Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients von Schwank, Gerald, Koo, Bon-Kyoung, Sasselli, Valentina, Dekkers, Johanna F., Heo, Inha, Demircan, Turan, Sasaki, Nobuo, Boymans, Sander, Cuppen, Edwin, van der Ent, Cornelis K., Nieuwenhuis, Edward E.S., Beekman, Jeffrey M., Clevers, Hans

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High-resolution 3D imaging of fixed and cleared organoids von Dekkers, Johanna F., Alieva, Maria, Wellens, Lianne M., Ariese, Hendrikus C. R., Jamieson, Paul R., Vonk, Annelotte M., Amatngalim, Gimano D., Hu, Huili, Oost, Koen C., Snippert, Hugo J. G., Beekman, Jeffrey M., Wehrens, Ellen J., Visvader, Jane E., Clevers, Hans, Rios, Anne C.

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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank von Geurts, Maarten H., de Poel, Eyleen, Amatngalim, Gimano D., Oka, Rurika, Meijers, Fleur M., Kruisselbrink, Evelien, van Mourik, Peter, Berkers, Gitte, de Winter-de Groot, Karin M., Michel, Sabine, Muilwijk, Danya, Aalbers, Bente L., Mullenders, Jasper, Boj, Sylvia F., Suen, Sylvia W.F., Brunsveld, Jesse E., Janssens, Hettie M., Mall, Marcus A., Graeber, Simon Y., van Boxtel, Ruben, van der Ent, Cornelis K., Beekman, Jeffrey M., Clevers, Hans

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A functional CFTR assay using primary cystic fibrosis intestinal organoids von Dekkers, Johanna F, Wiegerinck, Caroline L, de Jonge, Hugo R, Bronsveld, Inez, Janssens, Hettie M, de Winter-de Groot, Karin M, Brandsma, Arianne M, de Jong, Nienke W M, Bijvelds, Marcel J C, Scholte, Bob J, Nieuwenhuis, Edward E S, van den Brink, Stieneke, Clevers, Hans, van der Ent, Cornelis K, Middendorp, Sabine, Beekman, Jeffrey M

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Readthrough compounds for nonsense mutations: bridging the translational gap von Spelier, Sacha, van Doorn, Eveline P.M., van der Ent, Cornelis K., Beekman, Jeffrey M., Koppens, Martijn A.J.

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Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids von Chen, Kevin G., Zhong, Pingyu, Zheng, Wei, Beekman, Jeffrey M.

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Modeling rotavirus infection and antiviral therapy using primary intestinal organoids von Yin, Yuebang, Bijvelds, Marcel, Dang, Wen, Xu, Lei, van der Eijk, Annemiek A., Knipping, Karen, Tuysuz, Nesrin, Dekkers, Johanna F., Wang, Yijin, de Jonge, Jeroen, Sprengers, Dave, van der Laan, Luc J.W., Beekman, Jeffrey M., ten Berge, Derk, Metselaar, Herold J., de Jonge, Hugo, Koopmans, Marion P.G., Peppelenbosch, Maikel P., Pan, Qiuwei

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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization von van Loosdregt, Jorg, Vercoulen, Yvonne, Guichelaar, Teun, Gent, Yoony Y.J., Beekman, Jeffrey M., van Beekum, Olivier, Brenkman, Arjan B., Hijnen, Dirk-Jan, Mutis, Tuna, Kalkhoven, Eric, Prakken, Berent J., Coffer, Paul J.

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Modulation of the maladaptive stress response to manage diseases of protein folding von Roth, Daniela Martino, Hutt, Darren M, Tong, Jiansong, Bouchecareilh, Marion, Wang, Ning, Seeley, Theo, Dekkers, Johanna F, Beekman, Jeffrey M, Garza, Dan, Drew, Lawrence, Masliah, Eliezer, Morimoto, Richard I, Balch, William E

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The ins and outs of syntenin, a multifunctional intracellular adaptor protein von Beekman, Jeffrey M, Coffer, Paul J

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An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking von Schneeberger, Kerstin, Vogel, Georg F., Teunissen, Hans, van Ommen, Domenique D., Begthel, Harry, Bouazzaoui, Layla El, van Vugt, Anke H. M., Beekman, Jeffrey M., Klumperman, Judith, Müller, Thomas, Janecke, Andreas, Gerner, Patrick, Huber, Lukas A., Hess, Michael W., Clevers, Hans, van Es, Johan H., Nieuwenhuis, Edward E. S., Middendorp, Sabine

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Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids von Vonk, Annelotte M., van Mourik, Peter, Ramalho, Anabela S., Silva, Iris A.L., Statia, Marvin, Kruisselbrink, Evelien, Suen, Sylvia W.F., Dekkers, Johanna F., Vleggaar, Frank P., Houwen, Roderick H.J., Mullenders, Jasper, Boj, Sylvia F., Vries, Robert, Amaral, Margarida D., de Boeck, Kris, van der Ent, Cornelis K., Beekman, Jeffrey M.

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Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis von Rodenburg, Lisa W., Metzemaekers, Mieke, van der Windt, Isabelle S., Smits, Shannon M. A., den Hertog-Oosterhoff, Loes A., Kruisselbrink, Evelien, Brunsveld, Jesse E., Michel, Sabine, de Winter-de Groot, Karin M., van der Ent, Cornelis K., Stadhouders, Ralph, Beekman, Jeffrey M., Amatngalim, Gimano D.

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Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19 von Rümke, Lidewij W, Smit, Wouter L, Bossink, Ailko, Limonard, Gijs J M, Muilwijk, Danya, Haas, Lenneke E M, Reusken, Chantal, van der Wal, Sanne, Thio, Bing J, van Os, Yvonne M G, Gremmels, Hendrik, Beekman, Jeffrey M, Nijhuis, Monique, Wensing, Annemarie M J, Heron, Michiel, Thijsen, Steven F T

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Individualized medicine using intestinal responses to CFTR potentiators and correctors von Beekman, Jeffrey M.

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Effects of Aspergillus fumigatus colonization on lung function in cystic fibrosis von Speirs, Jennifer J, van der Ent, Cornelis K, Beekman, Jeffrey M

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High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing von Spelier, Sacha, de Poel, Eyleen, Ithakisiou, Georgia N, Suen, Sylvia W F, Hagemeijer, Marne C, Muilwijk, Danya, Vonk, Annelotte M, Brunsveld, Jesse E, Kruisselbrink, Evelien, van der Ent, Cornelis K, Beekman, Jeffrey M

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OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion von Lefferts, Juliet W., Kroes, Suzanne, Smith, Matthew B., Niemöller, Paul J., Nieuwenhuijze, Natascha D. A., Sonneveld van Kooten, Heleen N., van der Ent, Cornelis K., Beekman, Jeffrey M., van Beuningen, Sam F. B.

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Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay von Rodenburg, Lisa W., van der Windt, Isabelle S., Dreyer, Henriette H.M., Smits, Shannon M.A., den Hertog - Oosterhoff, Loes A., Aarts, Ellen M., Beekman, Jeffrey M., Amatngalim, Gimano D.

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STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass von de Jong, Petrus R, Schadenberg, Alvin W L, van den Broek, Theo, Beekman, Jeffrey M, van Wijk, Femke, Coffer, Paul J, Prakken, Berent J, Jansen, Nicolaas J G

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