The Discovery and Development of Liraglutide and Semaglutide von Knudsen, Lotte Bjerre, Lau, Jesper

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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes von Graaf, Chris de, Donnelly, Dan, Wootten, Denise, Lau, Jesper, Sexton, Patrick M, Miller, Laurence J, Ahn, Jung-Mo, Liao, Jiayu, Fletcher, Madeleine M, Yang, Dehua, Brown, Alastair J H, Zhou, Caihong, Deng, Jiejie, Wang, Ming-Wei

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Structure of the human glucagon class B G-protein-coupled receptor von Siu, Fai Yiu, He, Min, de Graaf, Chris, Han, Gye Won, Yang, Dehua, Zhang, Zhiyun, Zhou, Caihong, Xu, Qingping, Wacker, Daniel, Joseph, Jeremiah S., Liu, Wei, Lau, Jesper, Cherezov, Vadim, Katritch, Vsevolod, Wang, Ming-Wei, Stevens, Raymond C.

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Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain von Runge, Steffen, Thøgersen, Henning, Madsen, Kjeld, Lau, Jesper, Rudolph, Rainer

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Structure of the full-length glucagon class B G-protein-coupled receptor von Zhang, Haonan, Qiao, Anna, Yang, Dehua, Yang, Linlin, Dai, Antao, de Graaf, Chris, Reedtz-Runge, Steffen, Dharmarajan, Venkatasubramanian, Zhang, Hui, Han, Gye Won, Grant, Thomas D., Sierra, Raymond G., Weierstall, Uwe, Nelson, Garrett, Liu, Wei, Wu, Yanhong, Ma, Limin, Cai, Xiaoqing, Lin, Guangyao, Wu, Xiaoai, Geng, Zhi, Dong, Yuhui, Song, Gaojie, Griffin, Patrick R., Lau, Jesper, Cherezov, Vadim, Yang, Huaiyu, Hanson, Michael A., Stevens, Raymond C., Zhao, Qiang, Jiang, Hualiang, Wang, Ming-Wei, Wu, Beili

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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls von Simonsen, Lotte, Lau, Jesper, Kruse, Thomas, Guo, Tingqing, McGuire, Jim, Jeppesen, Jacob Fuglsbjerg, Niss, Kristoffer, Sauerberg, Per, Raun, Kirsten, Dornonville de la Cour, Charlotta

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Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1 von Nilsson, Cecilia, Hansen, Thomas Kruse, Rosenquist, Christian, Hartmann, Bolette, Kodra, János T., Lau, Jesper F., Clausen, Trine Ryberg, Raun, Kirsten, Sams, Anette

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1332-P: Increased and Decreased Glucagon Receptor Signaling Respectively Enhances and Impairs Triglyceride Metabolism Acutely and Chronically von GALSGAARD, KATRINE D., CHRISTENSEN, EMILIE E., BOMHOLT, ANNA B., HUNT, JENNA, KRUSE, THOMAS, LAU, JESPER F., CHRISTOFFERSEN, CHRISTINA, HOLST, JENS J., WEWER ALBRECHTSEN, NICOLAI J.

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214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth von CHRISTENSEN, EMILIE E., GALSGAARD, KATRINE D., JOHANSEN, CHRISTIAN D., TRAMMELL, SAMUEL, BOMHOLT, ANNA B., HUNT, JENNA, KRUSE, THOMAS, LAU, JESPER F., GREVENGOED, TRISHA, HOLST, JENS J., WEWER ALBRECHTSEN, NICOLAI J.

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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells von Elmelund, Emilie, Galsgaard, Katrine D., Johansen, Christian D., Trammell, Samuel A.J., Bomholt, Anna B., Winther-Sørensen, Marie, Hunt, Jenna E., Sørensen, Charlotte M., Kruse, Thomas, Lau, Jesper F., Grevengoed, Trisha J., Holst, Jens J., Wewer Albrechtsen, Nicolai J.

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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice von Galsgaard, Katrine D, Elmelund, Emilie, Johansen, Christian D, Bomholt, Anna B, Kizilkaya, Hüsün S, Ceutz, Frederik, Hunt, Jenna E, Kissow, Hannelouise, Winther-Sørensen, Marie, Sørensen, Charlotte M, Kruse, Thomas, Lau, Jesper F, Rosenkilde, Mette M, Ørskov, Cathrine, Christoffersen, Christina, Holst, Jens J, Wewer Albrechtsen, Nicolai J

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Small-molecule agonists for the glucagon-like peptide 1 receptor von Knudsen, Lotte Bjerre, Kiel, Dan, Teng, Min, Behrens, Carsten, Bhumralkar, Dilip, Kodra, János T, Holst, Jens J, Jeppesen, Claus B, Johnson, Michael D, de Jong, Johannes Cornelis, Jorgensen, Anker Steen, Kercher, Tim, Kostrowicki, Jarek, Madsen, Peter, Olesen, Preben H, Petersen, Jacob S, Poulsen, Fritz, Sidelmann, Ulla G, Sturis, Jeppe, Truesdale, Larry, May, John, Lau, Jesper

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Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids von Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, Te Welscher, Yvonne M, Gonzalez, Rodrigo J, Softic, Samir, Pacheco, Michele, Mrsny, Randall J, Kahn, C Ronald, von Andrian, Ulrich H, Lau, Jesper, Pentelute, Bradley L, Lencer, Wayne I

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Editors’ Note: Europe Faces COVID-19 von Ventoruzzo, Marco, Conac, Pierre-Henri, Fleischer, Holger, Lau Hansen, Jesper, Kroeze, Maarten J., Merkt, Hanno, Recalde Castells, Andrés, Teichmann, Christoph, Wyckaert, Marieke

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Identification and in Vivo and in Vitro Characterization of Long Acting and Melanocortin 4 Receptor (MC4-R) Selective α-Melanocyte-Stimulating Hormone (α-MSH) Analogues von Conde-Frieboes, Kilian, Thøgersen, Henning, Lau, Jesper F, Sensfuss, Ulrich, Hansen, Thomas K, Christensen, Leif, Spetzler, Jane, Olsen, Helle B, Nilsson, Cecilia, Raun, Kirsten, Dahl, Kirsten, Hansen, Birgit S, Wulff, Birgitte S

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Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B von Andersen, Henrik Sune, Olsen, Ole H, Iversen, Lars F, Sørensen, Anette L. P, Mortensen, Steen B, Christensen, Michael S, Branner, Sven, Hansen, Thomas K, Lau, Jesper F, Jeppesen, Lone, Moran, Edmond J, Su, Jing, Bakir, Farid, Judge, Luke, Shahbaz, Manou, Collins, Tassie, Vo, Todd, Newman, Michael J, Ripka, William C, Møller, Niels Peter H

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Ureas with histamine H3-antagonist receptor activity : A new scaffold discovered by lead-hopping from cinnamic acid amides von LAU, Jesper F, JEPPESEN, Claus Bekker, RIMVALL, Karin, HOHLWEG, Rolf

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Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide von Lau, Jesper, Bloch, Paw, Schäffer, Lauge, Pettersson, Ingrid, Spetzler, Jane, Kofoed, Jacob, Madsen, Kjeld, Knudsen, Lotte Bjerre, McGuire, James, Steensgaard, Dorte Bjerre, Strauss, Holger Martin, Gram, Dorte X, Knudsen, Sanne Møller, Nielsen, Flemming Seier, Thygesen, Peter, Reedtz-Runge, Steffen, Kruse, Thomas

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Editors’ Note: Companies without Legal Capital and the Strange Case of Denmark von Hansen, Jesper Lau

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Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators von Song, Gaojie, Yang, Dehua, Wang, Yuxia, de Graaf, Chris, Zhou, Qingtong, Jiang, Shanshan, Liu, Kaiwen, Cai, Xiaoqing, Dai, Antao, Lin, Guangyao, Liu, Dongsheng, Wu, Fan, Wu, Yiran, Zhao, Suwen, Ye, Li, Han, Gye Won, Lau, Jesper, Wu, Beili, Hanson, Michael A., Liu, Zhi-Jie, Wang, Ming-Wei, Stevens, Raymond C.

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