Polypharmacology – Foe or Friend? von Peters, Jens-Uwe

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Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds von Peters, Jens-Uwe, Schnider, Patrick, Mattei, Patrizio, Kansy, Manfred

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Details Matter in Structure-based Drug Design von Kuhn, Bernd, Peters, Jens-Uwe, Rudolph, Markus G, Mohr, Peter, Stahl, Martin, Tosstorff, Andreas

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523... von Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar

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Safety screening in early drug discovery: An optimized assay panel von Bendels, Stefanie, Bissantz, Caterina, Fasching, Bernhard, Gerebtzoff, Grégori, Guba, Wolfgang, Kansy, Manfred, Migeon, Jacques, Mohr, Susanne, Peters, Jens-Uwe, Tillier, Fabien, Wyler, René, Lerner, Christian, Kramer, Christian, Richter, Hans, Roberts, Sonia

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Can we discover pharmacological promiscuity early in the drug discovery process? von Peters, Jens-Uwe, Hert, Jérôme, Bissantz, Caterina, Hillebrecht, Alexander, Gerebtzoff, Grégori, Bendels, Stefanie, Tillier, Fabien, Migeon, Jacques, Fischer, Holger, Guba, Wolfgang, Kansy, Manfred

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Synthesis of potential drug metabolites by a modified Udenfriend reaction von Slavik, Roger, Peters, Jens-Uwe, Giger, Rudolf, Bürkler, Markus, Bald, Eric

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Tyramine fragment binding to BACE-1 von Kuglstatter, Andreas, Stahl, Martin, Peters, Jens-Uwe, Huber, Walter, Stihle, Martine, Schlatter, Daniel, Benz, Jörg, Ruf, Armin, Roth, Doris, Enderle, Thilo, Hennig, Michael

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Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the... von Ceccarelli, Simona M., Schlotterbeck, Götz, Boissin, Patrick, Binder, Martin, Buettelmann, Bernd, Hanlon, Steven, Jaeschke, Georg, Kolczewski, Sabine, Kupfer, Ernst, Peters, Jens-Uwe, Porter, Richard H. P., Prinssen, Eric P., Rueher, Marianne, Ruf, Iris, Spooren, Will, Stämpfli, Andreas, Vieira, Eric

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Optimising brain penetration von PETERS, Jens-Uwe, LÜBBERS, Thomas, ALANINE, Alexander, KOLCZEWSKI, Sabine, BLASCO, Francesca, STEWARD, Lucinda

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Novel orally active, dibenzazepinone-based γ-secretase inhibitors von Peters, Jens-Uwe, Galley, Guido, Jacobsen, Helmut, Czech, Christian, David-Pierson, Pascale, Kitas, Eric A., Ozmen, Laurence

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Synthesis of [3H]fenobam, a radioligand for the mGlu5 receptor von Hartung, Thomas, Peters, Jens-Uwe, Wichmann, Jürgen, Hubschwerlen, Christian, Jaeschke, Georg

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1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors von Lübbers, Thomas, Böhringer, Markus, Gobbi, Luca, Hennig, Michael, Hunziker, Daniel, Kuhn, Bernd, Löffler, Bernd, Mattei, Patrizio, Narquizian, Robert, Peters, Jens-Uwe, Ruff, Yves, Wessel, Hans Peter, Wyss, Pierre

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A facile Horner–Wadsworth–Emmons route to 2-quinolones von Peters, Jens-Uwe, Capuano, Tony, Weber, Silja, Kritter, Stéphane, Sägesser, Matthias

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Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands von Peters, Jens-Uwe, Hoffmann, Torsten, Schnider, Patrick, Stadler, Heinz, Koblet, Andreas, Alker, André, Poli, Sonia Maria, Ballard, Theresa M., Spooren, Will, Steward, Lucinda, Sleight, Andrew J.

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Structure-activity relationship elucidation von PETERS, Jens-Uwe, LÜBBERS, Thomas, ALANINE, Alexander, KOLCZEWSKI, Sabine, BLASCO, Francesca, STEWARD, Lucinda

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Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents von Peters, Jens-Uwe, Weber, Silja, Kritter, Stéphane, Weiss, Peter, Wallier, Angelina, Boehringer, Markus, Hennig, Michael, Kuhn, Bernd, Loeffler, Bernd-Michael

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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity von Peters, Jens-Uwe, Kühne, Holger, Dehmlow, Henrietta, Grether, Uwe, Conte, Aurelia, Hainzl, Dominik, Hertel, Cornelia, Kratochwil, Nicole A., Otteneder, Michael, Narquizian, Robert, Panousis, Constantinos G., Ricklin, Fabienne, Röver, Stephan

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Lead Generation: Sowing the Seeds for Future Success von Bleicher, Konrad H., Nettekoven, Matthias, Peters, Jens-Uwe, Wyler, René

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Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure von Ceccarelli, Simona M., Jaeschke, Georg, Buettelmann, Bernd, Huwyler, Jörg, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Porter, Richard, Spooren, Will, Vieira, Eric

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