vicioso, Luis, Pérez, Casilda Llácer, Hernando, Cristina, Bermejo, Begoña, Parreño, Ana Julve, Lluch, Ana, Ryder, Matthew B, Jones, Frederick S, Fredebohm, Johannes, Holtrup, Frank, Queipo-Ortuño, María Isabel, Alba, Emilio

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Safety and efficacy of ribociclib plus letrozole in patients with HR+, HER2– advanced breast cancer: Results from the Spanish sub-population of the phase 3b CompLEEment-1 trial von Salvador Bofill, Javier, Moreno Anton, Fernando, Rodriguez Sanchez, Cesar Augusto, Galve Calvo, Elena, Hernando Melia, Cristina, Ciruelos Gil, Eva Maria, Vidal, Maria, Jiménez-Rodriguez, Begoña, De la Cruz Merino, Luis, Martínez Jañez, Noelia, Villanueva Vazquez, Rafael, de Toro Salas, Ruben, Anton Torres, Antonio, Alvarez Lopez, Isabel Manuela, Gavila Gregori, Joaquin, Quiroga Garcia, Vanesa, Vicente Rubio, Elena, De la Haba-Rodriguez, Juan, Gonzalez-Santiago, Santiago, Diaz Fernandez, Nieves, Barnadas Molins, Agusti, Cantos Sanchez de Ibargüen, Blanca, Delgado Mingorance, Juan Ignacio, Bellet Ezquerra, Meritxell, de Casa, Sonia, Gimeno, Asuncion, Martin, Miguel

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Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients von Alba-Bernal, Alfonso, Godoy-Ortiz, Ana, Domínguez-Recio, María Emilia, López-López, Esperanza, Quirós-Ortega, María Elena, Sánchez-Martín, Victoria, Roldán-Díaz, María Dunia, Jiménez-Rodríguez, Begoña, Peralta-Linero, Jesús, Bellagarza-García, Estefanía, Troyano-Ramos, Laura, Garrido-Ruiz, Guadalupe, Hierro-Martín, M. Isabel, Vicioso, Luis, González-Ortiz, Álvaro, Linares-Valencia, Noelia, Velasco-Suelto, Jesús, Carbajosa, Guillermo, Garrido-Aranda, Alicia, Lavado-Valenzuela, Rocío, Álvarez, Martina, Pascual, Javier, Comino-Méndez, Iñaki, Alba, Emilio

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Targeted therapies in the treatment of germ cell tumors: The need for new approaches against “orphan” tumors von Sánchez-Muñoz, Alfonso, Jiménez-Rodríguez, Begoña, Navarro-Pérez, Víctor, Medina-Rodríguez, Laura, Llácer, Casilda, Vicioso, Luis, Machuca, Javier, Alba, Emilio

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Comparative study of droplet-digital PCR and absolute Q digital PCR for ctDNA detection in early-stage breast cancer patients von Sánchez-Martín, Victoria, López-López, Esperanza, Reguero-Paredes, Diego, Godoy-Ortiz, Ana, Domínguez-Recio, Maria Emilia, Jiménez-Rodríguez, Begoña, Alba-Bernal, Alfonso, Elena Quirós-Ortega, Maria, Roldán-Díaz, María Dunia, Velasco-Suelto, Jesús, Linares-Valencia, Noelia, Garrido-Aranda, Alicia, Lavado-Valenzuela, Rocío, Álvarez, Martina, Pascual, Javier, Alba, Emilio, Comino-Méndez, Iñaki

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Rechallenge with immune checkpoint inhibitors beyond severe toxicities, an utopia? von Medina Rodriguez, Laura, Jimenez-Rodriguez, Begona, Llácer, Casilda, Trigo Perez, Jose Manuel Manuel

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Challenges and achievements of liquid biopsy technologies employed in early breast cancer von Alba-Bernal, Alfonso, Lavado-Valenzuela, Rocío, Domínguez-Recio, María Emilia, Jiménez-Rodriguez, Begoña, Queipo-Ortuño, María Isabel, Alba, Emilio, Comino-Méndez, Iñaki

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Efficacy and safety of dostarlimab in patients (pts) with mismatch repair deficient (dMMR) solid tumors: Analysis of 2 cohorts in the GARNET study von Andre, Thierry, Berton, Dominique, Curigliano, Giuseppe, Jimenez-Rodriguez, Begona, Ellard, Susan, Gravina, Adriano, Miller, Rowan, Tinker, Anna, Jewell, Andrea, Pikiel, Joanna, Oaknin, Ana, Duan, Tao, Zildjian, Sybil, Zografos, Eleftherios, Veneris, Jennifer Taylor, Banerjee, Susana N.

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Antitumor activity and safety of dostarlimab monotherapy in patients with mismatch repair deficient non-endometrial solid tumors: A post-hoc subgroup analysis of patients with colo... von Andre, Thierry, De Braud, Filippo G., Jimenez-Rodriguez, Begona, Berton, Dominique, Curigliano, Giuseppe, Arkenau, Tobias, Antón Torres, Antonio, Paez, David, Ellard, Susan, Abdeddaim, Cyril, Castanon Alvarez, Eduardo, Aubin, Francine, Duan, Tao, Veneris, Jennifer Taylor, Zografos, Eleftherios, Starling, Naureen

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Plasma sequencing of ctDNA in early stage breast cancer as part of the screening process von Jimenez Rodriguez, Begona, Diaz Córdoba, Gema, Garrido Aranda, Alicia, Vicioso, Luis, Parrado, M Rosario Chica, de Luque, Vanessa, Lozano, Maria Jose, Moreno Ros, Mar, Bellagarza, Estefania, Hernando, Cristina, Bermejo, Begona, Lluch Hernandez, Ana, Álvarez, Martina, Jones, Frederick S., Nocon, Annette, Ryder, Matthew B., Fredebohm, Johannes, Mehnert, Daniel, Holtrup, Frank, Alba, Emilio

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B-PRECISE-01 Study: A phase Ib trial of MEN1611, a PI3K Inhibitor, combined with trastuzumab ± fulvestrant for the treatment of HER2-positive advanced or metastatic breast cancer von Piccart-Gebhart, Martine J., Aftimos, Philippe Georges, Duhoux, Francois P., Wildiers, Hans, Isambert, Nicolas, Campone, Mario, Tosi, Diego, Varga, Andrea I., Boni, Valentina, Doger, Bernard, Corbacho, Javier Garcia, Jimenez-Rodriguez, Begona, Ruiz Borrego, Manuel, Saura, Cristina, Arkenau, Hendrik-Tobias, Wardley, Andrew M., Troconiz, Inaki F, Binaschi, Monica, Simonelli, Cecilia, Pellacani, Andrea Ugo

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Different pCR rates according PAM50 defined subtypes in HER2 positive early breast cancer treated with neoadjuvant pertuzumab and trastuzumab von Diaz-Redondo, Tamara, Lavado-Valenzuela, Rocío, Jimenez Rodriguez, Begona, Pascual, Tomás, Montosa, Fernando Galvez, Falcon, Alejandro, Álamo de la Gala, Maria Carmen, Morales-Estevez, Cristina, Amerigo Góngora, Marta, Pascual, Javier, Ribelles, Nuria, González Guerrero, Macarena, Laborda Illanez, Aurora, Vicioso, Luis, Fernández, Aranzazu, Chic, Nuria, Jerez, Jose Manuel, Álvarez, Martina, Prat, Aleix, Alba, Emilio

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Abstract CT138: Translating preclinical observations to the clinic: Combination of the dual m-TORC1/2 inhibitor AZD2014 and paclitaxel in ovarian and lung cancer von Thavasu, Parames, Wong Te Fong, Anne-Christine LF, Jimenez Rodriguez, Begona, Basu, Bristi, Turner, Alison, Hall, Emma, Yap, Timothy A., Banerjee, Susana, Leach, Martin, de Bono, Johann S., Chung, Yuen-Li, Banerji, Udai

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A study of risk of infection with drugs targeting the PI3 kinase (PI3K), AKT, and mTOR pathway von Rafii, Saeed, Roda, Desamparados, Geuna, Elena, Jimenez Rodriguez, Begona, Rihawi, Karim, Capelan, Marta, Yap, Timothy Anthony, Kaye, Stanley B., Molife, L Rhoda, De Bono, Johann Sebastian, Banerji, Udai

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Long-term survivors in phase I clinical trials: Who are they and what predicts their survival? von Jimenez Rodriguez, Begona, Michie, Caroline Ogilvie, Lorente, David, Hassam, Hasina, Toloui, Helen Nicole, Lovosgaldeano, Jimena, Goswami, Debarati, De Bono, Johann Sebastian, Kaye, Stan B, Banerji, Udai, Molife, L Rhoda

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Prosigna (PAM50) to predict response to neoadjuvant chemotherapy (NAC) in HR+/HER2- early breast cancer (EBC) patients von Jimenez Rodriguez, Begona, Lavado Fernandez, Ana Isabel, Ribelles, Nuria, Sanchez-Rovira, Pedro, Vicioso, Luis, Alvarez, Martina, de Luque, Vanessa, Ramirez Tortosa, Cesar, Buckingham, Wesley, Schaper, Carl, Jeiranian, Arthur, Dowidar, Naeem, Ferree, Sean, Villar, Ester, Zarcos, Irene, Sanchez-Muñoz, Alfonso, Gonzalez-Hermoso, Carlos, Llacer Perez, Casilda, Prat, Aleix, Alba, Emilio

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Blinded independent validation of the PAM50-based Chemo-Endocrine Sensitivity Predictor (CESP) in hormone receptor (HR)-positive/HER2-negative (HR+/HER2-) breast cancer following n... von Prat, Aleix, Jimenez Rodriguez, Begona, Sánchez Rovira, Pedro, Alvarez, Martina, Vicioso, Luis, de Luque, Vanessa, Fernandez-Sousa, Cristina, Parrado, M Rosario Chica, Santonja, Angela, Ramirez Tortosa, Cesar, Lavado Fernandez, Ana Isabel, Perez Ruiz, Elisabeth, Gonzalez-Hermoso, Carlos, Buckingham, Wesley, Dowidar, Naeem, Ferree, Sean, Jeiranian, Arthur, Schaper, Carl, Ribelles, Nuria, Alba, Emilio

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Predicting the risk of VISIT emergency department (ED) in lung cancer patients using machine learning von Rodriguez-Brazzarola, Pablo, Ribelles, Nuria, Jerez, Jose Manuel, Trigo, Jose, Cobo, Manuel, Ramos Garcia, Inmaculada, Gutierrez Calderon, M Vanesa, Subirats, Jose Luis, Galeote Miguel, Ana María, Mesa, Hector, Galvez Carvajal, Laura, Franco, Leo, Jimenez Rodriguez, Begoña, Godoy, Ana, Ruíz, Sofía, Mesas, Andres, Iglesias Campos, Marcos, López, Irene, Rueda Dominguez, Antonio, Alba, Emilio

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