Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists von Evans, Karen A, Budzik, Brian W, Ross, Sean A, Wisnoski, David D, Jin, Jian, Rivero, Ralph A, Vimal, Mythily, Szewczyk, George R, Jayawickreme, Channa, Moncol, David L, Rimele, Thomas J, Armour, Susan L, Weaver, Susan P, Griffin, Robert J, Tadepalli, Sarva M, Jeune, Michael R, Shearer, Todd W, Chen, Zibin B, Chen, Lihong, Anderson, Donald L, Becherer, J. David, De Los Frailes, Maite, Colilla, Francisco Javier

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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors von Haffner, Curt D, Becherer, J. David, Boros, Eric E, Cadilla, Rodolfo, Carpenter, Tiffany, Cowan, David, Deaton, David N, Guo, Yu, Harrington, Wallace, Henke, Brad R, Jeune, Michael R, Kaldor, Istvan, Milliken, Naphtali, Petrov, Kim G, Preugschat, Frank, Schulte, Christie, Shearer, Barry G, Shearer, Todd, Smalley, Terrence L, Stewart, Eugene L, Stuart, J. Darren, Ulrich, John C

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Discovery of 4‑Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38 von Becherer, J. David, Boros, Eric E., Carpenter, Tiffany Y., Cowan, David J., Deaton, David N., Haffner, Curt D., Jeune, Michael R., Kaldor, Istvan W., Poole, J. Chuck, Preugschat, Frank, Rheault, Tara R., Schulte, Christie A., Shearer, Barry G., Shearer, Todd W., Shewchuk, Lisa M., Smalley, Terrence L., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.

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2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships von Deaton, David N., Haffner, Curt D., Henke, Brad R., Jeune, Michael R., Shearer, Barry G., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.

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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors von Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon

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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure von Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activat... von Shearer, Barry G, Wiethe, Robert W, Ashe, Adam, Billin, Andrew N, Way, James M, Stanley, Thomas B, Wagner, Craig D, Xu, Robert X, Leesnitzer, Lisa M, Merrihew, Raymond V, Shearer, Todd W, Jeune, Michael R, Ulrich, John C, Willson, Timothy M

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A knowledge-based, structural-aided discovery of a novel class of 2-phe-nylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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CGP 43371 paradoxically inhibits development of rabbit atherosclerotic lesions while inducing extra-arterial foam cell formation von Feldman, David L, Sawyer, Wilbur K, Jeune, Michael R, Mogelesky, Therese C, Von Linden-Reed, Jean, Forney Prescott, Margaret

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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethylbenzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activate... von SHEARER, Barry G, WIETHE, Robert W, SHEARER, Todd W, JEUNE, Michael R, ULRICH, John C, WILLSON, Timothy M, ASHE, Adam, BILLIN, Andrew N, WAY, James M, STANLEY, Thomas B, WAGNER, Craig D, XU, Robert X, LEESNITZER, Lisa M, MERRIHEW, Raymond V

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Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial von Jairath, Vipul, Dr, Kahan, Brennan C, MSc, Gray, Alasdair, FCEM, Doré, Caroline J, BSc, Mora, Ana, PhD, James, Martin W, MRCP, Stanley, Adrian J, FRCP, Everett, Simon M, MRCP, Bailey, Adam A, FRACP, Dallal, Helen, FRCP, Greenaway, John, FRCP, Le Jeune, Ivan, MRCP, Darwent, Melanie, FCEM, Church, Nicholas, MRCP, Reckless, Ian, MRCP, Hodge, Renate, MSc, Dyer, Claire, BSc, Meredith, Sarah, MFPHM, Llewelyn, Charlotte, PhD, Palmer, Kelvin R, FRCP, Logan, Richard F, Prof, Travis, Simon P, FRCP, Walsh, Timothy S, Prof, Murphy, Michael F, Prof

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Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis von Walsh, Michael, Merkel, Peter A, Peh, Chen-Au, Szpirt, Wladimir M, Puéchal, Xavier, Fujimoto, Shouichi, Hawley, Carmel M, Khalidi, Nader, Floßmann, Oliver, Wald, Ron, Girard, Louis P, Levin, Adeera, Gregorini, Gina, Harper, Lorraine, Clark, William F, Pagnoux, Christian, Specks, Ulrich, Smyth, Lucy, Tesar, Vladimir, Ito-Ihara, Toshiko, de Zoysa, Janak Rashme, Szczeklik, Wojciech, Flores-Suárez, Luis Felipe, Carette, Simon, Guillevin, Loïc, Pusey, Charles D, Casian, Alina L, Brezina, Biljana, Mazzetti, Andrea, McAlear, Carol A, Broadhurst, Elizabeth, Reidlinger, Donna, Mehta, Samir, Ives, Natalie, Jayne, David R.W

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Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries von Aranda, Zeus, Binde, Thierry, Tashman, Katherine, Tadikonda, Ananya, Mawindo, Bill, Maweu, Daniel, Boley, Emma Jean, Mphande, Isaac, Dumbuya, Isata, Montaño, Mariana, Clisbee, Mary, Mvula, Mc Geofrey, Ndayizigiye, Melino, Casella Jean-Baptiste, Meredith, Varney, Prince F, Anyango, Sarah, Grépin, Karen Ann, Law, Michael R, Mugunga, Jean Claude, Hedt-Gauthier, Bethany, Fulcher, Isabel R, Mugunga, Jean-Claude, I Faure, Peterson Abnis, Lambert, Wesler, Antoine, Jeune Marc, Boley, Emma Jean, Varney, Prince F, Msuya, Meba, Ndayizigiye, Melino, Aron, Moses, Connolly, Emilia, Aranda, Zeus, Bernal, Daniel, Cubaka, Vincent K, Karema, Nadine, Kateera, Fredrick, Binde, Thierry, Kachimanga, Chiyembekezo, Barnhart, Dale A, Fulcher, Isabel R, Hedt-Gauthier, Bethany, Murray, Megan, Grépin, Karen A, Law, Michael

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Childhood immunization during the COVID-19 pandemic: experiences in Haiti, Lesotho, Liberia and Malawi von Connolly, Emilia, Boley, Emma J, Fejfar, Donald Luke, Varney, Prince F, Aron, Moses B, Fulcher, Isabel R, Lambert, Wesler, Ndayizigiye, Melino, Law, Michael R, Mugunga, Jean-Claude, Hedt-Gauthier, Bethany

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The impact of COVID-19 and national pandemic responses on health service utilisation in seven low- and middle-income countries von Fejfar, Donald, Andom, Afom T., Msuya, Meba, Jeune, Marc Antoine, Lambert, Wesler, Varney, Prince F., Aron, Moses Banda, Connolly, Emilia, Juárez, Ameyalli, Aranda, Zeus, Niyigena, Anne, Cubaka, Vincent K., Boima, Foday, Reed, Vicky, Law, Michael R., Grépin, Karen A., Mugunga, Jean Claude, Hedt-Gauthier, Bethany, Fulcher, Isabel

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Thoracic aorta involvement in giant cell arteritis: a case-control analysis of morphological data at diagnosis von Rodrigues, F., Abad, S., Elourimi, G., Le Jeune, S., Mourad, J. -J., Warzocha, U., Larroche, C., Boissier, M. C., Bourgarit-Durand, A., Brillet, P. Y., Mekinian, A., Soussan, M., Dhote, R.

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Restrictive vs Liberal Blood Transfusion for Acute Upper Gastrointestinal Bleeding: Rationale and Protocol for a Cluster Randomized Feasibility Trial von Jairath, Vipul, Kahan, Brennan C, Gray, Alasdair, Doré, Caroline J, Mora, Ana, Dyer, Claire, Stokes, Elizabeth A, Llewelyn, Charlotte, Bailey, Adam A, Dallal, Helen, Everett, Simon M, James, Martin W, Stanley, Adrian J, Church, Nicholas, Darwent, Melanie, Greenaway, John, Le Jeune, Ivan, Reckless, Ian, Campbell, Helen E, Meredith, Sarah, Palmer, Kelvin R, Logan, Richard F.A, Travis, Simon P.L, Walsh, Timothy S, Murphy, Michael F

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Diaminoindanes as Microsomal Triglyceride Transfer Protein Inhibitors von Ksander, Gary M, deJesus, Reynalda, Yuan, Andrew, Fink, Cynthia, Moskal, Michael, Carlson, Eric, Kukkola, Paivi, Bilci, Natalie, Wallace, Eli, Neubert, Alan, Feldman, David, Mogelesky, Therese, Poirier, Kevin, Jeune, Michael, Steele, Ronald, Wasvery, Jong, Stephan, Zouhair, Cahill, Edna, Webb, Randy, Navarrete, Aida, Lee, Warren, Gibson, Joyce, Alexander, Natalya, Sharif, Haamid, Hospattankar, Ashok

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The impact of COVID-19 and national pandemic responses on health service utilisation in seven low- and middle-income countries von Fejfar, Donald, Andom, Afom T, Msuya, Meba, Jeune, Marc Antoine, Lambert, Wesler, Varney, Prince F, Aron, Moses Banda, Connolly, Emilia, Juárez, Ameyalli, Aranda, Zeus, Niyigena, Anne, Cubaka, Vincent K, Boima, Foday, Reed, Vicky, Law, Michael R, Grépin, Karen A, Mugunga, Jean Claude, Hedt-Gauthier, Bethany, Fulcher, Isabel

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